Biomedical Sciences Courses

Bms 500A Molecular Cell Biology A (2)

This course provides fundamental knowledge of cellular function at the molecular level. Topics covered: overview of genetics, genes and genomes, mechanisms of DNA replication in prokaryotes and eukaryotes; protein structure and function; nucleic acid structure and interactions with proteins. Prerequisites: Permission from Instructor.

Bms 500B Molecular Cell Biology B (2)

This course provides fundamental knowledge of cellular function at the molecular level. Topics covered: mechanisms of RNA transcription and regulation in prokaryotes and eukaryotes; structural and biochemical principles of "molecular machines", multi-subunit macromolecular complexes that use energy to perform their biological functions. Prerequisites: Permission from Instructor.

Bms 500C Molecular Cell Biology C (2)

This course provides fundamental knowledge of cellular function at the molecular level. Topics covered: gene silencing; RNA processing and function; protein translation; intracellular protein trafficking and proteolysis; membrane proteins. Prerequisites: Permission from Instructor.

Bms 502 Macromolecular Structure and Function (4)

The properties of macromolecules are examined, with an emphasis on how the three-dimensional structure of macromolecules determines their biological function, and how changes in structure (mutations & modifications) can cause changes in function.  Protein-protein, protein-nucleic acid, and protein-membrane interactions will be studied in depth.  Prerequisite: Undergraduate-level biochemistry course suggested.

Bms 504A Comprehensive Biochemistry (4)

Chemical characteristics of living matter, amino acids, polypeptides and proteins, supramolecular assembly and membrane structure; enzyme mechanisms and kinetics; bioenergetics and the chemistry of metabolism; electron transport and other transports across membranes; biosynthesis, storage, and expression of genetic information. Additional assignments will be required, including homework assignments. Prerequisite: Consent of instructor.

Bms 504B Comprehensive Biochemistry: Part B (3)

Focus is on cellular organization, organellar biogenesis and cellular trafficking the biochemical basis for representative human diseases resulting from the failure to properly assemble and target critical cellular components. Prerequisite: Bms 505A

Bms 505 Biological Basis of Public Health (3)

Introduction to field of biomedical sciences and public health, including infectious and transmissible vectors, genetic disease and chronic disorders. Explanation of laboratory based procedures for detection, monitoring, and treating such diseases. Concepts of basic, relevant laboratory methods and data interpretation introduced. Discussion of impacts of nanotechnology on biomedical sciences, medicine and public health. Prerequisite: College level biology or biochemistry or genetics or molecular biology or permission of instructor.

Bms 506 Introduction to Immunology (2)

Introduction to basic immunology with emphasis on the comprehensive aspects of humoral (antibody mediated) and cell-mediated immunity. A historical experiment approach will be provided to bring to the student presently accepted/believed concepts. Each two-hour session will be one hour of basic lecture followed by one-hour discussion of the assigned reading. Class will meet once per week to allow sufficient time to complete the reading assignment for each session. Prerequisite: Cell Biology or permission of course director.

Bms 510 Communication in Science (1)

This is an introductory course to promote effective scientific writing and data presentation skills. Specifically for writing journal articles, presenting posters and giving oral presentations based on graduate research. The course is restricted to students engaged in research.

Bms 511 Topics in Biomedical Spectroscopy (2)

Lectures and laboratory assignments on various types of biomedical instrumentation. Prerequisite: Course in basic biochemistry or biophysics.

Bms 514 (Amc 504) Cellular and Molecular Immunology (3)

Intermediate level immunology course covering the cellular and molecular basis of innate and adaptive immunity.  Prerequisite: Bms 506 or Permission of instructor.

Bms 526 Scientific Communication (1)

This course introduces students to effective scientific communication skills, including giving talks, presenting posters, and writing papers. This is achieved through in-class discussions, critiques of scientific papers, and student presentations and writings. Additional emphasis is placed on specialized activities performed by public health laboratorians, including communicating with non-scientific audiences.

Bms 527 Molecular Biology and Genetics (3)

This course presents an introduction to molecular methods and their use for identification and characterization of diseases. Topics covered include nucleic acid-based methods for diagnosis of genetic diseases and cancer, pharmacogenomics, personalized medicine, bioinformatics, and legal and ethical issues related to genetic testing. Method development and validation strategies are also described.

Bms 528 Microbiology and Infectious Disease (3)

This course provides a background of knowledge of the major human pathogens and the interactions of these organisms with the human host. Topics covered include the basic biology of bacteria, fungi, parasites and viruses, and the principal approaches to recognition of pathogens by modern diagnostic techniques.

