Brian A. Parr
Director, Mouse Transgenic Facility
Academic Background
- Ph.D., 1986, Cornell University, Ithaca, NY
Professional Background
- Director, University of Colorado Cancer Center Transgenic/Knockout Core facility, Denver, CO, 2004-2007
- Assistant Professor, University of Colorado, Boulder, CO, 1995-2003
- Postdoctoral fellow, Roche Institute of Molecular Biology and Harvard University, Cambridge, MA, 1990-1995
- Postdoctoral fellow, Indiana University, Bloomington, IN, 1986-1990
Honors and Awards
- Principal Investigator on 5 grants
- "Wnt Signalling in Reproductive Organs"; U.S. Patent 6,485,972; issued 11/26/02
- Mortar Board Honor Society Outstanding Professor, 2001
- Cornell University Graduate Fellowship, 1983-1984
- NSF Graduate Fellowship, 1982-1983
- Sage Graduate Fellowship, 1981-1982
Research Experience
- Analysis of Wnt gene function in mouse development
- Gene targeting of mouse Wnt7a and Wnt7b genes
- Analysis of T-box genes in mouse and frog development
- Transgenic mouse analysis of Wnt7b and Nestin promoters using lacZ reporters
- Mouse embryonic stem cell culture and gene targeting
- In situ hybridization analysis of gene expression
- Culture, transfection, and analysis of mammalian cell lines
Selected Publications
- Nunnally, A.P. and Parr, B.A. (2004). Analysis of frizzled10 expression in mouse embryos. Dev., Genes, & Evol. 214:144-148.
- Carson, C.T., Pagratis, M., and Parr, B.A. (2004). Tbx12 regulates eye development in Xenopus embryos. Biochem. Biophys. Res. Comm. 318:485-489.
- Brown, D.D., Binder, O., Pagratis, M., Parr, B.A., and Conlon, F.L. (2003). Developmental expression of the Xenopus Tbx20 orthologue. Dev., Genes, & Evol. 212: 604-607.
- Parr, B.A., Cornish, V.A., Cybulsky, M.I., and McMahon, A.P. (2001). Wnt7b regulates placental development in mice. Dev. Biol. 237:324-332.
- Carson, C.T., Kinzler, E.R., and Parr, B.A. (2000). Tbx12, a novel T box gene, is expressed during early stages of heart and retinal development. Mech. Dev. 96:137-140.
- Parr, B.A. and McMahon, A.P. (1998). Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a. Nature 395:707-710.
- Parr, B.A., Avery, E.J,, Cygan, J.A., and McMahon, A.P.(1998). The classical mouse mutant postaxial hemimelia results from a mutation in the Wnt-7a gene. Dev. Biol. 202:228-234.
- Klymkowsky, M.W. and Parr, B. (1995). The body language of cells: The intimate connection between cell adhesion and behavior. Cell 83:5-8.
- Parr, B. and McMahon, A. (1995). Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature 374:350-353.
- Parr, B., and McMahon A. (1994). Wnt genes and vertebrate development. Curr. Opin. Genet. Dev. 4:523-528.
- Zimmerman, L., Parr, B., Lendahl, U., Cunningham, M., McKay, R., Gavin, B., Mann, J., Vassileva, G., and McMahon, A. (1994). Identification of two distinct regulatory elements within the nestin gene that direct gene expression to mammalian neuronal stem cells or somites. Neuron 12:11-24.
- Parr, B., Shea, M., Vassileva, G., and McMahon, A. (1993). Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds. Development 119:247-261.