SILVANA C. NGO
silvana_ngo@hotmail.com

RESEARCH AREAS:

• Inorganic/organometallic
  • Design, synthesis and characterization of novel Group IV transition metal complexes for olefin polymerization
  • Preparation of novel precursors for MOCVD (copper, silver β-diketonates, dialkyldithiocarbamates)
  • Synthesis and characterization of novel paramagnetic transition metal complexes
  • X-ray crystallography
• Organic chemistry
  • Synthesis of silyl compounds (fluorinated acylsilanes, diketones)
  • Studies on superacid-catalyzed aromatic chemistry
  • Studies on metal-mediated organic transformations
  • Direct fluorination
• Molecular biology/Biochemistry
  • Preparation of genetically engineered polypeptides for molecular interconnect applications (cloning, protein purification and characterization)
  • Isolation and purification of M. tuberculosis fatty acid synthetase I from M. smegmatis
  • Enzyme kinetics

PATENTS:

• Silver Precursors for CVD Processes
  Welch, J. T.; Ngo, S. C.; Banger, K. K. US Patent Number 6 613 924, Sept 2, 2003.
• MOCVD Precursors based on Organometalloid Ligands
  Welch, J. T.; Banger, K. K.; Higashiya, S.; Ngo, S. C. US Patent Number 6 340 768, Jan 22, 2002.
• Metal Triflimide Complexes
  Welch, J. T.; Claessen, R.; Ngo, S. C. US Patent Number 5 986 120, Nov 16, 1999; WO 9940124, Aug 1999; EP 1053259, Nov 2000.