Bms 529 Clinical Immunology Technology: Theory and Practice (2)

This course familiarizes students with the various immunological methods that are used for diagnosis of infectious diseases. It provides a fundamental understanding of the human immune system and immune-related diseases, including immunodeficiencies, autoimmune diseases, immunopathologies associated with infections, and hyperreactivities.

Bms 530 Data Analysis for Laboratory Sciences (2)

This course will expose students to data analysis methods used in the public health laboratory. Topics include a grounding in statistics, assay validation and performance, epidemiological analysis, next-generation sequencing, and phylogenetic data analysis in disease outbreak investigation.

Bms 549 Neurotransmitters (3)

Examination of the mechanisms and concepts of chemical transmission, emphasizing the regulatory mechanisms controlling synthesis, release, reuptake, and receptor activation for each of four classes: monoamines, acetylcholine, amino acids, and peptides. Neurotransmitter-related diseases and the involvement of transmitters and transmission in developmental processes such as synaptogenesis and synaptic stabilization. Prerequisite: graduate standing or consent of instructor.

Bms 550 Neural Plasticity in the Mammalian CNS (2)

A course designed to provide the theoretical and practical framework to investigate neural placticity in the CNS. Topics will include neurotransmitter/ion channel function, preparation of brain slices, and electrophysiological techniques. Prerequisite: Bio 547 or Bio 548, or equivalent.

Bms 551 Introduction to Genetics and Genomics (3)

This distance learning course is designed to introduce to students with no or minimal formal training in molecular genetics to the fields of genetics and genomics with an emphasis on their application in public health. Students will be prepared to use this information in their professions and take higher level courses if desired. Prerequisite: Basic undergraduate biology or permission of instructor.

Bms 552 Bioecology of Vector-borne Diseases (3)

This course will focus on the ecology and biology of insect and tick vectors of pathogens causing both tropical and temperate diseases such as malaria, Lyme disease, African sleeping sickness, Chagas' disease, yellow fever, chikungunya and West Nile virus.  We may also introduce forensic entomology, depending on class size.  Prerequisite: Permission of instructor.

Bms 553 Virology (4)

A general virology survey covering all aspects of structure, replication, and pathogenesis of viruses important in public health. Prerequisites: Cell Biology and Biochemistry.

Bms 555 Biodefense Sciences (1)

Students will be given a working knowledge of the morphology, pathology, treatment, and prevention of potential biological threat agents as well as an understanding of procedures and methods to safely and securely work with these agents in the laboratory. Overviews and appropriate use of diagnostic methods will be presented. Prerequisite: Undergraduate biology and chemistry.

Bms 556 Biodefense Laboratory Sciences (1)

This course will provide an introduction to the procedures and methods to safely and securely work with these agents in the laboratory. Overviews and use of diagnostic methods will be presented including culture, immunoassay and nucleic acid amplification. The laboratories are designed to give students an understanding of the testing flow used for biothreat analysis and emerging infectious disease as well as some of the specialized techniques and technology that the Wadsworth Center has used in real-world testing of these types of samples. The students will take analysis from the beginning stages of specimen/sample arrival through rapid and confirmatory testing that will be taught throughout the laboratories. Prerequisite: Undergraduate biology and chemistry.

Bms 557 Biomedical Sciences: Emerging Infectious Diseases (1)

Students will gain fundamental knowledge of emerging infectious pathogens, ranging from epidemiology, molecular biology, pathogenesis, transmission, and interventions. The emphasis of the course will be on the impact of these pathogens on public health, and their interventions and preventions. Prerequisites: Undergraduate microbiology or permission of instructor.

Bms 560 Introduction to Macromolecular Three-Dimensional Structure Analysis (2)

Overview of the methods of three-dimensional structure determination of biological macromolecules by X-ray crystallography and nuclear magnetic resonance spectroscopy.

Bms 570A (Chm 544, Phy 544) Theory and Techniques of Biophysics and Biophysical Chemistry (3)

Comprehensive study of the physical chemistry of biopolymers; structure- confirmation-function interrelations, including systematic coverage of theoretical and experimental aspects of such topics as solution thermal dynamics, hydrodynamics, and optical and magnetic characteristics. Prerequisites: One year of biochemistry and one year of physical chemistry.

Bms 575 Structure of Microbial Pathogens (3)

Lecture course covering the structure of bacteria, fungi and viruses, with emphasis on how this information relates to overcoming the different types of pathogens. Prerequisite: Course in basic biology.

