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School of Public Health
Department: Biomedical Sciences
Gene regulation; infectious disease; bacterial pathogenisis
Campus phone: (518) 486-4253
Campus email: email@example.com
Kathleen McDonough is a professor of biomedical sciences at the School of Public Health and deputy director of the Division of Infectious Disease at the Wadsworth Center.
The focus of Professor McDonough's laboratory is gene regulation in the context of bacterial pathogenesis, or the means by which bacteria cause disease. The team is primarily interested in two well known pathogens: Mycobacterium tuberculosis, the bacterium that causes TB, and Yersinia pestis, the etiologic agent of bubonic and pneumonic plague.
The lab uses a variety of techniques in their studies with both pathogens, ranging from molecular genetics and biochemistry to bioinformatics, proteomics and fluorescence microscopy.
The long term objective of the laboratory’s Mtb work is to gain a better understanding, at the molecular and cellular levels, of how this highly pathogenic bacterium establishes infection so that effective strategies can be developed to prevent tuberculosis infection and/or disease.