Please click a link below to find out more about students currently in the BMS department. Current students, please click the "Useful Student Resources" link for University at Albany and BMS Department resources.
Featured Student Profiles
MPH Internship Commentaries
New Faces of BMS
Useful Student Resources
Featured Student Profiles
Elisabeth Knoll - Matthew A. Florczyk Award Recipient
Ms. Elisabeth (Lis) Knoll is this year’s recipient of the Matthew A. Florczyk Memorial Award. Lis, a 4th year Biomedical Science Ph.D. student in Dr. Randy Morse’s lab, is studying the Mediator complex in yeast. During her tenure as a graduate student Lis has dealt with obstacles many students do not have to face. First, her initial Ph.D. project got “scooped”, forcing her to regroup and start a new project. Second, she faced funding uncertainties, which even resulted in her working without a stipend for part of one summer. Despite these challenges, Lis has remained dedicated to her research, found time to serve on the BMS/EHS Graduate Student Organization and the local chapter of the American Society for Microbiology, and participated in many local community fundraising events. Her dedication to research and service to others despite professional adversity make Lis ideally suited for this award. Congratulations Lis!
Matt Florczyk was a former University at Albany Biomedical Sciences student who lived courageously and inspired many of the individuals around him until his untimely death in January 2009. Matt was a leader in his BMS class, and was widely known for his generous nature, commitment to community, and exceptional work ethic. He received his PhD from the BMS Department in 2000, based on his dissertation work on 'Interactions between Mycobacterium tuberculosis and its host cell macrophage'.
Matt distinguished himself early on in his graduate career as a pioneer who was passionate about mastering new techniques and fearless about taking on the most difficult challenges. He became an expert in electron microscopy, proteomics, molecular genetics and biosafety level three laboratory practice during his graduate work on M. tuberculosis pathogenesis. Matt then made several significant new contributions to the TB field during his time as a postdoc at the Wadsworth Center, before attending Albany Medical College for his MD. Despite his heavy workload, and the significant health-related challenges he faced throughout his career, Matt always had time for others and contributed countless volunteer hours for causes inside and outside of the Wadsworth Center. Matt moved on to a residency in internal medicine at Montefiore Medical Center upon receiving his MD in 2007, and dreamed of returning to his chosen home in Albany as a physician-scientist withhis own laboratory and clinical practice upon completion of his residency training.
Virginia Chu - Boren Fellowship Recipient
Virginia Chu, a 2nd year Biomedical Science PhD student in Dr. Jan Conn’s lab, has been awarded a National Security Education Program (NSEP) Boren Fellowship for 2015-2016. As a Boren Fellow, she will take language courses in Portuguese and spend seven months in São Paulo, Brazil. In addition to language instruction, she will continue her dissertation research on life history traits and population genetics of the malaria vector Anopheles darlingi at the Universidade de São Paulo with Dr. Maria Anice Sallum.
The David L. Boren Scholarships and Fellowships are sponsored by NSEP, a major federal initiative designed to build a broader and more qualified pool of U.S. citizens with foreign language and international skills. This year, the Institute of International Education, which administers the awards on behalf of NSEP, received 385 applications from graduate students and 101 Boren Fellowships were awarded. Since 1994, over 5,400 students have received Boren Awards, representing a vital pool of highly motivated individuals who wish to work in the federal national security arena.
William Lainhart is a doctoral candidate in Dr. Jan Conn's lab (Griffin Labs), a lab that studies the population genetics of Anopheles mosquitoes (vectors of malaria) in Central and South America. William is a third year PhD student in the BDEID fellowship track.
William's doctoral dissertation project is focused on the effects of landscape on neotropical vectors of malaria in Panamá, Perú and Brazil. Over this summer, William traveled to both Perú and Panamá to work with collaborating researchers. In Perú, William worked with Dr. Marta Moreno, a former post-doc in Dr. Conn's lab, and researchers at the Peruvian NGO PRISMA. During his three-week trip, William participated in laboratory work, field collections, study design and data analysis on Dr. Conn's International Centers for Excellence in Malaria Research (ICEMR) grant.