Bms 590 Laboratory Rotations in Biomedical Sciences (3)

Introduction to different aspects of biomedical research ongoing in the department; introducing students to various faculty members and a variety of experimental methodologies and research approaches. Prerequisite: Permission of course director.

Bms 601 Biomedical Science Horizons (3)

This course will discuss important concepts for students considering a future career in biomedical sciences and public health.  Students will gain an understanding of cutting edge technologies in molecular biology, genomics, proteomics, and cell biology and their role in future improvements in public health.  Students will also become familiar with the all important first step in future biomedical public health studies: scientific proposal writing and review.

Bms 603 HIV and AIDS Colloquium (2)

Using recent reviews and the current literature, important topics in HIV and AIDS will be covered. Topics will include, but are not limited to, the virus, its replication and its effect on the host in vitro; virus pathogenesis and disease progression; effects of virus infection on the immune system; chemotherapy of viral infections; viral vaccines; opportunistic infections; and methods of detection of HIV. Participating students will be encouraged to suggest topics for discussion. Prerequisite: Graduate virology course.

Bms 604 Cellular and Molecular Neuroscience (3)

This course introduces the student to the cells of the central and peripheral nervous systems, both neurons and glia. It covers both electrical and chemical aspects in signalling in the nervous system. Some model neurotransmitter systems are examined in detail. Integrative material on learning and memory in simple systems is presented.

Bms 606 Model Organisms in Biomedical Research (3)

Course will use current literature to emphasize the importance of model organisms for studying fundamental principles of biology. Topics to be covered will include: genetic suppression, mosaic analysis, microinjection methods; inhibition of dsRNA (RNAi), analysis of transgenic organisms, intracellular localization of macromolecules, eukaryotic cell cycle, lineage analysis. Prerequisites: Bms 500 or equivalent; and Bms 504a or equivalent.

Bms 609 Immunochemistry of Microbial Molecules (1)

Tutorial: current knowledge and strategies and methods for immunochemical analysis of important microbial molecules. Emphasis on procedures applicable in molecular genetics that use calibrated poly- and monoclonal antibody probes to study native and recombinant gene products.

Bms 610 Microbial Pathogenesis (3)

This course will provide students with a background in the mechanisms of microbial pathogenesis. Students will learn basic principles of host- parasite interactions and how human behavior has influenced both the resurgence of old diseases and the emergence of new ones. Paradigms of host-parasite interactions will be illustrated by studying, at the molecular and cellular levels, specific infectious diseases and the agents that cause them.

Bms 612 Neuroanatomy and Nervous System Disorders (3)

Examination of the neural basis of disorders as Parkinson's disease, epilepsy, Alzheimers, etc. Prerequisite: graduate standing.

Bms 614A (Bio 614A) Theory and Practice of Electron Microscopy I: Basic Techniques (2)

Basic theory of electron microscopic image formation, design and operation of transmission electron microscope, and principles of conventional specimen preparation. Specialized techniques (elemental analysis, high-voltage electron microscopy, computer analysis, and 3D reconstruction) will be introduced, as well as biomedical and public health applications of electron microscopy. One 2-hour lecture per week. Prerequisite: Permission of instructor.

Bms 614B (Bio 614B) Laboratory on Basic Techniques of Electron Microscopy (2)

Laboratory course corresponding to topics covered in Bms 614A (Bio 614A). Classes will cover plastic embedding and then sectioning of tissue, negative staining, metal shadowing, critical paint drying, operation of a transmission electron microscope and photographic darkroom procedures. one 4-hour laboratory per week. Prerequisite: Permission of instructor.

Bms 615 Theory and Practice of Macromolecular Crystallography (3)

In depth coverage of the theory and practice of macromolecular crystallography. Students will become familiar with the methods of crystallization, data collection, structure determination, refinement and analysis. Course will consist of lectures and laboratory demonstrations. Prerequisite: Permission of instructor.

Bms 619  (Bio 619) Chemical Principles in RNA Biology (3)

Physical and chemical principles will be exemplified by biological systems, especially those involving RNAs. Topics cover many aspects of RNA, including RNA synthesis, modification, folding, function and catalysis; protein/ligand-RNA interaction. The course will also emphasize physical, chemical, and molecular techniques used in RNA studies, including structural prediction and determination, thermodynamics and spectroscopy, modern sequencing techniques. Prerequisite: Secondary year graduate students from science disciplines with good academic standing are encouraged to take the course. Consent of instructor required.

Bms 622 (Ehs 630) Cancer Biology (3)

This course will introduce second year students to the complexity of cancer as a disease. It will focus on the basic molecular cell biology mechanisms that underlie the origin and progression of cancer, the epidemiological aspects and the principles of clinical management of the disease. Prerequisites: Basic undergraduate biology; Bms 500 and Bms 500B or equivalents; or permission of instructor.

