J. Andres Melendez

J. Andres Melendez

Interim Dean of the College of Nanoscale Science and Engineering, SUNY Poly
The RNA Institute

Contact

NFE 4313 SUNY Poly
Education
  • Post Doctoral Fellow, Department of Biochemistry, Albany Medical College, 1997
  • Post Doctoral Associate, Division of Lung Biology, Georgetown University Medical Center, 1995 
  • PhD, Biological Sciences, with a concentration in Molecular Biology, University at Albany, State University of New York, 1992
J. Andres Melendez
About

Areas of Research

  • Free Radical Biology
  • Cellular and organismal aging biology
  • Matrix Remodeling
  • Nanobiotechnology
  • Host & Pathogen interactions 

Research Description

Our studies revolve around a key central paradigm, that oxidant signaling is precise, compartmentalized and amenable to targeted‐antioxidant based therapies. Reactive oxygen and nitrogen species (ROS/RNS), in addition to their ability to damage biomolecules, have also emerged as key mediators in regulation of signaling networks by modulating phosphatase activity, kinase cascades and transcription factor binding. Thus, ROS/RNS serve a dual role, at low concentrations they are secondary signaling molecules that regulate the expression of a wide array of signaling networks, and at high concentrations damage lipids, protein and DNA. The principle mediator of ROS‐dependent signaling is the 2e‐ reduction product of oxygen, H2O2, which is produced in response to numerous physiologic stimuli. Recent work from my lab and others indicate that superoxide (O2‐•) may also play an important role in cellular signal regulation.

Our work is focused on defining how ROS/RNS drive cellular signaling events that control cellular senescence, metastatic disease, matrix destruction and the virulence of infectious bacteria. We have developed many cutting-edge tools to monitor oxidant production from cells in real time. Our studies indicate that that augmented free radical production initiate or drive age-associated disease. CNSE is unique and provides the scientific infrastructure for the development of innovative therapeutic and diagnostic technologies to limit degenerative disease.