Oct. 20, 2017
Wei's manuscript on the effects of the R/G editing of GluA2Rflop in GluA1/2R heteromeric channels (Nature Scientific Reports) is now online.
Sept. 21, 2017
Group gathering at 11:30 am.
Sept. 5, 2017
The article for the FN1040, a 2′-fluoro modified aptamer that inhibits glutamate receptors, is now online at ACS Chem Neurosci.
July 31, 2017
Ph.D. candidate Andrew Wu′s thesis defense.
Location: Life Science Building 2094
The Niu research group is multidisciplinary, combining chemistry, electrophysiology, and molecular biology to solve significant problems in human health. The Niu group is addressing problems associated with drug discovery for targeting glutamate ion channel proteins. These channel proteins are indispensable to brain activities such as learning and memory, and malfunction of these proteins has been implicated in neurological diseases such as ALS, stroke, epilepsy and neuropathic pain. We are working on project areas with broader impact potential, such as structure-function relationship of glutamate ion channels and drug discovery, by developing RNA aptamers and small-molecule regulatory agents (i.e., both positive and negative regulators) as potential drug candidates. RNA hydrogel becomes our latest project stemmed from our discovery that an RNA aptamer discovered in our group is capable of self-assembling into RNA hydrogel!