While in Panamá, William worked with Dr. José Loaiza (INDICASAT-AIP), a former student of Dr. Conn. William stayed in Panamá City for five weeks and conducted laboratory work at the Smithsonian Tropical Research Institute. During this time, he screened nearly 3,500 Anopheles mosquitoes, collected throughout Panama, for infection with Plasmodium.
Devon has recently been awarded the 2013 National Science Foundation Graduate Research Fellowship! Devon was chosen as one of the recipients of this fellowship out of 13,000 submitted applications from across the country. This fellowship will provide Devon with stipend and tuition support for 3 years and the opportunity for international research and professional development (3 – 12 months) at a NSF accredited institution. Devon submitted her application, which included a short research proposal, a personal statement and her research history, this past November.
Devon is a member of Dr. Joe Wade’s laboratory, studying non-canonical binding sites for transcription factors in Escherichia coli, to determine if they are functionally important and how they are acting to regulate transcription. These non-canonical binding sites are very common and are found within genes or downstream of genes, and are not associated with any known promoter.
For more information on the NSF Graduate Research Fellowship and how to apply, visit the fellowship program website.
Student Publications (last 2 years)
Ranganathan S, Bai G, Lyubetskaya A, Knapp GS, Peterson MW, Gazdik M, Gomes AL, Galagan JE, McDonough KA. 2015. Characterization of a cAMP responsive transcription factor, Cmr (Rv1675c), in TB complex mycobacteria reveals overlap with the DosR (DevR) dormancy regulon. Nucleic Acids Res.
Herrera C, Tremblay JM, Shoemaker CB, Mantis NJ. 2015. Mechanisms of Ricin Toxin Neutralization Revealed through Engineered Homodimeric and Heterodimeric Camelid Antibodies. J Biol Chem. 290: 27880-27889.
Lainhart W, Bickersmith SA, Nadler KJ, Moreno M, Saavedra MP, Chu VM, Ribolla PE, Vinetz JM, Conn JE. 2015. Evidence for temporal population replacement and the signature of ecological adaptation in a major Neotropical malaria vector in Amazonian Peru. Malar J. 14: 375.
Topilina NI, Green CM, Jayachandran P, Kelley DS, Stranger MJ, Piazza CL, Nayak S, Belfort M.2015. SufB intein of Mycobacterium tuberculosis as a sensor for oxidative and nitrosative stresses. PNAS. 112 (33) : 10348-53.
Levinson KJ, Giffen SR, Pauly MH, Kim DH, Bohorov O, Bohorova N, Whaley KJ, Zeitlin L, Mantis NJ. 2015. Plant-based production of two chimeric monoclonal IgG antibodies directed against immunodominant epitopes of Vibrio cholerae lipopolysaccharide. J Immunol Methods. 422: 111-117.
Levinson KJ, De Jesus M, Mantis NJ. 2015. Rapid Effects of a Protective O-Polysaccharide-Specific Monoclonal IgA on Vibrio choleraeAgglutination, Motility, and Surface Morphology. Infect. Immun. 83(4): 1674-1683.
Lainhart W, Bickersmith SA, Moreno M, Tong Rios C, Vinetz JM and JE Conn. 2015. Changes in genetic diversity from field to laboratory during colonization of Anopheles darlingi Root (Diptera:Culicidae). Am J Trop Med Hyg. doi: 10.4269/ajtmh.15-0336
Bickersmith SA, Lainhart W, Moreno M, Chu VM, Vinetz JM and JE Conn. 2015. A sensitive, specific and reproductible real-time polymerase chain reaction method for detection of Plasmodium vivax andPlasmodium falciparum infection in field-collected anophelines. Mem Inst Oswaldo Cruz 110(4): 573-576.
Qu G, Dong X, Piazza CL, Chalamcharla VR, Lutz S, Curcio MJ and M Belfort. 2014. RNA-RNA interactions and pre-mRNA mislocalization as drivers of group II intron loss from nuclear genomes. Proc Natl Acad Sci U S A. 111(18):6612-7.
Narvaez CJ, Matthews D, LaPorta E, Simmons KM, Beaudin S and J Welsh. 2014. The impact of vitamin D in breast cancer: genomics, pathways, metabolism. Front Physiol. 5:213.
