Martin Tenniswood

Martin P. R. Tenniswood

Specializes in development, progression, and treatment of prostate and breast cancers.

The World Within Reach
Martin P. R. Tenniswood
Empire Innovation Professor

School of Public Health
Department: Biomedical Sciences

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PhD, Queen's University, Kingston, ON (1979)
Post-doctoral National Institute for Medical Research, Mill Hill, UK (1980-1983)


Manuscripts in Peer-Reviewed Journals (Since 2007)

  • Mordan-McComb S., Brown T. Welsh J. and Tenniswood M. (2007) Dietary Calcium Does Not Affect Prostate Tumor Progression in LPB-Tag Transgenic Mice. Journal of Steroid Biochemistry and Molecular Biology. 103:747-751
  • Roy S., and Tenniswood M. (2007) Site Specific Acetylation of p53 Directs Selective Transcription Complex Assembly. Journal of Biological Chemistry 282: 4765-4771.
  • Suckow, M., Rosen, E., Wolter, W.R., Sailes, V., Jeffrey R., and Tenniswood, M. (2007) Prevention of human PC-346C prostate cancer growth in mice by xenogeneic tissue vaccine. Cancer Immunology and Immunotherapeutics 56:1275-1283.
  • Morrissey, C., Brown, M., O´Sullivan J., Weathered, N., Watson, R., and Tenniswood, M. (2007) Epigallocatechin-3-Gallate and Bicalutamide Cause Growth Arrest and Apoptosis in NRP-152 and NRP-154 Prostate Epithelial Cells. International Journal of Urology 282:4765-4771.
  • Mordan-McCombs, S., Valrance, M., Zinser, G., Tenniswood, M., Welsh, J. (2007) Calcium, Vitamin D and the Vitamin D Receptor in Pre-Clinical Models. Nutrition Reviews 65:S131-S133.
  • Roy, S. Jeffrey R. and Tenniswood, M. (2008) Array Based Analysis of the Effects of Trichostatin A and CG-1521 on Cell Cycle and Cell Death in LNCaP Prostate Cancer Cells. Molecular Cancer Therapeutics 7:1931-1939.
  • O´Sullivan, J., Sheridan J., Mulcahy H., Tenniswood M., and Morrissey C. (2008) The Effect of Green Tea on Oxidative Damage and Tumour Formation in Lobund-Wistar Rats. European Journal of Cancer Prevention 17:489-501.
  • Wang, W.L.W., McHenry, P., Jeffrey, R., Schweitzer, D., Helquist, P. and Tenniswood, M. (2008) Effects of Iejimalide B, a Marine Macrolide, on Growth and Apoptosis in Prostate Cancer Cell Lines. Journal of Cellular Biochemistry 105: 998-1007.
  • Kevans, D., Foley, J., Tenniswood, M., Sheahan, K., Hyland, J., O'Donoghue, D., Mulcahy, H., and O'Sullivan, J. (2009) High clusterin expression correlates with a poor outcome in stage II colorectal cancers. Cancer Epidemiology, Biomarkers and Prevention 18:393-399.
  • McHenry, P., Wang, W.L.W., Devitt, E., Kluesner, N., Davisson, V.J., McKee, E., Schweitzer, D., Helquist, P and Tenniswood, M.(2010) Iejimalides A and B Inhibit Lysosomal Vacuolar H+-ATPase (V-ATPase) Activity and Induce S-phase Arrest and Apoptosis in MCF-7 Cells. Journal of Cellular Biochemistry 109:634-642.
  • Flanagan, L., Whyte, L., Chatterjee, N., and Tenniswood, M.(2010) Effects of Clusterin Over-Expression on Metastatic Progression and Therapy in Breast Cancer. BMC Cancer 10:107. doi:10.1186/1471-2407-10-107
  • Mordan-McCombs, S., Brown, T., Wang, W.L., Gaupel, A.C., Welsh, J., and Tenniswood, M. (2010) Tumor Progression in the LPB-Tag Transgenic Model of Prostate Cancer is Altered by Vitamin D Receptor and Serum Testosterone Status. Journal of Steroid Biochemistry and Molecular Biology,121:368-371.
  • Wang, W.L.W., Chatterjee, N., Chittur, S.V., Welsh, J. and Tenniswood, M.P. (2011) Effects of 1α,25 dihydroxyvitamin D3 and Testosterone on miRNA and mRNA Expression in LNCaP Cells. Molecular Cancer 10:58. doi:10.1186/1476-4598-10-58.
  • Whitcomb, J.P., DeAgostino, M., Ballentine, M., Fu, J., Tenniswood, M., Welsh, J., Cantorna, M., and McDowell, M.A. (2011) The Role of Vitamin D and Vitamin D Receptor in Immunity to Leishmania major Infection. Journal of Parasitology Research 2012:134645.
  • Knutson, A.K., Welsh, J., Taylor, T., Roy, S., Wang, W.L.W. and Tenniswood, M. (2012) Comparative Effects of Histone Deacetylase Inhibitors on p53 Target Gene Expression, Cell Cycle and Apoptosis in MCF-7 Breast Cancer Cells. Oncology Reports 27:849-853.
  • Wang, W.L.W., Welsh, J. and Tenniswood, M. (2012) 1,25 dihydroxyvitamin D3 modulates lipid metabolism in prostate cancer cells through miRNA mediated regulation of PPARA. Journal of Steroid Biochemistry and Molecular Biology doi: 10.1016/j.jsbmb.2012.09.033.


  • Simmons K.M., Wang W.L.W., Tenniswood, M., and Welsh J. (2012) Vitamin D and Inflammation in Cancer: Emerging Concepts. In: Inflammation and Cancer: Mechanisms and Dietary Approaches for Cancer Prevention. Kong, A; Taylor and Francis (in press)
  • Gaupel A.-C., Wang, W.L.W., Mordan-McCombs, S., Lee, E.C.Y. and Tenniswood, M. (2012) Xenograft, Transgenic and Knockout Models of Prostate Cancer. In: Animal Models of Human Disease. Conn, M (ed) Elsevier (in press)