John Douglas Cleary

Percutaneous Connector for Large Animal, in vivo Studies, with Open-Source Designs

Cleary JD, Kekesi O, Suaning GJ. Annu Int Conf IEEE Eng Med Biol Soc. 2024 Jul;2024:1-5. doi: 10.1109/EMBC53108.2024.10782517. PMID: 40039942.

Dysregulation of alternative splicing is a transcriptomic feature of patient-derived fibroblasts from CAG repeat expansion spinocerebellar ataxias.

Aliyeva A, Lennon CD, Cleary JD, Shorrock HK, Berglund JA.  Hum Mol Genet. 2025 Feb 1;34(3):239-250. doi: 10.1093/hmg/ddae174. PMID: 39589088; PMCID: PMC11792238.

Alternative splicing dysregulation across tissue and therapeutic approaches in a mouse model of myotonic dystrophy type 1.

Hicks SM, Frias JA, Mishra SK, Scotti M, Muscato DR, Valero MC, Adams LM, Cleary JD, Nakamori M, Wang E, Berglund JA.  Mol Ther Nucleic Acids. 2024 Sep 13;35(4):102338. doi: 10.1016/j.omtn.2024.102338. PMID: 39391766; PMCID: PMC11465180.

CAG repeat-selective compounds reduce abundance of expanded CAG RNAs in patient cell and murine models of SCAs. 

Shorrock HK, Aliyeva A, Frias JA, DeMeo VA, Lennon CD, DeMeo CC, Mascorro AK, Shaughnessy S, Mazdiyasni H, Cleary JD, Reddy K, Vangaveti S, Shin DS, Berglund JA. bioRxiv [Preprint]. 2024 Aug 17:2024.08.17.608349. doi: 10.1101/2024.08.17.608349. PMID: 39211226; PMCID: PMC11360937.

Expression levels of core spliceosomal proteins modulate the MBNL-mediated spliceopathy in DM1.

Louis JM, Frias JA, Schroader JH, Jones LA, Davey EE, Lennon CD, Chacko J, Cleary JD, Berglund JA, Reddy K.  Hum Mol Genet. 2024 Nov 5;33(21):1873-1886. doi: 10.1093/hmg/ddae125. PMID: 39180495; PMCID: PMC11540926.

Counting the Cost of Daptomycin Versus Vancomycin in Hospitalized Patients: A Cost Minimization Analysis.

Wagner JL, Jones BM, Stover KR, Cleary JD, Bland CM, Schipper KE, Chastain DB, Barber KE.  Open Forum Infect Dis. 2024 Apr 18;11(5):ofae217. doi: 10.1093/ofid/ofae217. PMID: 38737432; PMCID: PMC11083637.

Widespread alternative splicing dysregulation occurs presymptomatically in CAG expansion spinocerebellar ataxias.

Shorrock HK, Lennon CD, Aliyeva A, Davey EE, DeMeo CC, Pritchard CE, Planco L, Velez JM, Mascorro-Huamancaja A, Shin DS, Cleary JD, Berglund JA. Brain. 2024 Feb 1;147(2):486-504. doi: 10.1093/brain/awad329. PMID: 37776516; PMCID: PMC10834251.

Individual transcriptomic response to strength training for patients with myotonic dystrophy type 1.

Davey EE, Légaré C, Planco L, Shaughnessy S, Lennon CD, Roussel MP, Shorrock HK, Hung M, Cleary JD, Duchesne E, Berglund JA.  JCI Insight. 2023 Jul 24;8(14):e163856. doi: 10.1172/jci.insight.163856. PMID: 37318869; PMCID: PMC10443797.

Alternative Splicing Outcomes Across an RNA-Binding Protein Concentration Gradient.

Ellis JA, Hale MA, Cleary JD, Wang ET, Andrew Berglund J.  J Mol Biol. 2023 Aug 1;435(15):168156. doi: 10.1016/j.jmb.2023.168156. Epub 2023 May 23. PMID: 37230319.

Quercetin selectively reduces expanded repeat RNA levels in models of myotonic dystrophy.

Mishra SK, Hicks SM, Frias JA, Vangaveti S, Nakamori M, Cleary JD, Reddy K, Berglund JA.  bioRxiv [Preprint]. 2023 Feb 2:2023.02.02.526846. doi: 10.1101/2023.02.02.526846. PMID: 36778282; PMCID: PMC9915578.