Beaudin SG, Robilotto S and J Welsh. 2014. Comparative regulation of gene expression by 1,25-dihydroxyvitamin D3 in cells derived from normal mammary tissue and breast cancer. J Steroid Biochem Mol Biol. pii: S0960-0760(14)00213-1.
Keith ME, LaPorta E and J Welsh. 2014. Stable expression of human VDR in murine VDR-null cells recapitulates vitamin D mediated anti-cancer signaling. Mol Carcinog. 53(4):286-99.
LaPorta E and J Welsh. 2014. Modeling vitamin D actions in triple negative/basal-like breast cancer. J Steroid Biochem Mol Biol. 144 Pt A:65-73.
Rhieu SY, Annalora AJ, LaPorta E, Welsh J, Itoh T, Yamamoto K, Sakaki T, Chen TC, Uskokovic MR and GS Reddy. 2014. Potent antiproliferative effects of 25-hydroxy-16-ene-23-yne-vitamin D₃ that resists the catalytic activity of both CYP27B1 and CYP24A1. J Cell Biochem. 115(8):1392-402.
Wang WL and M Tenniswood. 2014. Vitamin D, intermediary metabolism and prostate cancer tumor progression. Front Physiol. 5:183.
Gaupel AC, Begley T and M Tenniswood. 2014. High throughput screening identifies modulators of histone deacetylase inhibitors. BMC Genomics. 15:528.
O'Hara JM, Kasten-Jolly JC, Reynolds CE and NJ Mantis. 2014. Localization of non-linear neutralizing B cell epitopes on ricin toxin's enzymatic subunit (RTA). Immunol Lett. 158(1-2):7-13.
Yermakova A, Klokk TI, Cole R, Sandvig K and NJ Mantis. 2014. Antibody-mediated inhibition of ricin toxin retrograde transport. MBio. 5(2):e00995.
Rudolph MJ, Vance DJ, Cheung J, Franklin MC, Burshteyn F, Cassidy MS, Gary EN, Herrera C, Shoemaker CB and NJ Mantis. 2014. Crystal structures of ricin toxin's enzymatic subunit (RTA) in complex with neutralizing and non-neutralizing single-chain antibodies. J Mol Biol. 426(17):3057-68.
Herrera C, Vance DJ, Eisele LE, Shoemaker CB and NJ Mantis. 2014. Differential neutralizing activities of a single domain camelid antibody (VHH) specific for ricin toxin's binding subunit (RTB). PLoS One. 9(6):e99788
Mukherjee P, Wilson RC, Lahiri I and JD Pata. 2014. Three residues of the interdomain linker determine the conformation and single-base deletion fidelity of Y-family translesion polymerases. J Biol Chem. 289(10):6323-31
Ansari SA, Paul E, Sommer S, Lieleg C, He Q, Daly AZ, Rode KA, Barber WT, Ellis LC, LaPorta E, Orzechowski AM, Taylor E, Reeb T, Wong J, Korber P and RH Morse. 2014. Mediator, TATA-binding protein, and RNA polymerase II contribute to low histone occupancy at active gene promoters in yeast. J Biol Chem. 289(21):14981-95.
Singh SS, Singh N, Bonocora RP, Fitzgerald DM, Wade JT and DC Grainger. 2014. Widespread suppression of intragenic transcription initiation by H-NS. Genes Dev. 28(3):214-9.
Fitzgerald DM, Bonocora RP and JT Wade. 2014. Comprehensive Mapping of the Escherichia coli Flagellar Regulatory Network. PLoS Genet. 10(10):e1004649.
Gridley CL, Rangarajan S, Firbank S, Dalal S, Sweasy JB and J Jaeger. 2013. Structural changes in the hydrophobic hinge region adversely affect the activity and fidelity of the I260Q mutator DNA polymerase β. Biochemistry. 52(25):4422-32.
O'Hara JM, Brey RN 3rd and NJ Mantis. 2013. Comparative efficacy of two leading candidate ricin toxin a subunit vaccines in mice. Clin Vaccine Immunol. 20(6):789-94.
