Roxana Moslehi
Postdoctoral Fellowship [Genetic Epidemiology and Biostatistics], Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), NIH
Ph.D. [Medical Genetics], University of British Columbia
M.Sc. [Medical Genetics], University of British Columbia
B.Sc.(Honors) [Cell & Developmental Biology], University of British Columbia
Research Interests
The overall objectives of my research studies are to identify genetic and environmental determinants of complex disorders and to quantify their effects. I have expertise in designing family-based and population-based genetic epidemiologic investigations and in statistical analysis of genetic and epidemiologic data. As part of my studies, I have also conducted genetic counseling for hereditary cancer susceptibility. The methodologies currently employed in my laboratory include family studies, case-control studies, analysis of genome-wide association studies (GWAS), candidate-gene and whole-genome linkage analyses, and gene expression (gene chip) array and transcriptome analyses. Various malignant and pre-malignant conditions have been the focus of my research. I have been studying cancer risks associated with mutations in the DNA repair genes for a number of years. Based on recent clinical observations, I also initiated several studies to gain insight into the biologic mechanisms which underlie the association between DNA repair and transcription gene abnormalities in the fetus and increased risk of gestational complications.
More recently, through an NIH R21 grant (PI: R. Moslehi), I initiated a molecular epidemiologic investigation of Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) to explore genetic and immunologic links between ME/CFS, autoimmune disorders, and cancer. I have also obtained two recent intramural NIH grants to conduct whole-genome sequencing and RNA-Seq analyses to identify genes involved in the etiology of ME/CFS.
Courses taught
- “Cancer Epidemiology” (EPI 604)
- “Genetic Epidemiology” (EPI 624)
- “Masters Seminars in Epidemiology” (EPI 602)
- “Principles and Methods of Epidemiology II” (EPI 502)
- "Principles and Methods of Epidemiology I" (EPI 501)
- "Basic Principles and Methods of Epidemiology" (EPI 500)
- “Molecular Epidemiology” (EPI 512)
- "From Cholera to Cancer: History, Challenges, and Achievements in Public Health" (SPH 202)
- "Infectious Disease Epidemiology" (EPI 605)