Roxana Moslehi

Roxana Moslehi, PhD

Cancer researcher an expert on genetic epidemiology, cancer susceptibility, DNA repair genes.

The World Within Reach
Roxana Moslehi, PhD
Associate Professor

School of Public Health
Department: Epidemiology and Biostatistics

Genetic Epidemiologist
Cancer Research Center
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Postdoctoral Fellowship [Genetic Epidemiology and Biostatistics], Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), NIH

Ph.D. [Medical Genetics], University of British Columbia (UBC), Vancouver, BC

M.Sc. [Medical Genetics], University of British Columbia (UBC), Vancouver,BC

B.Sc.(Honours) [Cell & Developmental Biology], UBC, Vancouver, BC

Research Interests

The overall objectives of my research studies are to identify genetic and environmental determinants of complex disorders and to quantify their effects. I have expertise in designing family-based and population-based genetic epidemiologic investigations and in statistical analysis of genetic and epidemiologic data. As part of my studies, I have also conducted genetic counseling for hereditary cancer susceptibility. The methodologies currently employed in my laboratory include family studies, case-control studies, analysis of genome-wide association studies (GWAS), candidate-gene and whole-genome linkage analyses, and gene expression (gene chip) array and transcriptome analyses. Various malignant and pre-malignant conditions have been the focus of my research. I have been studying cancer risks associated with mutations in the DNA repair genes for a number of years. Based on recent clinical observations, I also initiated several studies to gain insight into the biologic mechanisms which underlie the association between DNA repair and transcription gene abnormalities in the fetus and increased risk of gestational complications.

Additional Information

Courses Taught:

“Cancer Epidemiology” (EPI 604)
“Genetic Epidemiology” (EPI 624)
“Masters Seminars in Epidemiology” (EPI 602)
“Principles and Methods of Epidemiology II” (EPI 502)
"Principles and Methods of Epidemiology I" (EPI 501)
"Basic Principles and Methods of Epidemiology" (EPI 500)
“Molecular Epidemiology” (EPI 512)
"Introduction to Genetic Epidemiology” (EPI 512)


  • Moslehi R, Zeinomar N, Boscoe FP. Incidence of Cutaneous Malignant Melanoma in IranianProvinces and American States Matched on Ultraviolet Radiation Exposure: AnEcologic Study. Environmental Pollution 2018; 234:699-706
  • Kempin S, Finger P, Gale RP, Rescigno J, Rubin J, Choi W, Roberts E, Fisher R, Aizman A, Genis I, Malamud S, and Moslehi R. A Cluster of Vitreoretinal Lymphoma in New York with Possible Link to the Chernobyl Nuclear Disaster.  Leukemia & Lymphoma 2017; Nov. 22: 1-4 
  • Moslehi R, Freedman E, Zeinomar N, Veneroso C, and Levine PH. Importance of Hereditary and Selected Environmental Risk Factors in the Etiology of Inflammatory Breast Cancer: A Case-Comparison Study. BMC Cancer 2016; 16:334      
  • Moslehi R, Ambroggio X, Nagarajan V, Kumar A, and Dzutsev A. Nucleotide Excision Repair/Transcription Gene Defects in the Fetus and Impaired TFIIH-Mediated Function in Transcription in Placenta Leading to Preeclampsia. BMC Genomics 2014; 15:373
  • Moslehi R, Mills JL, Signore C, Kumar A, Ambroggio X and Dzutsev A. Integrative Transcriptome Analysis Reveals Dysregulation of Canonical Cancer Molecular Pathways in Placenta Leading to Preeclampsia. Scientific Reports 2013; 3: 2407
  • Zeinomar N and Moslehi R. The Effectiveness of a Community-Based Breast Cancer Education Intervention in the New York State Capital Region. Journal of Cancer Education 2013; 28:466-473
  • Chen L, Bell EM, Browne M, Druschel C, Romitti P, Schmidt R, Burns T, Moslehi R, Olney RS and the National Birth Defects Prevention Study. Maternal Caffeine Consumption and Risk of Congenital Limb Deficiencies. Birth Defects Research Part A: Clinical and Molecular Teratology 2012; 94 (12):1033-43
  • Moslehi R, Kumar A, Mills JL, Ambroggio X, Signore C and Dzutsev A. Phenotype-Specific Adverse Effects of XPD Mutations on Human Prenatal Development Implicate Impairment of TFIIH-Mediated Functions in Placenta. European Journal of Human Genetics 2012; 20: 626-631
  • Tamura D, Merideth M, DiGiovanna J, Zhou X, Tucker M, Goldstein A, Brooks B, Khan S, Oh K-S, Ueda T, Boyle J, Moslehi R* and Kraemer K*. High-Risk Pregnancy and Neonatal Complications in the DNA Repair and Transcription Disorder Trichothiodystrophy: Report of 27 Affected Pregnancies. Prenatal Diagnosis 2011; 31(11): 1046-1053
  • Moslehi R, Schymura MJ, Nayak S and Coles FB. Ocular Adnexal Non-Hodgkin Lymphoma: A Review of Epidemiology and Risk Factors. Expert Review of Ophthalmology 2011; 6(2): 181-193
  • Moslehi R, Coles FB, Schymura MJ. Descriptive Epidemiology of Ophthalmic and Ocular Adnexal Non-Hodgkin Lymphoma. Expert Review of Ophthalmology 2011; 6(2): 175-180
  • Moslehi R, Signore C, Tamura D, Mills J, DiGiovanna J, Tucker M, Troendle J, Ueda T, Boyle J, Khan S, Oh K-S, Goldstein A, Kraemer K. Adverse Effects of Trichothiodystrophy DNA Repair and Transcription Gene Disorder on Human Fetal Development. Clinical Genetics 2010; 77(4): 365-373
  • Moslehi R, Singh R, Lessner L, Friedman JM. Impact of BRCA Mutations on Female Fertility and Offspring Sex Ratio. American Journal of Human Biology 2010; 22(2): 201-205
  • Kuznetsov IB*, McDuffie M, and Moslehi R*. Application of supervised pattern recognition to infer N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype. Bioinformatics 2009; 25(9):1185-1186
  • Tan X, Moslehi R, Han W, and Spivack S. Haplotype tagging single nucleotide polymorphisms in the glutathione S-transferase P1 gene promoter and susceptibility to lung cancer. Cancer Detection and Prevention 2009; 32(5-6):403-415