• Improved and facile addition reactions of pentafluorosulfanyl bromide
  Lim, D. S.; Ngo, S. C.; Lal, S. G.; Minnich, K. E.; Welch, J. T. Tetrahedron Lett. 2008, 49, 5662-3.
• Inhibition of isolated Mycobacterium tuberculosis fatty acid synthase I by pyrazinamide analogs
  Ngo, S. C.; Zimhony, O.; Chung, W. J.; Sayahi, H.; Jacobs, W. R. Jr.; Welch, J. T. Antimicrobial Agents and Chemotherapy 2007, 51, 2430-5.
• Design and preparation of β-sheet forming repetitive and block-copolymerized polypeptides
  Higashiya, S.; Topilina, N. I.; Ngo, S. C.; Zagorevskii, D.; Welch, J. T. Biomacromolecules 2007, 8, 1487-1497.
• Synthesis and utility of fluorinated acylsilanes
  Welch, J. T.; Chung, W. J.; Higashiya, S.; Ngo, S. C.; Lim, D. S. ACS Symposium Series (2005), 911(Fluorine-Containing Synthons), 378-398.
• Bilayer Fibril Formation by Genetically Engineered Polypeptides: Preparation and Characterization
  Topilina, N. I.; Higashiya, S.; Rana, N.; Ermolenkov, V.; Kossow, C.; Carlsen, A.; Ngo, S. C.; Wells, C. C.; Eisenbraun, E. T.; Dunn, K. A.; Lednev, I. K.; Geer, R. E.; Kaloyeros, A. E.; Welch, J. T. Biomacromolecules 2006, 7, 1104-11.
• Synthesis of Mono- and Difluoroacetyltrialkylsilanes and the Corresponding Enol Silyl Ethers
  Higashiya, S.; Chung, W. J.; Lim, D. S.; Ngo, S. C.; Kelly, W. H.; Toscano, P. J.; Welch, J. T. J. Org. Chem. 2004, 69, 6323-8.
• Lewis Acid Promoted Aldol Reaction of Fluorinated Silyl Enol Ethers from New Fluoroacetylsilane Derivatives
  Chung, W. J.; Ngo, S. C.; Higashiya, S.; Welch, J. T. Tetrahedron Lett. 2004, 45, 5403-6.
• Metallization of Polypeptide Arrays for Molecular Interconnect Applications
  Carlsen, A.; Ngo, S. C.; Higashiya, S.; Kossow, C.; Topilina, N. I.; Wells, C. C.; Cheng, D.; Ermolenkov, V.; Raynolds, J.; Dunn, K.; Eisenbraun, E. T.; Kaloyeros, A. E.; Lednev, I.; Geer, R. E.; Welch, J. T. Polymeric Materials: Science and Engineering 2004, 91, 474.
• Investigations Into the Preparation of Sila-β-diketones via 2-Trimethylsilyl-1,3-dithianes: Structural Characterization of a Second Polymorph of Bis(2,2,6,6-tetramethyl-2-sila-3,5-heptanedionato)copper(II)
  Claessen, R. U.; Kornilov, A. M.; Banger, K. K.; Ngo, S. C.; Higashiya, S.; Wells, C. C.; Dikarev, E. V.; Toscano, P. J.; Welch, J. T. J. Organomet. Chem. 2004, 689, 71-81.
• Preparation and Characterization of Repetitive Polypeptides for Molecular Interconnect Applications
  Higashiya, S.; Ngo, S. C.; Bousman, K. S.; Welch, J. T.; Rana, N.; Carlsen, A.; Eisenbraun, E. T.; Geer, R. E.; Kaloyeros, A. E. Polymeric Materials: Science and Engineering 2003, 89, 466-7.
• Structural Investigations of Copper(II) Complexes Containing Fluorine-substituted β-Diketonate Ligands
  DelaRosa, M. J.; Banger,K. K.; Higashiya, S.; Ngo, S. C.; Hunt, D. H.; Bousman, K. S.; Toscano, P. J.; Welch, J. T. J. Fluorine Chem. 2003, 123, 109-17.
• Synthesis of Fluorinated α-Sila-β-diketones and Their Cu(II) Complexes
  Higashiya, S.; Banger, K. K.; Ngo, S. C.; Lim, P.; Toscano, P. J.; Welch, J. T. Inorganica Chimica Acta 2003, 351, 291-304.
• Facile Synthesis of a Novel Class of Organometalloid-Containing Ligands, the Sila-β-diketones: Preparation and Physical and Structural Characterization of the Copper(II) Complexes, [Cu(R^'(CO)CH(CO)SiR₃)₂]
  Banger, K. K.; Ngo, S. C.; Higashiya, S.; Claessen, R. U.; Bousman, K. S.; Lim, P. N.; Toscano, P. J.; Welch, J. T. J. Organomet. Chem. 2003, 678, 15-32.
• Thermal and Structural Characterization of a Series of Homoleptic Copper(II) Dialkyldithiocarbamate Complexes: Bigger is Only marginally Better for Potential MOCVD Performance
  Ngo, S. C.; Banger, K. K.; DelaRosa, M. J.; Toscano, P. J.; Welch, J. T. Polyhedron 2003, 22(12), 1575-83.
• Efficient Biological Construction of Repetitive Polypeptides for Interconnect Applications by Block Copolymerization
  Higashiya, S.; Ngo, S. C.; Bousman, K. K.; Jin, X.; Welch, J. T.; Eisenbraun, E. T.; Geer, R. E.; Kaloyeros, A. E. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 2003, 44(1), 679-680.
• Preparation and Characterization of Half-Sandwich Pentamethylcyclopentadienyl Titanium(IV) Triflate Complexes: Solid-State Structural Motifs and Catalysis Studies
  Ngo, S. C.; Toscano, P. J.; Welch, J. T. Helv. Chim. Acta 2002, 85(10), 3366-82.
• Synthesis and Physical and Structural Characterization of Ag(I) Complexes Supported by Non-fluorinated β-Diketonate and Related Ancillary Ligands
  Ngo, S. C.; Banger, K. K.; Toscano, P. J.; Welch, J. T. Polyhedron 2002, 21, 1289-97.
• Reactions of Novel Mono- and Difluoroacetyltrialkylsilanes with Sulfur and Phosphorus Ylides
  Ngo, S. C.; Chung, W. J.; Lim, D. S.; Higashiya, S.; Welch, J. T., J. Fluorine Chem. 2002, 117(2), 207-211.
• Bistriflate Titanium Complexes for the Polymerization of Styrene
  Ngo, S. C.; Okuda, J.; Toscano, P. J.; Welch, J. T. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 1996, 37(2), 331-2.
• Ring-Opening Polymerization of Lactones by Mono(cyclopentadienyl)titanium Complexes
  Okuda, J.; Kleinhenn, T.; Koenig, P.; Taden, I.; Ngo, S.; Rushkin, I. L. Macromol. Symp. 1995, 95 (Synthesis of Controlled Polymeric Structures Through Living Polymerization and Related Processes), 195-202.
• Ring-Opening Polymerization of Lactones by Mono(cyclopentadienyl)titanium Complexes
  Okuda, J.; Koenig, P.; Ngo, S.; Rushkin, I. L. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 1994, 35(2), 524-5.
• Pseudo Interpenetrating Polymer Networks of Crystalline Polystyrene
  Du, Y.; Xu, Q.; Xue, Y.; Ngo, S.; Okuda, J.; Frisch, H.L. Macromolecules 1994, 27, 2757-60.

