We study the molecular basis of persistence of one of the deadliest bacterial pathogens, Mycobacterium tuberculosis (Mtb), which kills over a million people every year. Mtb is the causative agent of human tuberculosis (TB), which has inflicted humans since the prehistoric era. The only possible treatment of TB is a multi-drug regimen administered over 6-9 months. Towards developing a shorter treatment regimen, the overarching goal of our research program is to decipher the molecular mechanisms of persistence of Mtb during an antibiotic exposure.
Please visit the Ojha Laboratory for details.
Li Y, Corro JH, Palmer CD, Ojha AK.
Progression from remodeling to hibernation of ribosomes in zinc-starved mycobacteria. Proc Natl Acad Sci U S A. (2020) 10.1073/pnas.2013409117
Richards JP, Cai W, Zill NA, Zhang W, Ojha AK. Adaptation of Mycobacterium tuberculosis to Biofilm Growth Is Genetically Linked to Drug Tolerance. Antimicrob Agents Chemother. (2019) 63 (11): e01213-19.