Zhimin (Tim) Cao
Postdoctoral, Clinical Chemistry & Toxicology, University of Louisville School of Medicine, Louisville, KY
Ph.D., University of Manitoba School of Medicine, Winnipeg, Canada
MD., Harbin Medical University, China (1984)
Director, Clinical Chemistry Laboratory & Endocrinology Section, Clinical Laboratory Reference System, Wadsworth Center, New York State Department of Health
Development and validation of liquid chromatography-mass spectrometry (LC-MS/MS)-based assays/methods have been a part of research activities within the Clinical Chemistry Laboratory. Outcomes of such activities, some were done in collaboration with colleagues at CDC and the Department of Psychology at the University at Albany have led to many articles published in peer-reviewed scientific journals in the areas mainly including (1) analytical accuracy and precision assessment of FDA-approved methods and Laboratory-Developed Tests for patient testing, (2) clinical laboratory quality performance evaluation via accuracy-based proficiency testing or external quality assessment, (3) identification of quality issues in analytical & post-analytical phases, (4) salivary hormone tests using LC-MS/MS methods and (5) addictive behaviors/alcohol abuse associated psychological research, where noninvasive detection of hormones is needed. My past research experience and interests included protein purification and characterization, gene mutation identification, production of mutant proteins via site-directed mutagenesis, and analysis of the impact of a gene mutation on the protein expression levels, structure, stability and functional properties.
Learn more about Dr. Cao's work:
- Publications (Partial list)
Cao (T)Z, Botelho JC, Rej R, Vesper H, Astles RJ. Impact of testosterone measurement standardization efforts assessed by accuracy-based proficiency testing. Clin Biochem. 2019 Mar 28. pii: S0009-9120(19)30088-8. doi: 10.1016/j.clinbiochem.2019.03.014
Cao Z(T), Wemm S, Wulfert E. Noninvasive determination of human cortisol and dehydroepiandrosterone sulfate using liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem 2019:411(6):1203-10. https://doi.org/10.1007/s00216-018-1549-x
Han L, Tavakoli NP, Morrissey M, Spink D. Cao (T)Z. Liquid chromatography-tandem mass spectrometry analysis of 17-hydroxyprogesterone in dried blood spots revealed matrix effect on immunoassay. Anal Bioanal Chem 2019;411:395-402. DOI: 10.1007/s00216-018-1449-0.
Wemm SE, Cao Z, Han L, Wulfert E. Stress responding and stress-related changes in cue reactivity in heavy smokers, problem gamblers, and healthy controls. Addiction Biology 1 Oct 2018. DOI: 10.1111/adb.12687.
Cao Z, Swift TA, West CA, Rosano TG, Rej R. Immunoassay of estradiol: unanticipated suppression by unconjugated estriol. Clinical Chemistry. 2004;50(1):160-165.
Cao Z, Petroulakis E, Salo T, Triggs-Raine B. Benign HEXA mutations, C739T(R247W) and C745T(R249W), cause beta-hexosaminidase A pseudodeficiency by reducing the alpha-subunit protein levels. Journal of Biological Chemistry. 1997;272(23):14975-1498.