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Research Publications

61. Haruehanroengra P, Zheng Y, Zhou Y, Huang Y,* Sheng J*. RNA Modifications and Cancer. RNA Biology. 2020, Accepted.

60. Valsangkar VA, Chandrasekaran AR, Zhuo L, Mao S, Lee GW, Kizer M, Wang X, Halvorsen K*, Sheng J*. Click and photo-release dual-functional nucleic acid nanostructures. Chem Commun. 2019, 55(65): 9709-9712.

59. Chandrasekaran AR, Abraham Punnoose J, Valsangkar V, Sheng J, Halvorsen K. Integration of a photocleavable element into DNA nanoswitches. Chem Commun. 2019, 55(46): 6587-6590.

58. Ong AAL, Toh DK, Patil KM, Meng Z, Yuan Z, Krishna MS, Devi G, Haruehanroengra P, Lu Y, Xia K, Okamura K, Sheng J, Chen G. General Recognition of U-G, U-A, and C-G Pairs by Double-Stranded RNA-Binding PNAs Incorporated with an Artificial Nucleobase. Biochemistry. 2019, 58(10):1319-1331.

57. Mao S, Ranganathan SV, Tsai HC, Haruehanroengra P, Shen F, Valsangkar VA, Han B, Hassan AEA, Chen A, Sheng J*. Cyano-modification on Uridine Decrease the Base Pairing Stability and Specificity through Neighbouring Disruption in RNA Duplex. Chembiochem. 2018, 19(24):2558-2565..

56. Liu H, Wang R, Yu X, Shen F, Lan W, Haruehanroengra P, Yao Q, Zhang J, Chen Y, Li S, Wu B, Zheng L, Ma J, Lin J, Cao C, Li J, Sheng J*, Gan J*. High-resolution DNA quadruplex structure containing all the A-, G-, C-, T-tetrads. Nucleic Acids Res. 2018, 46(21):11627-11638.

55. Zhang Y, Wang C, Huang W, Haruehanroengra P, Peng C, Sheng J, Han B, He G. Application of organocatalysis in bioorganometallic chemistry: asymmetric synthesis of multifunctionalized spirocyclic pyrazolone–ferrocene hybrids as novel RalA inhibitors. Organic Chemistry Frontiers. 2018, 5, 2229-2233.

54. Wang R, Ranganathan SV, Haruehanroengra P, Mao S, Scalabrin M, Fabris D, Chen A, Liu H, Hassan AEA, Gan J, Sheng J*. Construction and structure studies of DNA-bipyridine complexes as versatile scaffolds for site-specific incorporation of metal ions into DNA. J. Biomol. Struct. Dyn. 2018, Feb 22:1-11. doi: 10.1080/07391102.2018.1441071.

53. Guallar D, Bi X, Pardavila JA, Huang X, Saenz C, Shi X, Zhou H, Faiola F, Ding J, Haruehanroengra P, Yang F, Li D, Sanchez-Priego C, Saunders A, Pan F, Valdes VJ, Kelley K, Blanco MG, Chen L, Wang H, Sheng J, Xu M, Fidalgo M, Shen X, Wang J. RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells. Nature Genetics. 2018, 50, 443-451.

52. Liu H, Yu X, Chen Y, Zhang J, Wu B, Zheng L, Haruehanroengra P, Wang R, Li S, Lin J, Li J, Sheng J, Huang Z, Ma J, Gan J. Crystal structure of an RNA-cleaving DNAzyme. Nature Communications, 2017, 8, 2006.

51. Liu H, Shen F, Haruehanroengra P, Yao Q, Cheng Y, Chen Y, Yang C, Zhang J, Wu B, Luo Q, Cui R, Li J, Ma J*, Sheng J*, Gan J*. A novel DNA structure containing AgI-mediated G:G and C:C base pairs. AngewChemInt. EdEngl, 2017, 56, 9430-9434.

50. Haruehanroengra P, Vangaveti S, Ranganathan S V, Wang R, Chen A, Sheng J.* Nature's selection of geranyl group as a tRNA modification: the effects of chain length on base-pairing specificity. ACS Chemical Biology, 2017, 12, 1504-1513.

49. Valsankar V A, Chandrasekaran A R, Wang R, Haruehanroengra P, Levchenko O, Halvorsen K*, Sheng J*. Click-based functionalization of a 2'-O-propargyl-modified branched DNA nanostructure. Journal of Materials Chemistry B, 2017, 5, 2074-2077.

