Bijan K. Dey
Senior Principal Investigator of the RNA Institute; Adjunct Associate Professor of Biological Sciences
The RNA Institute
Secondary Contact
Lab
Life Sciences 2020
About
My laboratory studies the function of non-coding RNAs, epigenetics, and epitranscriptomics in skeletal muscle stem cell biology, cardiac muscle biology, muscle regeneration, and muscle degenerative diseases, including Duchenne Muscular Dystrophy (DMD) and DMD-associated cardiomyopathy.
DMD is a devastating X-linked childhood muscle degenerative disease. There is no effective treatment available currently that can either cure or stop the progression of DMD. The development of successful therapy for DMD has been hindered due to the lack of a comprehensive understanding of the critical myogenic processes and DMD pathophysiology at the cellular and molecular level.
Our goal is to understand the fundamental molecular mechanism of muscle development and devise new therapeutic and diagnostic platforms for DMD and related muscle degenerative diseases.
Research
Research Interests
- Stem Cell Biology
- Muscle Development and Regeneration
- Duchenne Muscular Dystrophy
- Non-coding RNAs (microRNAs and long non-coding RNAs)
- Epigenetics and Epitranscriptomics
Publications
- Dey P, Soyer MA, Dey BK (2022) MicroRNA-24-3p promotes skeletal muscle differentiation and regeneration by regulating HMGA1. Cellular and Molecular Life Sciences. Vol: 79(3):170. doi: 10.1007/s00018-022-04168-7. PMID: 35238991.
- Ralbovsky NM, Dey P, Galfano A, Dey BK, Lednev IK (2022). A Novel Method for Detecting Duchenne Muscular Dystrophy in Blood Serum of mdx Mice. Genes. Vol: 13(8):1342. doi: 10.3390/genes13081342. PMID: 36011258.
- Zhou L, Hayden A, Chandrasekaran AR, Vilcapoma J, Cavaliere C, Dey P, Mao S, Sheng J, Dey BK, Rangan P, Halvorsen K (2021). Sequence-selective purification of biological RNAs using DNA nanoswitches. Cell Rep Methods. Vol: 1(8):100126. doi: 10.1016/j.crmeth.2021.100126. PMID: 35072148.
- Ralbovsky NM, Dey P, Dey BK, Lednev IK (2021). Determining the stages of cellular differentiation using deep ultraviolet resonance Raman spectroscopy. Talanta. Vol: 227:122164. doi: 10.1016/j.talanta.2021.122164. PMID: 33714467.
- Ray HC, Corliss BA, Bruce AC, Kesting S, Dey P, Mansour J, Seaman SA, Smolko CM, Mathews C, Dey BK, Owens GK, Peirce SM, Yates PA (2020). Myh11+ microvascular mural cells and derived mesenchymal stem cells promote retinal fibrosis. Sci Rep. doi: 10.1038/s41598-020-72875-x. PubMed PMID: 32978500; PubMed Central PMCID: PMC7519078.
- Ralbovsky NM, Dey P, Galfano A, Dey BK, Lednev IK (2020). Diagnosis of a model of Duchenne muscular dystrophy in blood serum of mdx mice using Raman hyperspectroscopy. Sci Rep. Vol 10(1):11734. doi: 10.1038/s41598-020-68598-8.
- Chandrasekaran AR, Vilcapoma J, Dey P, Wong-Deyrup SW, Dey BK, Halvorsen K (2020). Exceptional Nuclease Resistance of Paranemic Crossover (PX) DNA and Crossover-Dependent Biostability of DNA Motifs. J Am Chem Soc. Vol 142(14):6814-6821. doi: 10.1021/jacs.0c02211.
- Chandrasekaran AR, Dey BK, Halvorsen K (2020). How to Perform miRacles: A Step-by-Step microRNA Detection Protocol Using DNA Nanoswitches. Current Protocols in Molecular Biology. Vol130(1):e114. doi: 10.1002/cpmb.114.
- Chandrasekaran AR, Punoose JA, Zhou L, Dey P, Dey BK, Halvorsen K (2019). DNA nanotechnology approaches for microRNA detection and diagnosis. Nucleic Acid Research. doi: 10.1093/nar/gkz580.
- Chandrasekaran AR, MacIsaac M, Dey P, Levchenko O, Zhou L, Andres M, Dey BK, Halvorsen K (2019). Cellular microRNA detection with miRacles: microRNA activated conditional looping of engineered switches. Science Advances. Vol 5(3) doi: 10.1126/sciadv.aau9443.
- Ralbovskya NM, Egorov V, Moskovets E, Dey, P, Dey BK, Lednev IK (2019). Deep-Ultraviolet Raman Spectroscopy for Cancer Diagnostics: A Feasibility Study with Cell Lines and Tissues. Cancer Studies and Molecular Medicine. Vol 5(1): 1-10. doi: 10.17140/CSMMOJ-5-126.
