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- Begley, T.J., Haas, B.J., Morales, J.C., Kool, E.T., and Cunningham,
R.P. (2003) Kinetics and binding of the thymine-DNA mismatch glycosylase,
Mig-Mth, with mismatch-containing DNA substrates. DNA Repair 2, 107-120.
- Marenstein, D.R., Chan, M.K., Altamirano, A., Basu, A.K., Boorstein,
R.J., Cunningham, R. P., and Teebor, G.W. (2003) Substrate specificity
of human endonuclease III (hNth1): Effect of human AP endonuclease 1 (APE1)
on hNTh1 Activity. J. Biol. Chem. 278, 9005-9012.
- Burgis, N.E., Brucker, J, J. and Cunningham, R.P. (2003) A repair
system for non-canonical purines in Escherichia coli. J. Bacteriol.
185, 3101-3110.
- Ocampo, M.T.A., Chaung, W., Marenstein, D.R., Chan, M.K., Altamirano,
A., Basu, A.K., Boorstein, R.J., Cunningham, R.P., and Teebor, G.W. (2002)
Targeted deletion of mNth1 reveals a novel DNA repair enzyme
activity. Mol. Cell. Biol. 22, 6111-6121.
- Mol, C.D., Arvai A. S.,
Begley, T. J., Cunningham, R. P., and Tainer, J. A. (2002) Structure
and Activity of a Thermostable Thymine-DNA Glycosylase : Evidence for Base
Twisting to Remove Mismatched Normal DNA Bases. J. Mol. Biol. 315,373-384.
- Marenstein, D.R., Ocampo, M.T., Chan, M.K., Altamirano, A., Basu, A.K.,
Boorstein, R.J., Cunningham, R.P., and Teebor, G.W. (2001) Stimulation
of human endonuclease III by Y box-binding protein 1 (DNA-binding protein
B). Interaction between a base excision repair enzyme and a transcription
factor. J. Biol. Chem. 276,21242-21249.
- Hashimoto M, Greenberg MM, Kow YW, Hwang JT, Cunningham RP. (2001)
The 2-deoxyribonolactone lesion produced in DNA by neocarzinostatin and
other damaging agents forms cross-links with the base-excision repair enzyme
endonuclease III. J. Am. Chem. Soc. 123,3161-3162.
- Chheda A.D., Teebor G.W., and Cunningham, R.P. (2000) Identification,
characterization, and purification of DNA glycosylase/AP lyases by reductive
crosslinking to 2'-deoxyribooligonucleotides containing specific base lesions.
Methods 22,180-187.
- Milligan, J. R., Aguilera J. A., Nguyen, T\_T. D., Ward, J. F., Kow,
Y. W., He, B. and Cunningham, R. P. (1999) Yield of DNA Strand Breaks
after Base Oxidation of Plasmid DNA. Radiat. Res. 151, 334-342.
- Begley, T. J. and Cunningham R.P. (1999) Methanobacterium thermoformicicum
Thymine DNA mismatch glycosylase: conversion of an N-glycosylase to an AP
lyase. Protein Engineering,12, 333-340.
- Haas B.J., Sandigursky, M., Tainer, J.A., Franklin, W.A. and Cunningham,
R.P. (1999) Purification and characterization of Thermotoga maritima
endonuclease IV; a thermostable apurinic/apyrimidinic endonuclease and 3'-repair
diesterase. J. Bacteriol. 181, 2834-2839.
- Begley, T.J., Haas B.J., Noel, J., Shekhtman, A., Williams, W.A., and
Cunningham, R.P. (1999) A new member of the endonuclease III family
of DNA repair enzymes which removes methylated purines from DNA. Current
Biology 9, 653-656.
- Bazar, L.S., Collier, G.B., Vanek, P.G., Siles, B.A., Kow, Y.W., Doetsch,
P.W., Cunningham, R.P., and Chirikjian, J.G. (1999) Mutation identification
DNA analysis system (MIDAS) for detection of known mutations. Electrophoresis
6, 1141-1148.
- Shekhtman, A., McNaughton, L., Cunningham, R.P., and Baxter, S.M. (1999)
Identification of the Archaeoglobul fulgidus endonuclease III-DNA interaction
surface using heteronuclear NMR methods. Structure 7, 919-930.
- Hosfield, D.J., Guan, Y., Haas, B.J., Cunningham, R.P., and Tainer
J.A. (1999) Structure of the DNA repair enzyme endonuclease IV and its
complex with DNA: double-nucleotide flipping at abasic sites and three-metal-ion
catalysis. Cell 98, 397-408.