Thomas JC, O'Hara JM, Hu L, Gao FP, Joshi SB, Volkin DB, Brey RN, Fang J, Karanicolas J, Mantis NJ and CR Middaugh. 2013. Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen. Hum Vaccin Immunother.9(4):744-52.
Hassett KJ, Cousins MC, Rabia LA, Chadwick CM, O'Hara JM, Nandi P, Brey RN, Mantis NJ, Carpenter JF and TW Randolph. 2013. Stabilization of a recombinant ricin toxin A subunit vaccine through lyophilization. Eur J Pharm Biopharm. 85(2):279-86.
Yermakova A and NJ Mantis. 2013. Neutralizing activity and protective immunity to ricin toxin conferred by B subunit (RTB)-specific Fab fragments. Toxicon. 72:29-34.
O'Hara JM and NJ Mantis. 2013. Neutralizing monoclonal antibodies against ricin's enzymatic subunit interfere with protein disulfide isomerase-mediated reduction of ricin holotoxin in vitro. J Immunol Methods. 395(1-2):71-8.
Greene CJ, Chadwick CM, Mandell LM, Hu JC, O'Hara JM, Brey RN 3rd, Mantis NJ and TD Connell. 2013. LT-IIb(T13I), a non-toxic type II heat-labile enterotoxin, augments the capacity of a ricin toxin subunit vaccine to evoke neutralizing antibodies and protective immunity. PLoS One. 8(8):e69678.
Wang WL, Welsh J and M Tenniswood. 2013. 1,25-Dihydroxyvitamin D3 modulates lipid metabolism in prostate cancer cells through miRNA mediated regulation of PPARA. J Steroid Biochem Mol Biol. 136:247-51.
Chatterjee N, Wang WL, Conklin T, Chittur S and M Tenniswood. 2013. Histone deacetylase inhibitors modulate miRNA and mRNA expression, block metaphase, and induce apoptosis in inflammatory breast cancer cells. Cancer Biol Ther. 14(7):658-71.
Baumann J, Sevinsky C and DS Conklin. 2013. Lipid biology of breast cancer. Biochim Biophys Acta. 1831(10):1509-17.
Jones DD, Jones M, DeIulio GA, Racine R, MacNamara KC and GM Winslow. 2013. B cell activating factor inhibition impairs bacterial immunity by reducing T cell-independent IgM secretion. Infect Immun. 81(12):4490-7.
Gray TA, Krywy JA, Harold J, Palumbo MJ and KM Derbyshire. 2013. Distributive conjugal transfer in mycobacteria generates progeny with meiotic-like genome-wide mosaicism, allowing mapping of a mating identity locus. PLoS Biol. 11(7):e1001602.
Mukherjee P, Lahiri I and JD Pata. 2013. Human polymerase kappa uses a template-slippage deletion mechanism, but can realign the slipped strands to favour base substitution mutations over deletions. Nucleic Acids Research.
Buitrago LS, Brochero HL, McKeon SN, Lainhart W and JE Conn. 2013. First published record of urban malaria in Puerto Gaitán, Meta, Colombia. Memórias do Instituto Oswaldo Cruz.
McKeon SN, Schlichting CD, Povoa MM and JE Conn. 2013. Ecological suitability and spatial distribution of five Anopheles species in Amazonian Brazil. Am J Trop Med Hyg 88(6): 1079-1086.
Lahiri I, Mukherjee P and J Pata. 2013. Kinetic characterization of exonuclease-deficientStaphylococcus aureus PolC, a C-family replicative DNA polymerase. PLoS ONE 8(5): e63489.
Bonocora RP, Fitzgerald DM, Stringer AM and JT Wade. 2013. Non-canonical protein-DNA interactions identified by ChIP are not artifacts. BMC Genomics 14: 254.
