Richard P. Cunningham

Professor of Biology

Office: BI232

Phone: (518) 442-4331

Email: [email protected]

Fax: (518) 442-4767

Research Interests:

Biochemistry of DNA Repair Enzymes
DNA Repair in Bacteria
Structure and Function of DNA Lyases [Click here to view endonuclease III bound to DNA]
Structure and function of DNA Nucleases [Click here to view exonuclease III bound to DNA]
Structure and Function of DNA Glycosylases
Genetic Analysis of DNA Repair Pathways

Recent Publications:

Kuo,C-H., Thayer, M.M., Mol, C.D., Cunningham, R.P., and Tainer, J.A. (1994) Structure and function of the DNA repair enzyme exonuclease III from E. coli. Annals of the New York Academy of Science 726, 223-235.
O' Donnell, R.E., Boorstein, R.J., Cunningham,R.P., and Teebor, G.W. (1994) Effect of pH and temperature on the stability of UV-induced repairable pyrimidine hydrates in DNA. Biochemistry 33,9875-9880.
Cunningham, R.P., M.M. Thayer and Tainer, J.A. (1994) Structure of the DNA repair enzyme endonuclease III. Nucleic Acids and Molecular Biology 8, 227-235.
Hatahet, Z., Kow, Y.W., Purmal, A.A., Cunningham, R.P., and Wallace, S.S. (1994) New substrates for old enzymes: 5-hydroxy-2' -deoxycytidine and 5-hydroxy-2' - deoxyuridine are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase while 5-hydroxy-2, -deoxyuridine is a substrate for uracil DNA N-glycosylase. J.Biol.Chem. 269,18814-18820.
O' Handley, S., Scholes, C.P., and Cunningham, R.P. (1995) Endonuclease III interactions with DNA substrates: 1. Binding and footprinting studies with oligonucleotides containing a reduced apyrimidinic site. Biochemistry 34,2528-2536. Click here to see abstract.
Xing, D. Dorr, R., Cunningham, R.P., and Scholes, C.P. (1995) Endonuclease III interactions with DNA substrates: 2. The DNA repair enzyme endonuclease III binds differently to intact and to AP DNA substrates as shown by tryptophan fluorescence quenching. Biochemistry 34,2537-2544. Click here to see abstract.
Tainer, J.A., Thayer, M.M. and Cunningham, R.P. (1995) DNA repair proteins. Curr. Opin. Struct. Biol. 5,20-26.
Mol, C.D., Kuo, C-F., Thayer, MM, Cunningham, R.P. and Tainer, J.A. (1995) Structure and function of the multifunctional DNA repair enzyme exonuclease III. Nature 374,381-386. Click here to see abstract.
Barzilay, G., Mol, C.D. Robson, C.N. Walker, L.J. Cunningham, R.P., Tainer, J.A., and Hickson, I.D. (1995) Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1. Nature Structural Biology 2,561-568. Click here to see abstract.
Thayer, M.M., Ahern, H., Xing, D., Cunningham, R.P., and Tainer, J.A. (1995) Novel DNA binding motifs in the DNA-repair enzyme endonuclease III structure. EMBO J. 14,4108-4120. Click here to see abstract.
Zuo, S., Boorstein, R.J., Cunningham, R.P. and Teebor, G.W. (1995) Comparison of the effects of UV irradiation on 5-methylsubstituted and unsubstituted pyrimidines in alternating Py-Pu sequences in DNA. Biochemistry 34,11582-11590.
Hilbert, T.P., Boorstein, R.J., Xing, D., Kung, P.H., Bolton, P.H., Cunningham, R.P. and Teebor, G.W. (1996) Purification of a mammalian homolog of E. coli endonuclease III: Identification of a calf thymus pyrimidine hydrate/thymine glycol/AP lyase by crosslinking the enzyme to a thymine glycol-containing DNA-oligonucleotide. Biochemistry 35,2505-2511.


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