Ben Boivin
Secondary Contact
Postdoctoral Fellow, Cancer Center – Signal Transduction Program, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 2011
PhD, Biochemistry, University of Montreal, Montreal Heart Institute, Montreal, Canada, 2006
BSc, Biochemistry, University of Montreal, Montreal, Canada, 1998
About
After completing his PhD by working on nuclear G-protein coupled receptors in the heart, Boivin joined the Cold Spring Harbor Laboratory for postdoctoral training on the redox-regulation of protein tyrosine phosphatases (PTP).
The current focus of his lab is to understand how cells respond to their environment by sending intracellular redox signals that turn off PTPs and regulate phosphorylation events. Researchers in his lab concentrate their efforts on understanding how PTPs can be reactivated in vitro and in vivo and how they can reestablish physiological signaling.
Boivin’s research has been acknowledged by fellowships, scholarships and awards and his lab is funded by the National Institutes of Health.
Research
Research Interests
- Protein Tyrosine Phosphatases
- Post-Translational Modifications and Signal Transduction
- Cardiac biochemistry and biology
- Cancer biochemistry and biology
- Cardiac toxicology
- Nanobiotechnology
Publications
Yang, M., Haase, A.D., Huang, F.K., Coulis, G., Rivera, K.D., Dickinson, B.D., Chang, C.J., Pappin, D.J., Neubert, T.A., Hannon, G.J., Boivin, B.*, and Tonks, N.K*. (2014) Dephosphorylation of Tyrosine 393 in Argonaute 2 by Protein Tyrosine Phosphatase 1B Regulates Gene Silencing in Oncogenic RAS-Induced Senescence.Mol. Cell. 55, 782-790.
Note: Boivin and Tonks are co-senior authors and co-corresponding authors.
Boivin, B. and Tonks, N.K. (2015) PTP1B: deciphering ROS signal for gene silencing. Mol. Cell. Oncol. 2 (2): e975633-1.
Dagnell, M., Frijhoff, J., Pader, I., Paten, A., Boivin, B., Mandal, P.J., Tonks, N.K., Hellberg, C., Conrad, M., Arner, E.S.J., Östman, A. (2013) Thioredoxin-mediated selective activation of oxidized PTP1B modulates PDGF-receptor tyrosine kinase signaling. Proc. Natl Acad. Sci. U.S.A. 110, 13398-13403.
Boivin, B., Chaudary, F., Dickinson, B., Haque, A., Pero, S., Chang, C., Tonks, N.K. (2013) Receptor Protein Tyrosine Phosphatase Regulates Focal Adhesion Kinase Phosphorylation and ErbB2 Oncoprotein-Mediated Mammary Epithelial Cell Motility. J. Biol. Chem. 288, 36926-36935.
Boivin, B., Yang, M., Tonks, N.K. (2010) Targeting the Reversibly Oxidized Protein Tyrosine Phosphatase Superfamily. Sci. Signal. 3, pl2.
Loh, K., Deng, H., Fukushima, A., Cai, X., Boivin, B., Galic, S., Bruce, C., Shields, B.J., Skiba, B., Ooms, L.M., Stepto, N., Wu, B., Mitchell, C.A., Tonks, N.K., Watt, M.J., Febbraio, M.A., Crack, P.J., Andrikopoulos, S., Tiganis, T. (2009) Reactive oxygen species enhance insulin sensitivity. Cell Metab. 10, 260-272.
Juarez, J.C., Manuia, M., Burnett, M.E., Betancourt, O., Boivin, B., Shaw, D.E., Tonks, N.K., Mazar, A.P., Doñate, F. (2008) Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling. Proc. Natl Acad. Sci. U.S.A. 105, 7147-7152
Boivin, B., Zhang S, Arbiser JL, Zhang ZY, Tonks NK. (2008) A modified cysteinyl labeling assay reveals reversible oxidation of protein tyrosine phosphatases in angiomyolipoma cells. Proc. Natl Acad. Sci. U.S.A. 105, 9959-9964.
Boivin B, Chevalier D, Villeneuve LR, Rousseau E, Allen BG. (2003) Functional endothelin receptors are present on nuclei in cardiac myocytes. J. Biol. Chem. 278, 29153-29163.
Boivin, B, Lavoie C, Vaniotis G, Baragli A, Villeneuve LR, Ethier N, Trieu P, Allen BG, Hébert TE. (2006) Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular myocytes. Cardiovasc. Res. 71, 69-78.
Boivin, B., Vaniotis, G., Allen, B.G., and Hébert, T. (2008) G protein-coupled receptors in and on the cell nucleus: a new signalling paradigm? J. Rec Sig. Trans. 28, 15-28
Additional Information
Awards & Honors
- Jacques-de-Champlain Excellence Award, Heart and Stroke Foundation
- Research Scholar Award (Junior 1), Fonds de Recherche du Quebec – Sante
- Heart and Stroke Foundation of Canada Fellowship
- Fonds de Recherche en Sante du Quebec Fellowship
- Cold Spring Harbor Association Fellowship