PRESENTATIONS: (presenter in italics)

• Inhibition of M. tuberculosis Fatty Acid Synthetase I Isolated from M. smegmatis by 5-Cl-Pyrazinamide and Analogs
  Ngo, S. C.; Zimhony, O.; Sayahi, H.; Jacobs, W. R. Jr.; Welch, J. T. 229th National Meeting of the American Chemical Society, San Diego, CA, Mar 13-17, 2005.
• Biotemplate Directed Growth of Metallic Nanowires
  Carlsen, A.; Rana, N.; Ngo, S. C.; Kossow, C.; Higashiya, S.; Topilina, N. I.; Zhu, Y.; Ermolenkov, V.; Wells, C. C.; Raynolds, J.; Dunn, K.; Eisenbraun, E. T.; Lednev, I.; Geer, R. E.; Welch, J. T.; Kaloyeros, A. E. 2005 Materials Research Society Spring Meeting, San Francisco, CA, Symposium AA8.10, Mar 28-Apr 1, 2005.
• Inhibition of M. tuberculosis Fatty Acid Synthetase I Isolated from M. smegmatis by 5-Cl-Pyrazinamide and Analogss
  Ngo, S. C.; Chung, W. J.; Zimhony, O.; Jacobs, W. R. Jr.; Welch, J. T. 44th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, D.C., Oct 30-Nov 2, 2004.
• Metallization of Polypeptide Arrays for Molecular Interconnect Applications
  Carlsen, A.; Ngo, S. C.; Higashiya, S.; Kossow, C.; Topilina, N. I.; Wells, C. C.; Cheng, D.; Ermolenkov, V.; Raynolds, J.; Dunn, K.; Eisenbraun, E. T.; Kaloyeros, A. E.; Lednev, I.; Geer, R. E.; Welch, J. T. 228th National Meeting of the American Chemical Society, Philadelphia, PA, Aug 22-26, 2004.
• Design and Synthesis of Bioengineered Self-assembling Repetitive Polypeptides for Molecular Device Assembly
  Higashiya, S.; Ngo, S. C.; Bousman, K. S.; Wells, C. C.; Welch, J. T.; Rana, N.; Carlsen, A.; Kossow, C.; Eisenbraun, E. T.; Geer, R. E.; Kaloyeros, A. E. 2004 Materials Research Society Spring Meeting, San Francisco, CA, Symposium V3.3, Apr 12-16, 2004.
• Self-Assembly of Genetically-Engineered Polypeptides for Nanowire Applications
  Kossow, C.; Rana, N.; Carlsen, A.; Higashiya, S.; Ngo, S.; Geer, R. E.; Welch, J.; Eisenbraun, E.; Kaloyeros, A. 2004 Materials Research Society Spring Meeting, San Francisco, CA, Symposium M10.6, Apr 12-16, 2004.
• Atomic-Force Microscopic Investigations of Genetically-Engineered Polypeptide Molecules for Interconnect Applications
  Rana, N.; Carlsen, A.; Kossow, C.; Mandal, S.; Higashiya, S.; Ngo, S.; Bousman, K.; Geer, R. E.; Eisenbraun, E. T.; Welch, J.; Kaloyeros, A. E. 2003 Materials Research Society Fall Meeting, San Franciscos, CA, Symposium O7.3, Dec 1-5, 2003.
• Preparation and Characterization of Repetitive Polypeptides for Molecular Interconnect Applications
  Higashiya, S.; Ngo, S. C.; Bousman, K. S.; Welch, J. T.; Rana, N.; Carlsen, A.; Eisenbraun, E. T.; Geer, R. E.; Kaloyeros, A. E. 226th National Meeting of the American Chemical Society, New York, NY, Sept 7-11, 2003.
• The Synthesis of Genetically Engineered Molecular Interconnect Candidates for use in Microelectronics
  Higashiya, S.; Ngo, S. C.; Bousman, K. S.; Jin, X.; Rana, N.; Eisenbraun, E. T.; Geer, R. E.; Kaloyeros, A. E.; Welch, J. T. 2003 Materials Research Society Spring Meeting, San Francisco, CA, Symposium O2.4, Apr 21-25, 2003.
• Investigations of the Self Organization of Genetically-Engineered Molecular Interconnects
  Rana, N.; Bousman, K.; Higashiya, S.; Ngo, S.; Welch, J.; Geer, R. E.; Eisenbraun, E. T.; Kaloyeros, A. E. 2003 Materials Research Society Spring Meeting, San Francisco, CA, Symposium K4.4, Apr 21-25, 2003.
• Efficient Biological Construction of Repetitive Polypeptides for Interconnect Applications by Block Copolymerization