- Hilbert, T.P., Chaung, W., Boorstein, R.J., Cunningham, R.P., and Teebor,
G.W. (1997) Cloning and expression of the cDNA encoding the human homologue
of the DNA repair enzyme, Escherichia coli endonuclease III. J. Biol.
Chem. 272, 6733-6740.
- Jen, J., Mitchell, D.L., Cunningham, R.P., Smith, C.A., Taylor, J-S.,
and Cleaver, J.E. (1997) Ultraviolet irradiation produces novel endonuclease
III-sensitive cytosine photoproducts at dipyrimidine sites. Photobiol.
Photochem. 65, 323-329.
- Cunningham, R.P. (1997) DNA glycosylases. Mutat. Res. 383, 189-196.
- Cunningham, R.P. (1997) Caretakers of the genome? Curr. Biol.
7, 576-579.
- Hilbert, T.P., Boorstein, R.J., Xing, D., Kung, P.H., Bolton, P.H.,
Cunningham, R.P. and Teebor, G.W. (1996) Purification of a mammalian
homolog of E. coli endonuclease III: Identification of a calf thymus pyrimidine
hydrate/thymine glycol/AP lyase by crosslinking the enzyme to a thymine
glycol-containing DNA-oligonucleotide. Biochemistry 35,2505-2511.
- Cunningham, R.P. (1996) DNA repair: How yeast repair radical damage.
Curr. Biol. 6, 1230-1233.
- Purmal, A.A., Rabow, L..E, Lampman, G.W., Cunningham, R.P.and Kow Y.W.
(1996) A common mechanism of action for the N-glycosylase activity of
DNA N-glycosylase/AP lyases from E. coli and T4. Mutat. Res. 364,
193-207.
- Milligan J.R., Ng J.Y., Wu C.C., Aguilera J.A., Ward J.F., Kow Y.W.,
Wallace S.S. and Cunningham R.P. (1996) Methylperoxyl radicals as intermediates
in the damage to DNA irradiated in aqueous dimethyl sulfoxide with gamma
rays. Radiat. Res. 146, 436-443.
- O' Handley, S., Scholes, C.P., and Cunningham, R.P. (1995) Endonuclease
III interactions with DNA substrates: 1. Binding and footprinting studies
with oligonucleotides containing a reduced apyrimidinic site. Biochemistry
34,2528-2536.
- Xing, D. Dorr, R., Cunningham, R.P., and Scholes, C.P. (1995)
Endonuclease III interactions with DNA substrates: 2. The DNA repair enzyme
endonuclease III binds differently to intact and to AP DNA substrates as
shown by tryptophan fluorescence quenching. Biochemistry 34,2537-2544.
- Mol, C.D., Kuo, C-F., Thayer, MM, Cunningham, R.P. and Tainer, J.A.
(1995) Structure and function of the multifunctional DNA repair enzyme
exonuclease III. Nature 374,381-386
- Barzilay, G., Mol, C.D. Robson, C.N. Walker, L.J. Cunningham, R.P.,
Tainer, J.A., and Hickson, I.D. (1995) Identification of critical active-site
residues in the multifunctional human DNA repair enzyme HAP1. Nature
Structural Biology 2,561-568.
- Thayer, M.M., Ahern, H., Xing, D., Cunningham, R.P., and Tainer, J.A.
(1995) Novel DNA binding motifs in the DNA-repair enzyme endonuclease
III structure. EMBO J. 14,4108-4120.
- Zuo, S., Boorstein, R.J., Cunningham, R.P. and Teebor, G.W. (1995)
Comparison of the effects of UV irradiation on 5-methylsubstituted and unsubstituted
pyrimidines in alternating Py-Pu sequences in DNA. Biochemistry 34,11582-11590.
- O' Donnell, R.E., Boorstein, R.J., Cunningham, R.P., and Teebor, G.W.
(1994) Effect of pH and temperature on the stability of UV-induced repairable
pyrimidine hydrates in DNA. Biochemistry 33,9875-9880.
- Hatahet, Z., Kow, Y.W., Purmal, A.A., Cunningham, R.P., and Wallace,
S.S. (1994) New substrates for old enzymes: 5-hydroxy-2' -deoxycytidine
and 5-hydroxy-2' - deoxyuridine are substrates for Escherichia coli endonuclease
III and formamidopyrimidine DNA N-glycosylase while 5-hydroxy-2, -deoxyuridine
is a substrate for uracil DNA N-glycosylase. J.Biol.Chem. 269,18814-18820.
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