Bms 625 Light Optics in Biomedical Science (3-4)

Lecture and demonstration course covering the optical systems (imaging and spectroscopic) most frequently used in biomedical applications. Prerequisite: Undergraduate physics course or permission of instructor.

Bms 627 (Bio 627) Theory and Practice of Scanning Electron Microscopy (2)

An introduction to the theory and basic techniques for specimen preparation and viewing in the scanning electron microscope. Students learn to fix, dehydrate, critical-point dry, mount and coat standard samples and encouraged, where possible, to work with their own material as well. Discussion and demonstration of more specialized techniques where appropriate. Students learning to use the microscope are encouraged to achieve "independent operator" status as soon as possible. Quarter course. Hours arranged: two one-hour lectures, one formal three-hour laboratory per week.

Bms 631 Demystifying the RNA World (2)

Students will be introduced to the diversity of RNA molecules and their functions in the cell. An interdisciplinary approach to understand RNA structure and function will be taken. Topics will include: RNA secondary and tertiary structure, RNA modifications, ribonucleoprotein complexes, non-coding RNAs, parasitic RNAs, catalytic RNAs and RNA interference

.Bms 632 Molecular and Cellular Biology of Prokaryotes (3)

Bms 632 is intended to provide insightful knowledge into the molecular and cellular biology of prokaryotes and to emphasize the importance of bacteria as model organisms for studying molecular processes.  Specific topics in critical areas will be discussed using the current literature to emphasize the diversity and ubiquitous nature of the bacterial world. Prerequisites: Bms 500 or equivalent; and Bms 504a or equivalent.

Bms 635 Introduction to Structural Molecular Biology (3)

Bms 635 covers principles and applications of contemporary Structural Biology methods to examine macromolecules and protein assemblies in size from 1000's of Angstroms down to the atomic level.  The goal is to provide students with a general understanding of current techniques most appropriately suited for the broad range of problems in contemporary biomedical research.

Bms 638 Orgenelle Biogenisis and Intracellular Trafficking (1)

This course will describe the structure, function, and vesicular communication network operating among the organelles found in eukaryotic cells. The role of cell specialization and post-translational protein modifications on organellar targeting and trafficking of essential cellular components will be explored.

Bms 640 Cellular Dynamics (3)

This course will examine the dynamic processes involved with cell structure and function. Faculty and students will participate in presenting literature and in depth discussion of 3 to 5 topics relevant to the research interests of the participants. Prerequisite: One semester of graduate cell biology.

Bms 642 Biomembranes (3)

Physical, biophysical, and biochemical insights into biological membranes including membrane proteins, channels, membrane potential, model membranes, methods of analysis, organelles and membrane-related diseases. Prerequisite: Graduate-level biochemistry or biophysics course.

Bms 644 Fundamentals of Pharmacology (2)

An introduction to the principles by which drugs and other bioactive substances are absorbed, distributed, metabolized and act on biological systems. Topics include drug-receptor interactions, drug-effector interactions and pharmacokinetics. Prerequisite: Bms 504a or equivalent.

Bms 646A Current Topics in Neuroscience: Neurobiology of Aging (2)

Advanced course in neuroscience covering the age-related changes in the function of the nervous system. Course will cover mechanisms of normal memory, circadian-rhythms, movement and automatic functions and the alterations thereof; premature aging and dementias. Prerequisite: Graduate course in basic neuroscience or consent of instructor.

Bms 648 Neurophysiology (2)

This course will provide an overview on the fundamentals of electrical signaling in excitable cells. The objective of the course will be to provide students with tools to understand and critically evaluate electrophysiology work. Levels of analysis presented will range from membrane and ion channel biophysics to systems and behavioral electrophysiology. Prerequisite: Bms 604 or equivalent.

Bms 650 Readings in Neuroscience (1-3)

Advanced reading on specific topics of interest, under the director of individual faculty members. Discussions emphasize critical analysis and synthesis. Prerequisite: Permission of instructor.

Bms 652 Neuroimmunology Colloquim (2)

An advanced course designed to examine the multiple bidirectional interactions between the central nervous system and the immune system. Topics will include neurotransmitter and neuropeptide effects on cells of the immune system, cytokine regulation of brain functions, innervation of immune organs and the consequences thereof, brain laterality influences on immune functions, conditioning effects on immune responses, and immunopathologies of the central nervous system. Prerequisites: Graduate level cell biology, and Bms 506or Bms 514.