  Higashiya, S.; Ngo, S. C.; Bousman, K. S.; Jin, X.; Welch, J. T.; Eisenbraun, E. T.; Geer, R. E.; Kaloyeros, A. E. 225th National Meeting of the American Chemical Society, New Orleans, LA, March 23-27, 2003.
• Reactions of Novel Mono- and Difluoroacetyltrialkylsilanes with Sulfur and Phosphorus Ylides
  Chung, W. J.; Ngo, S. C.; Lim, D. S.; Higashiya, S., Welch, J. T.224th National Meeting of the American Chemical Society, Boston, MA, August 18-22, 2002.
• Physical and Structural Characterization of New Homoleptic Copper(II) Dialkyldithiocarbamate Complexes
  Toscano, P. J.; Ngo, S. C.; Banger, K. K.; Dela Rosa, M. J.; Welch, J. T. 224th National Meeting of the American Chemical Society, Boston, MA, August 18-22, 2002.
• Physical and Structural Characterization of Metal Complexes of Silylated β-Diketonate Ligands Containing Fluorinated Substituents
  Toscano, P. J.; Higashiya, S.; Ngo, S. C.; Banger, K. K.; Lim, P.; Bousman, K. S. 222nd National Meeting of the American Chemical Society, Chicago, IL, August 26-30, 2001.
• Synthesis of Mono- and Difluoroacetyltrialkylsilanes and the Corresponding Silyl Enol Ethers: Novel and Versatile Synthons
  Higashiya, S.; Lim, D. S.; Ngo, S. C.; Toscano, P. J.; Welch, J. T. 222nd National Meeting of the American Chemical Society, Chicago, IL, August 26-30, 2001.
• A New Halogen-Free Organometallic Family of Precursors for CVD Copper Seed Layers: Design, Characterization and Process Development
  Claessen, R. U. ; Banger, K. K.; Ngo, S. C.; Higashiya, S.; Kornilov, A. M.; Lim, P.; Eisenbraun, E. T.; Toscano, P. J.; Kaloyeros, A. E.; Welch, J. T. 2001 Mechanics and Materials Conference, San Diego, CA, June 27-29, 2001.
• Silver Complexes for MOCVD
  Ngo, S. C.; Welch, J. T.; Banger, K. K.; Toscano, P. J.; Kaloyeros, A. E. 219th National Meeting of the American Chemical Society, San Francisco, CA, March 26-30, 2000.
• Precursor Engineering and Characterization of New Volatile Copper MOCVD Precursors for Thin-Film Deposition
  Welch, J. T.; Banger, K. K.; Ngo, S. C.; Claessen, R. U.; Toscano, P. J.; Eisenbraun, E. T.; Kaloyeros, A. E. 219th National Meeting of the American Chemical Society, San Francisco, CA, March 26-30, 2000.
• Preparation and Structural Characterization of New Transition Metal Complexes Containing Triflate and Triflimide Ligands
  Welch, J. T.; Ngo, S. C.; Claessen, R.; Banger, K. K.; Toscano, P. J. 12th European Symposium on Fluorine Chemistry, Berlin, Germany, August 29-September 2, 1998.
• Synthesis, Structural Characterization and Polymerization Activity of Group IV Bistrifluoromethanesulfonimide Complexes
  Toscano, P. J.; Ngo, S. C.; Claessen, R.; Banger, K. K.; Welch, J. T. 216th National Meeting of the American Chemical Society, Boston, MA, August 23-27, 1998.
• Titanium Complexes for the Polymerization of Styrene
  Ngo, S. C.; Toscano, P. J.; Welch, J. T. 215th National Meeting of the American Chemical Society, Dallas, TX, March 29-April 2, 1998.
• Bistriflate Titanium Complexes for the Polymerization of Styrene
  Ngo, S. C.; Okuda, J.; Toscano, P. J.; Welch, J. T. 212th National Meeting of the American Chemical Society, Orlando, FL, August 25-29, 1996.
• Ring-Opening Polymerization of Lactones by Mono(cyclopentadienyl)titanium Complexes
  Okuda, J.; Konig, P.; Ngo, S.; Rushkin, I. L. 208th National Meeting of the American Chemical Society, Washington, DC, August 21-25, 1994.
• Mono(cyclopentadienyl)titanium Complexes as Initiators for the Living Ring-Opening Polymerization of ε-Caprolactone
  Okuda, J.; Ngo, S.; Rushkin, I. L. 206th National Meeting of the American Chemical Society, Chicago, IL, August 22-27, 1993.