Ben Boivin
Postdoctoral Fellow, Cancer Center – Signal Transduction Program, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 2011
PhD, Biochemistry, University of Montreal, Montreal Heart Institute, Montreal, Canada, 2006
BSc, Biochemistry, University of Montreal, Montreal, Canada, 1998
About
Before joining UAlbany's faculty, Dr. Boivin served as an assistant professor for the University of Montreal's Department of Medicine and Montreal Heart Institute, as well as an adjunct assistant professor for McGill University's Department of Pharmacology and Therapeutics.
Research
Research Interests
- Protein Tyrosine Phosphatases
- Post-Translational Modifications and Signal Transduction
- Cardiac biochemistry and biology
- Cancer biochemistry and biology
- Cardiac toxicology
- Nanobiotechnology
Publications
Yang, M., Haase, A.D., Huang, F.K., Coulis, G., Rivera, K.D., Dickinson, B.D., Chang, C.J., Pappin, D.J., Neubert, T.A., Hannon, G.J., Boivin, B.*, and Tonks, N.K*. (2014) Dephosphorylation of Tyrosine 393 in Argonaute 2 by Protein Tyrosine Phosphatase 1B Regulates Gene Silencing in Oncogenic RAS-Induced Senescence.Mol. Cell. 55, 782-790.
Note: Boivin and Tonks are co-senior authors and co-corresponding authors.
Boivin, B. and Tonks, N.K. (2015) PTP1B: deciphering ROS signal for gene silencing. Mol. Cell. Oncol. 2 (2): e975633-1.
Dagnell, M., Frijhoff, J., Pader, I., Paten, A., Boivin, B., Mandal, P.J., Tonks, N.K., Hellberg, C., Conrad, M., Arner, E.S.J., Östman, A. (2013) Thioredoxin-mediated selective activation of oxidized PTP1B modulates PDGF-receptor tyrosine kinase signaling. Proc. Natl Acad. Sci. U.S.A. 110, 13398-13403.
Boivin, B., Chaudary, F., Dickinson, B., Haque, A., Pero, S., Chang, C., Tonks, N.K. (2013) Receptor Protein Tyrosine Phosphatase Regulates Focal Adhesion Kinase Phosphorylation and ErbB2 Oncoprotein-Mediated Mammary Epithelial Cell Motility. J. Biol. Chem. 288, 36926-36935.
Boivin, B., Yang, M., Tonks, N.K. (2010) Targeting the Reversibly Oxidized Protein Tyrosine Phosphatase Superfamily. Sci. Signal. 3, pl2.
Loh, K., Deng, H., Fukushima, A., Cai, X., Boivin, B., Galic, S., Bruce, C., Shields, B.J., Skiba, B., Ooms, L.M., Stepto, N., Wu, B., Mitchell, C.A., Tonks, N.K., Watt, M.J., Febbraio, M.A., Crack, P.J., Andrikopoulos, S., Tiganis, T. (2009) Reactive oxygen species enhance insulin sensitivity. Cell Metab. 10, 260-272.
Juarez, J.C., Manuia, M., Burnett, M.E., Betancourt, O., Boivin, B., Shaw, D.E., Tonks, N.K., Mazar, A.P., Doñate, F. (2008) Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling. Proc. Natl Acad. Sci. U.S.A. 105, 7147-7152
Boivin, B., Zhang S, Arbiser JL, Zhang ZY, Tonks NK. (2008) A modified cysteinyl labeling assay reveals reversible oxidation of protein tyrosine phosphatases in angiomyolipoma cells. Proc. Natl Acad. Sci. U.S.A. 105, 9959-9964.
Boivin B, Chevalier D, Villeneuve LR, Rousseau E, Allen BG. (2003) Functional endothelin receptors are present on nuclei in cardiac myocytes. J. Biol. Chem. 278, 29153-29163.
Boivin, B, Lavoie C, Vaniotis G, Baragli A, Villeneuve LR, Ethier N, Trieu P, Allen BG, Hébert TE. (2006) Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular myocytes. Cardiovasc. Res. 71, 69-78.
Boivin, B., Vaniotis, G., Allen, B.G., and Hébert, T. (2008) G protein-coupled receptors in and on the cell nucleus: a new signalling paradigm? J. Rec Sig. Trans. 28, 15-28
Additional Information
Awards & Honors
- Jacques-de-Champlain Excellence Award, Heart and Stroke Foundation
- Research Scholar Award (Junior 1), Fonds de Recherche du Quebec – Sante
- Heart and Stroke Foundation of Canada Fellowship
- Fonds de Recherche en Sante du Quebec Fellowship
- Cold Spring Harbor Association Fellowship