My research program combines bioinformatic and molecular evolutionary methods to study the evolution of mammalian genes and genomes, with an emphasis on the primates. Our current projects include: (1) identifying genetic changes unique to the human and chimpanzee lineages; (2) understanding the genetic basis of SIV/HIV resistance in certain African primate species; and (3) studying the evolution of the lysozyme multigene family in the mammals, especially as related to fertilization. At present, our research is primarily computational.
I study experimental evolution by using microorganisms, particularly bacteriophage, as a model system. Currently my research focuses on two areas: (1) the genetic basis for the evolution of life history traits, with phage lambda as a model system, and (2) the identification of bacterial enzymes targeted by ssRNA phage lysis proteins.