Ramune Reliene, Ph.D.

Academic Appointment Title:
Assistant Professor in the Department of Environmental Health Sciences

Center Affiliation:
Faculty member at the Cancer Research Center

Contact Information:
1 Discovery Dr., Rm. 304
Cancer Research Center
School of Public Health
University at Albany, State University of New York
Rensselaer, NY 12144

Phone Number: (518) - 591-7152     
Fax Number: (518) -  591-7201
Email Address:  rreliene@albany.edu 

Post-doctoral fellowship in Carcinogenesis
University of California Los Angeles 2001 - 2005

Ph.D. in Biochemistry
Swiss Federal Institute of Technology (ETH) 1998 - 2001

M.S. in Biochemistry
University of Vilnius 1994-1996

B.S. in Biochemistry
University of Vilnius 1990-1994

Courses Frequently Taught:
EHS 530 Principals of Toxicology
EHS 535 Environment and Cancer
EHS 590 Introduction to Environmental Health
BMS 601 Biomedical Science Horizons

Research Interests:
The focus of the lab is on translational cancer research on gene-environment and gene-nutrient interactions. We investigate whether mutations in DNA repair genes enhance susceptible to cancer associated with environmental causes and whether the risk of cancer can be reduced with intake of dietary antioxidants. For example, we are currently exploring the concept that antioxidant-rich pomegranate extract protects against breast cancer. Other projects include studies on genotoxic and cancer risks of engineered nanoparticles used in consumer products. We use genomic technologies in combination with cell and molecular biology and whole animal approaches to dissect the complexity of cancer.

Select Publications:
Shirode A.B., Coon J.K., Nallanthighal S., Bharali D.J., Mousa S.A, and Reliene R. (2015) Nanoencapsulation of pomegranate bioactive compounds for breast cancer chemoprevention” International Journal of Nanomedicine 10:475-84.                                                                                          http://www.ncbi.nlm.nih.gov/pubmed/25624761

Kovvuru P., Mancilla P.E., Shirode A.B., Murray T.M., Begley T.J. and Reliene R. (2014) “Oral ingestion of silver nanoparticles induces genomic instability and DNA damage in multiple tissues”. Nanotoxicology. Epub ahead of print.                                                                                             http://www.ncbi.nlm.nih.gov/pubmed/24713076

Shirode A.B., Kovvuru P., Chittur S.V., Henning S.M., Heber D. and Reliene R. (2014) “Antiproliferative effects of pomegranate extract in MCF-7 breast cancer cells are associated with reduced DNA repair gene expression and induction of double strand breaks”. Molecular Carcinogenesis 53:458-470.                                                                         http://www.ncbi.nlm.nih.gov/pubmed/23359482

Reliene R., Yamamoto M.L., Rao P.N., and Schiestl R.H. (2010) “Genomic instability in mice is greater in Fanconi anemia caused by deficiency of Fancd2 than Fancg”. Cancer Research 70: 9703-9710.                                                                                                                                       http://www.ncbi.nlm.nih.gov/pubmed/21118969

Trouiller B., Reliene R., Westbrook A., Solaimani P., and Schiestl R.H. ( 2009) “Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice”. Cancer Research 69: 8784-8789.                                                                                                                             http://www.ncbi.nlm.nih.gov/pubmed/19887611

Reliene R., Fleming S.M, Chesselet M-F, and Schiestl R. H. (2008) “Effects of antioxidants on cancer prevention and neuromotor performance in Atm deficient mice”. Food and Chemical Toxicology 46:1371-1377.                                                                                                                    http://www.ncbi.nlm.nih.gov/pubmed/18037553