Bms 655 NanoBioTechnology (3)

To introduce the principles of Micro and Nano fabrication for the study of biological systems. Fabrication methods and the principles of interfacing biology to miniature devices will be stressed.

Bms 658 (Ehs 658) Modern Scanning Electron Microscopy (3)

An advanced course designed to introduce theoretical and practical aspects of operating state-of-the-art scanning electron microscopes. Topics will include sample preparation, secondary, backscatter and other electron imaging modes, X-ray microanalysis and element mapping and image interpretation. Prerequisites: Bms 500, Ehs 590, or permission of instructor.

Bms 660 Readings in Molecular Endocrinology (3)

Tutorial course to present current literature in the biochemistry, physiocology and molecular biology of steriod and polypeptid hormone action. Prerequisites: Bms 500, 504a, 504b and permission of instructor.

Bms 662 Student Seminars in Biomedical Sciences (1)

This course will train students to present their current research effectively, and to give constructive and thoughtful feedback for other student presentations.  It will provide timely and useful feedback on the ideas and progress of their thesis research.  All students will present once per semester.  Prerequisites: Satisfactory completion of one laboratory rotation.

Bms 663 Mammalian Molecular Genetics (3)

This course will cover topics related to the structure and function of the of the mammalian genome and the molecular mechanisms involved in development, cell fate determination and cellular differentiation. Students will participate by presenting research papers relevant to a current topic. Prerequisite: Bms 500 and 605A, or equivalent.

Bms 665 Current Literature in Biomedical Sciences (0-1)

A course designed to teach and promote critical reading of the literature. Multiple sections are offered each semester including immunology, infectious disease, biochemistry, molecular biology, genetics, structural and computational biology, and neuroscience. Additional sections are mounted as student and faculty interest direct. All students must register for this course.

Bms 666 Contemporary Topics in Immunology (0-1)

This is an advanced course that is designed to explore central questions and concepts in immunology through readings and discussion of the current scientific literature. Topics of special interest will be selected and reviewed per semester. Participants will be involved in the selection and presentation of the literature. Prerequisite: Bms 514 or equivalent, or by permission of instructor.

Bms 670 (Ehs 675) Responsible Conduct of Scientific Research (1)

This is a required course which will explore specific areas of the conduct of research. Aspects of recognition of scientific fraud, peer interaction, and reporting of misconduct will be covered. Bioethical issues will not be covered. A specific issue concerning scientific conduct will be presented at each class through case study and student- led discussion. S/U graded.

Bms 672 Current Methods in Biomedical Sciences (1)

This course will cover an array of methods currently being used in biomedical research. Students will learn when to choose a certain method and how to recognize its benefits and shortcomings. Prerequisites: Enrollment in the BMS, PhD or MS graduate program, or by permission of instructor.

Bms 690 Biomedical Science Research (2-12)

Supervised research in an area of biomedical sciences. Prerequisite: Consent of department chair. S/U graded.

Bms 692 Advanced Topics in Biomedical Sciences (1)

Advanced topics related to research within the diverse field of biomedical sciences.  Lectures will be largely based on primary literature, with additional background information covered as needed.  Additional sections are mounted as student and faculty interest direct.  May be repeated multiple times as long as topics differ.  Prerequisite: Permission of instructor.

Bms 694 Directed Readings in Biomedical Sciences (1-6)

Projects in selected areas of biomedical sciences at the Masters level, under supervision of a faculty member, with regular progress reports. May be repeated once when topics differ for a total accumulation of 6 hours. Prerequisite: Consent of department chair. S/U graded.

Bms 699 Thesis Research (1-12)

Required of all master's students. Prerequisite: Consent of advisor.

Bms 851 Advanced Techniques in Structural Analysis (1-4)

Tutorial course to provide advanced training in one or two specialized techniques of electron or light microscopy or biophysics. Prerequisites: Bms 614, Bms 570 or equivalent experience and permission of instructor.

Bms 894 Directed Readings in Biomedical Sciences (1-6)

Projects in selected areas of biomedical sciences, under supervision of a faculty member, with regular progress reports. This course may be repeated multiple times, when topics differ for a total accumulation of 6 hours. Prerequisite: Consent of department chair. S/U graded.

Bms 898 Doctoral Project (1-12)

Available for all Ph.D. students engaged in research leading to the dissertation, prior to candidacy.

Bms 899 Dissertation Research (1-12)

Required of all Ph.D. students. Prerequisite: Consent of advisor. Registration for this course is limited to doctoral students who have been admitted to candidacy.