Undergraduate Research Opportunities in Structural Biology

Sheng Lab

Lab Website

Our lab is interested in the structural and functional studies of naturally occurring modifications in nucleic acid, the most important biological macromolecules. The diversified chemical modifications discovered in DNA and RNA (including tRNA, mRNA, rRNA and all the other non-coding RNAs) play critical biological roles and are directly related to many diseases. We hope the atomic-level understanding of their 3D structures and their metabolic pathways will lead to better elucidation of their functions and shed light on the potential drug discovery based on them. In addition, these modifications are the most evolutionarily conserved properties in the early stage of cellular life, providing important clues to study the prebiotic chemistry and the origin of life.

Fabris Laboratory

Lab Website

Research interests: Using mass spectroscopy to investigate macromolecular complexes, protein-nucleic acid interactions in viruses, high-resolution mass spectrometry, and RNA-based drug therapeutics.

The Li Lab

Lab Website

Our goal is to understand the fundamental principles that governing the folding of RNA and to protein-RNA interactions.

Chen Lab

Lab Website

Our research focuses on the use of physics-based simulations of RNA as a tool for studying RNA folding and biomolecular engineering.

The Agris Laboratory

Lab Website

Research interests: Structure/function relationships of nucleic acids, RNA-targeted drug discovery, Novel RNA-based antimicrobial targets, Roles of modified nucleosides in tRNA, Nuclear magnetic resonance (NMR) of RNA, RNA-RNA and RNA-protein interactions

Shekhtman Lab

Lab Website

Research interests: Structural studies of protein-protein interactions involved in cellular signal transduction, structural studies of endocytic proteins and their interactions, development of novel NMR methodologies to effectively study large bio-complexes