Dr. Tenniswood's Lab - Current Lab Members

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Martin Tenniswood, Ph.D.

Wei-Lin Winnie Wang

picture of Wei-Lin Winnie Wang

Winnie was born in Taipei, Taiwan but immigrated and lived in Canada after she finished junior high school in 1998. She majored in biochemistry during her undergraduate studies at Queen’s University in Kingston, Ontario, Canada. Through Queen´s co-op program, organized by Professor Albert Clark, Winnie had the opportunity to work in Dr. Tenniswood´s laboratory for two eight-month terms in 2005 and 2006 at the University of Notre Dame in South Bend, Indiana. During her internships, she focused her research on a marine macrolide, Iejimalide, particularly studying its effects in hormone responsive cancers, including prostate and breast cancers. After finishing her BSc degree in Queen´s University, she joined Dr. Tenniswood´s laboratory in the University at Albany where she is currently a doctoral student in the Department of Biomedical Sciences. Her current project investigates the crosstalk between vitamin D- and testosterone-mediated signaling in prostate cancer, using in vitro models. Winnie was awarded a three year pre-doctoral fellowship from the Congressionally Directed Medical Research Programs in Prostate Cancer that supports her research.

Publications

  • Wang, W.L.W., McHenry, P., Jeffrey, R., Schweitzer, D., Helquist, P. and Tenniswood, M. (2008)
    Effects of Iejimalide B, a Marine Macrolide, on Growth and Apoptosis in Prostate Cancer Cell Lines.
    Journal of Cellular Biochemistry 105: 998-1007.

  • McHenry, P., Wang, W.L.W., Devitt, E., Kluesner, N., Davisson, V.J., McKee, E., Schweitzer, D., Helquist, P and Tenniswood, M. (2010)
    Iejimalides A and B Inhibit Lysosomal Vacuolar H+-ATPase (V-ATPase) Activity and Induce S-phase Arrest and Apoptosis in MCF-7 Cells.
    Journal of Cellular Biochemistry 109:634-642.

  • Mordan-McCombs, S., Brown, T., Wang, W.L., Gaupel, A.C., Welsh, J., and Tenniswood, M. (2010)
    Tumor Progression in the LPB-Tag Transgenic Model of Prostate Cancer is Altered by Vitamin D Receptor and Serum Testosterone Status.
    Journal of Steroid Biochemistry and Molecular Biology,121:368-371.

  • Wang, W.L.W., Chatterjee, N., Chittur, S.V., Welsh, J. and Tenniswood, M.P. (2011)
    Effects of 1α,25 dihydroxyvitamin D3 and Testosterone on miRNA and mRNA Expression in LNCaP Cells.
    Molecular Cancer 10:58. doi:10.1186/1476-4598-10-58.

  • Knutson, A.K., Welsh, J., Taylor, T., Roy, S., Wang, W.L.W. and Tenniswood, M. (2012)
    Comparative Effects of Histone Deacetylase Inhibitors on p53 Target Gene Expression, Cell Cycle and Apoptosis in MCF-7 Breast Cancer Cells.
    Oncology Reports 27:849-853.

  • Wang, W.L.W., Welsh, J. and Tenniswood, M. (2012)
    1,25 dihydroxyvitamin D3 modulates lipid metabolism in prostate cancer cells through miRNA mediated regulation of PPARA.
    Journal of Steroid Biochemistry and Molecular Biology doi: 10.1016/j.jsbmb.2012.09.033.

  • Simmons K.M., Wang W.L.W., Tenniswood, M., and Welsh J. (2012)
    Vitamin D and Inflammation in Cancer: Emerging Concepts. In: Inflammation and Cancer: Mechanisms and Dietary Approaches for Cancer Prevention. Kong, A; Taylor and Francis (in press)

  • Gaupel A.-C., Wang, W.L.W., Mordan-McCombs, S., Lee, E.C.Y. and Tenniswood, M. (2012)
    Xenograft, Transgenic and Knockout Models of Prostate Cancer. In: Animal Models of Human Disease. Conn, M (ed) Elsevier (in press)