48. Shen F, Luo Z, Wang R, Liu H, Zhang S, Gan J*, Sheng J*. Structural insights into RNA duplexes with multiple 2'-5'-linkages. Nucleic Acids Research, 2017, in press. DOI: 10.1093/nar/gkw1307.

47. Liu H, Cai C, Haruehanroengra P, Yao Q, Cheng Y, Yang C, Luo Q, Wu B, Li J, Ma J*, Sheng J*, Gan J.* Flexibility and Stabilization of HgII-mediated C:T and T:T base pairs in DNA duplex. Nucleic Acids Research, 2017, 45, 2910-2918.

46. Wang R, Haruehanroengra P, Sheng J.* Synthesis of Geranyl-2-thiouridine modified RNA. Current Protocols in Nucleic Acid Chemistry. 2017, 68:4.72.1-4.72.13.

45. Basanta-Sanchez M, Wang R, Liu Z, Ye X, Li M, Shi X, Agris P, Zhou Y, Huang Y*, Sheng J*. TET1-mediated Oxidation of 5-formylcytosine (5fC) to 5-carboxycytosine (5caC) in RNA. ChemBioChem. 2017, 18, 72-76.

44. Wang R, Vangaveti S, Ranganathan S V, Sanchez M B, Haruehanroengra P, Chen A, Sheng J.* Synthesis, base pairing and structure studies of geranylated RNA. Nucleic Acids Research, 2016, 44, 6036-6045.

43. Wang R, Luo Z, He K, Delaney MO, Chen D, Sheng J.* Base pairing and structural insights into the 5-formylcytosine in RNA duplex. Nucleic Acids Research, 2016, 44, 4968-4977.

42. Agustin E, Asare Okai PN, Khan I, Miller MR, Wang R, Sheng J, Royzen M. A fast click-slow release strategy towards the HPLC-free synthesis of RNA. Chemical Communications, 2016, 52, 1405-1408.

41. Robertson NM, Toscano AE, LaMantia VE, Hizir MS, Rana M, Balcioglu M, Sheng J, Yigit MV. Unlocked Nucleic Acids for miRNA detection using two dimensional nano-graphene oxide. Biosens. Bioelectron. 2016, pii: S0956-5663(16), 30164-30166.

40. Hizir MS, Top M, Balcioglu M, Rana M, Robertson NM, Shen F, Sheng J, Yigit MV. Multiplexed Activity of perAuxidase: DNA-Capped AuNPs Act as Adjustable Peroxidase. Anal. Chem. 2016, 88, 600-605.

39. Wang R, Ranganathan S V, Valsankar V A, Magliocco S M, Shen F, Chen A, Sheng J.* Water-bridged hydrogen bond formation between 5-hydroxylmethylcytosine (5-hmC) and its 3’-neighbouring bases in A- and B-form DNA duplexes. Chemical Communications, 2015, 51, 16389-16392.

38. Wang R, Ranganathan S V, Sanchez M B, Shen F, Chen A, Sheng J.* Synthesis and Base Pairing Studies of Geranylated 2-thiothymidine, a Natural Variant of Thymidine. Chemical Communications, 2015, 51, 16369-16372.


37. Larsen A, Fahrenbach A C, Sheng J, Pian J, Szostak J W. Thermodynamic Insights into 2-thiouridine-enhanced RNA hybridization. Nucleic Acids Research, 2015, 43, 7675-7687.

36. Sheng J, Larsen A, Heuberger B D, Blain J C, Szostak J W. Crystal Structure Studies of RNA Duplexes Containing S2U:A and S2U:U Base Pairs. J. Am. Chem. Soc. 2014, 136, 13916-13924.

35. Sheng J, Li L, Engelhart A E, Gan J, Wang J, Szostak J W. Structural Insights into the Effects of 2’-5’ linkages on the RNA Duplex. Proc. Natl. Acad. Sci. U.S.A, 2014, 111, 3050-3055.

34. Sheng J, Gan J, Huang Z. Structure-Based DNA-Targeting Strategies with Small Molecule Ligands for Drug Discovery. Medicinal Research Reviews, 2013, 33, 1119-1173.

33. Sheng J, Gan, J, Soares, A, Salon, J, Huang Z. Structural Insights of Non-canonical U-U Pair and Hoogsteen Interaction Probed with Se Atom. Nucleic Acids Research, 2013, 41, 10476-10487.

32. Sheng J, Zhang W, Hassan A, Gan J, Soares A, Geng S, Ren Y, Huang Z. Hydrogen Bond Formation between the Naturally Modified Nucleobase and Phosphate Backbone. Nucleic Acids Research, 2012, 40, 8111-8118.

