Undergraduate Research Opportunities in Bioorganic Chemistry

Sheng Lab

Lab Website

Our lab is interested in the structural and functional studies of naturally occurring modifications in nucleic acid, the most important biological macromolecules. The diversified chemical modifications discovered in DNA and RNA (including tRNA, mRNA, rRNA and all the other non-coding RNAs) play critical biological roles and are directly related to many diseases. We hope the atomic-level understanding of their 3D structures and their metabolic pathways will lead to better elucidation of their functions and shed light on the potential drug discovery based on them. In addition, these modifications are the most evolutionarily conserved properties in the early stage of cellular life, providing important clues to study the prebiotic chemistry and the origin of life.