Namita Chatterjee

picture of Namita Chatterjee

Namita Chatterjee is a doctoral student in the Department of Biomedical Science. She is working in Dr. Martin Tenniswood´s laboratory at the Cancer Research Center located at the SUNY East Campus in Rensselaer, NY. Her studies focus on developing novel targeted therapies for a rare form of breast cancer, inflammatory breast cancer or IBC. Namita was born and raised in Dryden, Ontario, Canada. She received an honors B.Sc. co-op degree in Biology from the University of Waterloo in Waterloo, Ontario, Canada. Following her undergraduate studies, she earned an M.S degree in Biochemistry from the University of Notre Dame in Indiana in 2008. She has been a doctoral student since June 2008

Namita´s current research is focused on understanding the molecular biology of inflammatory breast cancer (a rare but lethal form of breast cancer). She is exploring the underlying biology of the effects of histone deacetylase inhibitors on cell lines developed from inflammatory breast cancer. She has completed the first genome wide comparison of the effects of two histone deacetylase inhibitors (CG-1521 and TSA) on both mRNA and miRNA expression, and the phenotypic consequences on mitotic processes. The inflammatory breast cancer cell lines she has used represent both triple negative and Her2 overexpressing tumor lines, and the genome wide expression analysis provides good evidence that histone deacetylase inhibitors will be useful additions to the armamentarium for treatment of inflammatory breast cancer as mono- or combination therapies

Publications

  • Flanagan, L., Whyte, L., Chatterjee, N., and Tenniswood, M. (2010)
    Effects of Clusterin Over Expression on Metastatic Progression and Therapy in Breast Cancer.
    BMC Cancer 10:107. doi:10.1186/1471-2407-10-107.

  • Wang, W.L.W., Chatterjee, N., Chittur, S.V., Welsh, J. and Tenniswood, M.P. (2011)
    Effects of 1α,25 dihydroxyvitamin D3 and Testosterone on miRNA and mRNA Expression in LNCaP Cells.
    Molecular Cancer 10:58. doi:10.1186/1476-4598-10-58.

  • Chatterjee, N., Wang, W.L.W., Conklin, T. Chittur, S.V. and Tenniswood, M.P. (2013)
    Histone Deacetylase Inhibitors Modulate miRNA and mRNA Expression, Block Metaphase and Induce Apoptosis in Inflammatory Breast Cancer Cells.
    Breast Cancer Research (submitted)

Ann-Christin Gaupel

picture of Ann-Christin Gaupel

Ann-Christin first worked in the Tenniswood laboratory in the Department of Biological Sciences at the University of Notre Dame, South Bend, Indiana as part of a co-op program with the University of Bielefeld in Germany in 2007. Her internship was supported by an award from the Integrated Studies Abroad Program funded by the Deutscher Akademischer Austauchdienst. During her first co-op term Ann-Christin participated in a project designed to evaluate the role of the vitamin D receptor (VDR) in tumor progression in a mouse model of prostate cancer. She rejoined the laboratory after it moved to the University at Albany Cancer Research Center, and completed the research portion of her Diplom in Biochemistry Biochemistry (the equivalent to an MS), co-supervised by Prof. Dr. Gabriele Fischer von Mollard. When she came back to the laboratory for her second extended rotation (from June 2008 to March 2009), she used 2D gel electrophoresis and mass spectrometry to characterize the post-translational modifications (acetylation and phosphorylation) of p53 induced by histone deacetylase inhibitors in LNCaP prostate cancer cells.

Her doctoral research, which she started in August 2009, is designed to elucidate the mechanism of action of Type I histone deacetylase inhibitors using a whole genome yeast deletion library screen to determine which gene deletions confer sensitivity and resistance to histone deacetylase inhibitors. This work is being carried out in collaboration with Dr. Tom Begley, in the NanoBioscience Constellation in the College of Nanoscale Science and Engineering. The aim of the project is to improve therapeutics for breast and prostate cancer by identify critical transcription factors that are targets for histone deacetylases inhibitors.

Publications

  • Mordan-McCombs, S., Brown, T., Wang, W.L., Gaupel, A.C., Welsh, J., and Tenniswood, M. (2010)
    Tumor Progression in the LPB-Tag Transgenic Model of Prostate Cancer is Altered by Vitamin D Receptor and Serum Testosterone Status. Journal of Steroid
    Biochemistry and Molecular Biology 121: 368-371.

  • Gaupel A.-C., Wang, W.L.W., Mordan-McCombs, S., Lee, E.C.Y. and Tenniswood, M. (2012)
    Xenograft, Transgenic and Knockout Models of Prostate Cancer. In: Animal Models of Human Disease. Conn, M (ed) Elsevier (in press)