MPH Internship Commentaries
Internship Title: Idiopathic Pulmonary Fibrosis (IPF): A comprehensive evaluation of disease pathophysiology, biomedical research, and clinical observation
Internship Mentor: R. Matthew Kottmann, MD, University of Rochester
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disorder of the lungs that is characterized by the proliferation of interstitial fibroblasts and deposition of extracellular matrix. IPF is a serious and ultimately fatal disease with most patients living only 3-5 years after their diagnosis. The pathogenesis of IPF is variable and depends on certain individual factors such as genetic predisposition and environmental exposures. However, certain molecular drivers have been identified in disease pathogenesis. At this time there are limited therapeutic agents available for treating this devastating disease and there is no cure. This internship took place under the guidance of Dr. Kottmann, a pulmonologist and researcher at the University of Rochester. Dr. Kottmann is currently investigating the molecular mechanisms involved in the activation of the TGF-β (transforming growth factor) pathway. TGF-β is a cytokine responsible for inducing the differentiation of fibroblasts to myofibroblasts, scar forming cells that are responsible for the generation of extracellular matrix. Myofibroblasts are considered to be an important determinant in the etiology of fibrosis and inhibiting myofibroblast differentiation has become an important target for therapy. In order to better understand this process we collected biological samples from study participants as part of an observational study. These samples are currently undergoing metabolomic analysis. By defining the metabolic profile of IPF we can postulate which pathways may be dysregulated and are thus contributing to disease progression. The data generated from this will present novel opportunities for pharmaceutical therapy that can increase the life expectancy of patients with IPF and ultimately lead to a cure. I also participated in in vitro laboratory research investigating protein expression of pro-fibrotic lung tissue and observed IPF clinic patient visits at the U of R as part of a clinical shadowing component. This internship allowed me to experience how biomedical research and observational studies are conducted in a fast-paced, dynamic medical setting.
Internship Title: Newborn Screening Quality Improvement: Case Management and Hospital Education - Phase V
Internship Mentors: Kathleen Fiato, Beth Vogel and Joseph Orsini
Summary: My summer internship took place within the Department of Health- Newborn Screening Follow-Up Unit which is housed in the Biggs Laboratory within the Wadsworth Center at the Empire State Plaza and my goal was to improve the quality of the newborn screens that are received by the laboratory. As of August 20th, the Newborn Screening Lab had received 158,354 specimens for screening, but 3,952 (2.5%) of which were unsuitable for testing, primarily due to poor collection technique. My role was to identify hospitals with a high number of unsuitable specimens and work with them to provide additional resources and address educational concerns in order to help them improve their rates. My focus involved direct, daily communication with several of these target hospitals by providing early notification of an unsuitable specimen, information regarding the error rate of a specific specimen collector, photographs of unsuitable specimens, or any further assistance or educational resources that they requested.
The primary issue with an unsuitable specimen is that by the time it is collected, dried, mailed (overnight), received by the lab and analyzed for validity, the turnaround time is 2-3 days. With the exception of those babies admitted to the NICU, most infants are discharged within 2-3 days of birth and thus, no longer available for an immediate repeat collection. It then becomes the birth hospital or attendant’s legal responsibility to contact the parent and have her/him bring the baby to their pediatrician, or the hospital, to be retested. Although the majority of initial unsuitable specimens are resubmitted successfully, many are invalid a second or subsequent time or the infant is lost to follow-up after discharge. The easiest and most efficient way to avoid having to deal with the issues surrounding an unsuitable specimen is to ensure the validity of the initial sample.
In addition, my responsibilities included working with the other members of the follow-up unit by performing individual case reviews and assessments, reporting and documenting communication with hospitals and pediatrician offices, providing outreach and education for newborn coordinators and working cooperatively to help resolve collection and unsuitability issues.
New Faces of BMS
Below are the "New Faces of BMS" pamphlets. These pamphlets were created to introduce all of the incoming students to the faculty, staff and current students.
Incoming class of 2011
Incoming class of 2012
Incoming class of 2013
Incoming class of 2014 photo directory
Incoming class of 2015
Useful Student Resources
University at Albany Resources
UAlbany Graduate Student Association
ARES - Electronic Reserve
Student Financial Center
Disability Resource Center
Reasonable Accommodation Policy
Other Useful Resources
BMS Department Resources
BMS Student Handbook (January 2015)
BMS Class Schedule (Fall 2016)
BMS Course Descriptions