31. Sheng J, Huang Z. Selenium Derivatization of Nucleic Acids for X-ray Crystal-Structure and Function Studies", Chemistry and Biology of Artificial Nucleic Acids, 2012, 329-361.

30. Sun H, Sheng J, Hassan A, Jiang S, Gan J, Huang Z. Novel RNA Base Pair with Higher Specificity Using Single Selenium Atom. Nucleic Acids Research, 2012, 40, 5171–5179.

29. Zhang W, Sheng J, Hassan A, Huang Z. Synthesis of novel 2’-Deoxy-5-(Methylselenyl)Cytidine and Se-DNAs for Structure and Function Studies. Chemistry-An Asian Journal, 2012, 7, 476-479.

28. Jiang S,  Sheng J, Huang Z. Synthesis of the Tellurium-Derivatized Phosphoramidites and their Incorporation into DNA Oligonucleotides. Current Protocols in Nucleic Acid, 2012, 1.25.1-1.25.16

27. Sheng J, Hassan A, Zhang W, Zhou J, Xu B, Soares A, Huang Z. Synthesis, structure and imaging of oligodeoxyribonucleotides with tellurium-nucleobase derivatization. Nucleic Acids Research, 2011, 39, 3962-3971.

26. Lin L, Sheng J, Huang Z. "Nucleic Acid X-ray Crystallography via Direct Selenium Derivatization", Chemical Society Reviews, 2011, 40, 4591.

25. Dai C, Wang L, Sheng J, Peng H, Draganov A, Huang Z, Wang B. The First Chemical Synthesis of Boronic Acid-modified DNA through Copper-free Click Reaction. Chemical Communications, 2011, 47, 3598-3600.

24. Zhang W, Sheng J, Huang Z. Structures and Functions of Nucleic Acids Modified with S, Se and Te and Complexed with Small Molecules. Medicinal Chemistry of Nucleic Acids, 2011, 101-141.

23. Gan J, Sheng J, Huang Z. Chemical and Structural Biology of Nucleic Acids and Protein-nuclei Acid Complexes for Novel Drug Discovery. Science in China B: Chemistry, 2011, 54 (1), 3-23.

22. Lin L, Williams J, Kaur M, Patino A, Sheng J, Punetha J, Huang Z. Facile Synthesis of Nucleoside 5’-(α-P-seleno)-triphosphates and Phosphoroselenoate RNA Transcription", RNA, 2011, 17, 1932-1938.

21. Sheng J, Salon J, Gan J, Huang Z. Synthesis and Crystal Structure Study of 2’-Se-adenosine Derivatized DNA. Science in China B: Chemistry, 2010, 53(1), 78-85.

20. Hassan A, Sheng J, Zhang W, Huang Z. High Fidelity of Base Paring by 2-Selenothymidine in DNA. Journal of American Chemical Society, 2010, 132, 2120-2121.

19. Salon J, Sheng J, Gan J, Huang Z. Synthesis and Crystal Structure of 2’-Se-modified Guanosine Containing DNA. The Journal of Organic Chemistry, 2010, 75, 637-641.

18. Sheng J, Huang Z. Selenium Derivatization of Nucleic Acids for Structure and Function Studies, Chemistry and Biodiversity, 2010, 7, 753-785.

17. Sheng J, Hassan A, Huang Z. Synthesis of the First Tellurium-Derivatized Oligonucleotides for Structural and Functional Studies. Chemistry—A European Journal, 2009, 15 (39), 10210-10216.

16. Hassan A, Sheng J, Jiang J, Zhang W, Huang Z. Synthesis and Crystallographic Analysis of 5-Se-thymidine DNAs. Organic Letters, 2009, 11, 2503-2506.

15. Lin L, Sheng J, Momin R, Du Q, Huang Z. Facile synthesis and anti-tumor cell activity of Se-containing nucleosides. Nucleosides, Nucleotides and Nucleic Acids, 2009, 28, 56-66.

14. Sheng J, Hassan A, Huang Z. Telluride-Mediated Elimination and Novel Synthesis of 2’,3’-Didehyro-2’,3’-dideoxynucleosides (d4Ns). The Journal of Organic Chemistry, 2008, 73(10), 3725-3729.

13. Sheng J, Huang Z. Synthesis of a 4-Se-Thymidine Phosphoramidite and Incorporation into Oligonucleotides. Current Protocols in Nucleic Acid Chemistry, 2008, 32: 1.19.1-1.19.13.

12. Salon J, Jiang J, Sheng J, Gerlits O, Huang Z. Derivatization of DNAs with Selenium at 6-Position of Guanine for Function and Crystal Structure Studies, Nucleic Acids Research, 2008, 36, 7009-7018.

