Ing-Nang Wang

  • Ing-Nang Wang


    Dr. Wang‘s laboratory focuses on the host-range evolution of viruses. Specifically, the group uses bacteria and bacteriophages as the model systems to investigate how interactions between ecological conditions and viral traits facilitate the evolution of a generalist or specialist pathogen. Mostly, Escherichia coli and related bacteria are used as hosts, and phage  and single-stranded RNA phages as the viral pathogens. The laboratory uses a combination of genetic, genomic, and experimental evolution approaches. The group has successfully conducted a serial transfer experiment with an IncHI-plasmid-dependent ssRNA phage, Hgal1, being passaged in multiple bacterial species within the Enterobacteriaceae family. Whole-genome sequencing of the evolved viral strains showed some mutations to be common to all viral strains evolved in different bacterial species, while others are unique to evolution in individual hosts. The main focus for subsequent investigations will be to elucidate, from the perspective of viral trait evolution, the interactions between evolved viral RNA genomes and viral proteins and host factors.