The Upstate KIDS Study tracked the growth, motor, and social development of children to examine associations with parental medical conditions and characteristics, including infertility treatments, environmental, and other exposures. From 2008 to 2010, over 5,034 mothers and their 6,171 children born from the 57 counties of New York State (exclusive of New York City) joined this important study.
Methods
Questionnaires were collected from mothers when the children were 4, 8, 12, 18, 24, 30, and 36 months old. A subgroup of 600 infants was evaluated at 36-48 months for neurodevelopmental outcomes. In addition, with parental consent, residual dried blood samples were analyzed for inflammatory and environmental chemical biomarkers. The aim of the second follow-up period for children aged 7-10 was to evaluate cardio-metabolic risk factors and development. Parents received annual questionnaires and were invited for clinical exams and saliva collection programs.
Upstate KIDS Newsletters
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Papers from Upstate KIDS
Environmental Exposures measured in Newborn Dried Blood Spots
- Exposure to persistent organic pollutants and birth characteristics: The Upstate KIDS Study
- Analysis of polychlorinated biphenyls (PCBs) and organochlorine pesticides in archived dried blood spots and its application to track temporal trends of environmental chemicals in newborns
- Temporal trends of polybrominated diphenyl ethers (PBDEs) in the blood of newborns from New York State during 1997 through 2011: analysis of dried blood spots from the newborn screening program
- Analysis of polyfluoroalkyl substances and bisphenol A in dried blood spots by liquid chromatography tandem mass spectrometry
- Association between maternal smoking and interleukin-8 as measured with newborn dried blood spots in a U.S. birth cohort
- Concentrations of perfluoroalkyl substances and bisphenol A in newborn dried blood spots and the association with child behavior
- Concentrations of endocrine disrupting chemicals in newborn blood spots and infant outcomes in the upstate KIDS study
Markers of Immune Function measured in Newborn Dried Bloodspots
- Maternal smoking and newborn cytokine and immunoglobulin levels
- Concentrations of immune marker in newborn dried blood spots and early childhood development
- Detection of immunoglobulin isotypes from dried blood spots
- Newborn adipokines and birth outcomes
- Impact of Parental Obesity on Neonatal Markers of Inflammation and Immune Response
- Determinants of neonatal Brain Derived Neurotrophic Factor and its association with child development
- Newborn adipokines and early childhood growth
Study Design and Methods
- Methodology for Establishing a Population-Based Birth Cohort Focusing on Couple Fertility and Children’s Development, the Upstate KIDS Study
- Use of assisted reproductive technologies treatment as reported by mothers in comparison to registry data, Upstate KIDS Study
- Accuracy of self-reported survey data on assisted reproductive technology treatment parameters and reproductive history
- Eliciting parental support for the use of newborn blood spots for pediatric research
- A two-step approach for analysis of ignorable missing outcomes in longitudinal regression
- Examining the prevalence rates of preexisting maternal medical conditions and pregnancy complications by source: evidence to inform maternal and child research
Early Childhood Growth and Development
- Maternal pre-pregnancy obesity and achievement of infant motor developmental milestones in the Upstate KIDS Study
- Maternal medical conditions during pregnancy and children’s gross motor development up to age 24 months
- Gross motor milestones and subsequent development
- Parental Obesity and Early Childhood Development
- Prenatal Fish Oil Supplementation and Early Childhood Development
- Timing of Maternal Depression and Sex-specific Child Growth
- Breastfeeding and motor development among term and preterm infants in a longitudinal U.S. cohort
- Parental Health Status and Infant Outcomes, Upstate KIDS Study
- Maternal polycystic ovarian syndrome and early offspring development
- Maternal polycystic ovarian syndrome and offspring growth
- Association of Trajectory and Covariates of Children's Screen Media Time
- Developmental outcomes in small for gestational age twins using a singleton versus twin birthweight reference in Upstate KIDS
Fertility Treatment
- Conception by fertility treatment and offspring deoxyribonucleic acid methylation
- Infertility treatment and autism risk using the Modified Checklist for Autism in Toddlers (M-CHAT)
- Infertility treatment and children’s longitudinal growth between birth and 3 years of age
- Examining Infertility Treatment and Early Childhood Development
Other
- Perfluorooctanoic acid (PFOA) or perfluorooctane sulfonate (PFOS) and DNA methylation in newborn dried blood spots in the Upstate KIDS cohort
- Trajectories of maternal postpartum depressive symptoms
- Gestational age at birth and risk of developmental delay: The Upstate KIDS Study
- Parental weight status and offspring behavioral problems and psychiatric symptoms
- Prenatal and early life exposures to ambient air pollution and development
- Wheeze and food allergies in children born via cesarean delivery: The Upstate KIDS Study
- Examining endocrine disruptors measured in newborn dried blood spots and early childhood growth in a prospective cohort
- Differences in infant feeding practices by mode of conception in a United States cohort
- Predictors of Age at Juice Introduction and Associations with Subsequent Beverage Intake in Early and Middle Childhood