11. Sheng J, Huang Z. Selenium Derivatization of Nucleic Acids for Phase Determination in Nucleic Acid X-ray Crystallography, International Journal of Molecular Sciences, 2008, 9, 258-271.

10. Salon J, Sheng J, Jiang J, Chen G, Caton-Williams J, Huang Z. Oxygen Replacement with Selenium at the Thymidine 4-position for the Se Base Paring and Crystal Structure Studies. Journal of American Chemical Society, 2007, 129, 4862-4863.

9. Jiang J, Sheng J, Carrasco N, Huang Z. Selenium Derivatization of Nucleic Acids for Crystallography. Nucleic Acids Research, 2007, 35, 477-485.

8. Sheng J, Jiang J, Salon J, Huang Z. Synthesis of a 2’-Se-Thymidine Phosphoramidite and Its Incorporation into Oligonucleotides for Crystal Structure Study. Organic Letters, 2007, 9, 749-752.

7. Wang L*, Sheng J, Zhang L, Han J, Fan Z, Tian H. Facial Yb(OTf)3 Promoted One-Pot Synthesis of Polyhydroquinoline Derivatives Through Hantzsch Reaction. Tetrahedron, 2005, 61, 1539-1543.

6. Wang L*, Han J, Tian H, Sheng J, Fan Z, Tang X. Rare earth Perfluorooctanoates[RE(PFO)3]-catalyzed Condensations of Indole with Carbonyl Compounds, Synlett, 2005, 2, 337-339.

5. Wang L*, Han J, Sheng J, Tian H. Rare Earth Perfluorooctanoate [RE(PFO)3] Catalyzed One-pot Mannich Reaction: Three Component Synthesis of β-Amino Carbonyl Compounds, Catalysis communications, 2005, 6 (3), 201-204.

4. Wang L*, Sheng J, Zhang L, Han J, Fan Z, Tian H. Solvent-free Knoevenagel Condensation Catalyzed by Yb(OTf)3. Chinese Journal of Organic Chemistry, 2005, 25, 964-968.

3. Wang L*, Sheng J, Tian H, Han J, Fan Z, Qian C. A Convenient Synthesis of α,α’-Bis(substituted benzylidene) cycloalkanones Catalyzed by Yb(OTf)3 Under Solvent-free Conditions. Synthesis, 2004, 18, 3060-3064.

2. Wang L*, Sheng J, Tian H, Qian C. An Efficient Procedure for the Synthesis of Benzimidazole Derivatives Using Yb(OTf)3 as Catalyst under Solvent-free Conditions. Synthetic Communications, 2004, 34, 4265-4272.

1. Wang L*, Sheng J, Tian H. Yb(OTf)3 Catalyzed Synthesis of Advanced Organic synthesis Reaction. Journal of the Chinese Rare Earth Society, 2004, 22 (6), 725-733.



6. Zhen Huang, Jia Sheng, Title: “Improved Method and Process for Synthesis of 2’,3’-Didehyro-2’,3’-dideoxynucleosides (d4Ns)”, 2010, US Patent Application No. 12/933,619 (National Phase Filing of PCT/US09/37823).

5. Zhen Huang and Jia Sheng, Title: “Novel Compounds and Synthesis of Tellurium-derivatized Oligonucleotides for Structural and Functional Studies”, 2010, PCT/US10/36639.

4.  Zhen Huang, Abdalla Hassan, Jia Sheng and Wen Zhang, Title: “Novel Compound and Derivatizaton of DNAs and RNAs on the Nucleobases of Pyrimidines for Function, Structure and Therapeutics”, 2010, PCT/US10/35631.

3. Zhen Huang, Jia Sheng and Abdalla Hassan, Title: “Novel Compounds and Derivatization of DNAs and RNAs at the 2' and 5-positions of pyrimidines with tellurium functionalities for function, structure, imaging, diagnosis, and therapeutics”, 2009, US Provisional Patent Application, 61/182,580.

2.  Limin Wang, Zhao-Yu Fan, Jianwei Han, Jia Sheng, He Tian. “Synthesis of novel cationic silicon type dye-fixatives with high activities”. Patent Application No. 200410025014.5 Patent No. ZL200410025014.5,  June-14, 2006.

1.   Limin Wang, Jianwei Han, Zhao-Yu Fan, He Tian, Jia Sheng. Synthesis of Rare Earth Lewis Acids Catalysts with long perfluoro-chain. Application No. 200410024683.0 Patent No. ZL200410024683.0, Mar-07, 2007.