Michael Zuker

  • MATH - RPI

    Dr Zucker's research centers on the development and implementation of bioinformatics algorithms to predict the folding and hybridization of RNA. Using "nearest neighbor" energy rules obtained from thermodynamic experiments by Turner and coworkers, Dr. Zucker created the highly successful "MFold" algorithm and associated web server which is among the most successful (and highly cited) RNA bioinformatics tools in use today across all sectors of biomedical research. Dr. Zucker's research currently centers on developing the UNAFOLD web server, which is hosted at the RNA Institute, UAlbany. UNAFOLD simulates folding, hybridization, and melting pathways for RNA or DNA strands, combining free energy minimization, partition function calculations and stochastic sampling methods.