He works in moral and political philosophy. His interests extend to all parts of the subject, including meta-ethics, normative ethics, political philosophy, philosophy of law, and philosophy of action. Zylberman also works on the history of the discipline, in particular on Kant's practical philosophy. He has written about the foundations of human rights, the nature of rights, authority, lying, consequentialism and deontology, global justice, human dignity, respect, the moral ought, relational normativity, Kant's philosophy of right, and Kant's meta-ethics. His current project is at the intersection of metaphysics and moral philosophy and seeks to investigate the possibility of a relational metaphysics of morals, that is, an account of the nature of moral personhood and moral norms according to which the human being is only fully constituted by interpersonal relations. The historical counterpart of this project is a fundamental re-reading along relational lines of Kant's account of morality.