Undergraduate Research Opportunities in Immunology

Multiplex Biotechnology Laboratory

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Our group is focused on development of multiplex biotechnologies based on nanotechnology and microfluidics, particularly barcode arrays, for disease diagnostics and forensic investigation. This unique lab also aims to apply the multiplex tools and employ principles in systems biology and physics to tackle the major challenges in immunology and cancer therapeutics, and to offer new perspectives of multi-scale biosystem development.

Canki Lab

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Our laboratory focuses on translational research of HIV-1 pathogenesis and mechanisms of virus inhibition by novel class of natural small molecules. We investigated a large number of natural products, and from Sargassum fusiforme we isolated and identified several new inhibitors that block virus during different stages of its replication life cycle. Palmitic acid, which binds to the CD4 receptor and blocks gp120-to-CD4 fusion and HIV-1 entry and infection, is being investigated in preclinical studies towards a microbicide application. Several other molecules are being studied to determine their activity and mechanisms of action.

De Jesus Lab

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The focus of the De Jesus laboratory is to understand the early events of how antigens (micro and nanoparticle delivery vehicles) and microbes (fungi such as Candida albicans and Candida tropicalis) are sampled by the intestinal mucosa. We are particularly interested in the how immune system cells within intestinal Peyer’s patches (PPs) capture, process and yield a specific immune response to these antigens and microbes. We have recently identified a specific dendritic cell (DCs) subset called Langerin+ DCs within Peyer’s patches that can capture a variety of micro and nanoparticles, fungi, algae and peanut antigens. Our aim is to understand why these DCs can sample such a variety of antigens and microbes and how do these contribute to intestinal immunity.

Lee Lab

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The laboratory engages in basic research designed to better understand and modulate immunological memory or general host defense. The two main projects we study are 1) the CD4 T lymphocyte which directs both cellular and humoral (antibody-mediated) immune responses. Stimulation of CD4 T cells and promoting their differentiation is a key element that underlies vaccination. 2) Bat immunity. Bats are currently the subject of intense interest due to their decimation by the disease White Nose Syndrome. Projects employ animal models and tissue culture, cellular immunology, flow cytometry, and immunochemical techniques to study immune cell development, activation, regulation, and function.

Harton Lab

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Similar to Toll-like receptors (TLR), proteins of the NLR family serve as intracellular pathogen sensors and regulators of immune responses. Invading bacteria such as those causing the plague, tularemia, and food poisoning are detected by NLRs. Some NLRs normally drive inflammatory responses when macrophages are infected by activating transcription factors such as NF-kB and MAPK as well as inducing production of inflammatory proteins like IL-1. They can also promote programmed cell death to help limit infection. Mutations within select NLRs are involved in a number of inflammatory diseases including Crohn’s Disease and Muckle-Wells Syndrome. One project currently seeks to understand NLR regulation. A second project considers a large protein, CIITA. Unlike other NLRs, CIITA is a transcription factor controlling expression of Major Histocompatibility Class (MHC) II genes. MHC II is absolutely critical to the normal functioning of both cellular and humoral immunity. Understandably, CIITA plays a role in multiple disease states ranging from arthritis and immunodeficiency to AIDS and cancer. Utilizing a wide array of molecular, cellular, biochemical, and animal based approaches we are advancing our understanding of the underlying molecular basis for how these proteins work in both health and disease. Previous students (depending on the project and the student’s skills/interest) have performed bioinformatics, cell culture, cloning, eukaryotic cell transfection, flow cytometry, gene expression assays, immunofluorescence microscopy, PCR, protein assays, and tumor growth/rejection studies. Undergraduate researchers will have the opportunity to interact with technical staff as well as postdoctoral and graduate students.