- Mueller AC, Wegrzynska M, Dey BK, Layer R, Gagan J, Dutta A (2015). MUNC, a long noncoding RNA that facilitates the function of MyoD in skeletal myogenesis. Molecular and Cellular Biology, Vol 35:498-513. doi: 10.1128/MCB.01079-14.
- Cronk SM et al. (2015). Adipose-derived stem cells from diabetic mice show impaired vascular stabilization in a murine model of diabetic retinopathy. Stem Cells Translational Medicine, Vol 4:459-67. doi: 10.5966/sctm.2014-0108
- Ray H, J Park, Mansour J, Seaman S, Dey BK, Peirce S, Yates PA (2015). A Lineage Tracing System to Fate Map Perivascular-Derived Adipose Stem Cells in Retinal Vasculopathy Mouse Models. Investigative Ophthalmology & Visual Science. Vol 56(7):1831-1831.
- Dey BK, Mueller A, and Dutta A (2014). Long non-coding RNAs as emerging regulators of differentiation, development, and disease. Transcription, Vol 5(4): e944014. doi: 10.4161/21541272.2014.944014.
- Dey BK, Pfeifer K, and Dutta A (2014). The H19 long non-coding RNA gives rise to microRNAs miR-675-3p and -5p to promote skeletal muscle differentiation and regeneration. Genes & Development, Vol 28: 491-501.doi: 10.1101/gad.234419.113
- Floyd DH, Zhang Y, Dey BK, Kefas B, Glass R, Dutta A, Abounader R, and Purow BW (2014). Novel anti-apoptotic microRNAs 582-5p and 363 promote human glioblastoma stem cell survival via direct inhibition of Caspase 3, Caspase 9, and Bim. PLoS One, Vol 9: e96239.
- Zhang Y, Floyd DH, Mueller A, Dey BK, Yang Y, Lee DH, HAchmann J, Finderle S, Park DM, Christense J, Schiff D, Purow BW, Dutta A, and Abounader R (2014). Multiple receptor tyrosine kinases converge on microRNA-134 to control KRAS, STAT5B, and glioblastoma. Cell Death & Differentiation, Vol 21:720-734.
- Zhang Y, Floyd DH, Mueller A, Dey BK, Yang Y, Lee DH, HAchmann J, Finderle S, Park DM, Christense J, Schiff D, Purow BW, Dutta A, and Abounader R (2014). Identification and characterization of microRNA-134 as a novel receptor tyrosine kinase-regulated tumor suppressive hub in glioblastoma. Cancer Research, 74:1909.
- Dey BK, Mueller A, and Dutta A (2012). Non-micro-short RNAs: the new kids on the block. Molecular Biology of the Cell, Vol 23: 4664–4667.
- Gagan J, Dey BK, Layer, R, Yan, Z, and Dutta A (2012). Notch3 and Mef2c are mutually antagonistic via Mkp1 and miR-1/206 in differentiating myoblast. Journal of Biological Chemistry, Vol 287:40360–370.
- Dey BK, Gagan J, Yan Z, and Dutta A (2012). MiR-26a promotes skeletal muscle differentiation and regeneration in mice. Genes & Development, Vol 26: 2180–2191.
- Gagan J, Dey BK, and Dutta A (2012). MicroRNAs regulate and provide robustness to the myogenic transcriptional network. Current Opinion in Pharmacology, Vol 12:1–6.
- Gagan J, Dey BK, Layer R, Yan Z, and Dutta A (2011). MicroRNA-378 targets the myogenic repressor MyoR during myoblast differentiation. Journal of Biological Chemistry, Vol 286:19431–19438.
- Dey BK, Gagan J, and Dutta A (2011). MiR-206 and -486 induce myoblast differentiation by downregulating Pax7. Molecular and Cellular Biology, Vol 31: 203–214.
- Sarkar S, Dey BK, and Dutta A (2010). MiR-322/424 and -503 are induced during muscle differentiation and promote cell cycle quiescence and differentiation by down-regulation of Cdc25A. Molecular Biology of the Cell, Vol 21:2138–2149
- Dey BK, Zhao X, Popoola M, and Campos AR (2009). Mutual regulation of the Drosophila disconnected (disco) and Distal-less (Dll) genes is implicated in the proximal-distal patterning of antenna and leg. Cell Tissue Research, Vol 338: 227–240.
- Dey BK, Stalker L, Schnerch A, Bhatia M, Taylor-Papidimtriou J, and Wynder C (2008). The histone demethylase KDM5b/JARID1b plays a role in cell fate decisions by blocking terminal differentiation. Molecular and Cellular Biology, Vol 28:5312–5327.