Douglas Conklin

Douglas Conklin, PhD

Functional genomics of cellular proliferation regulation, mammalian cell genetics.

The World Within Reach
Douglas Conklin, PhD
Associate Professor

School of Public Health
Department: Biomedical Sciences

308 Cancer Research Center
Personal Pages:



Ph.D., University of Wisconsin-Madison
Postdoctoral: Cold Spring Harbor Laboratory

Research Interests

Functional genomics of cellular proliferation regulation, mammalian cell genetics.



  • Kourtidis, A., R. Jain, R.D. Carkner, C. Eifert, M.J. Brosnan and D.S. Conklin, 2010. An RNAi screen identifies metabolic regulators NR1D1 and PBP as novel survival factors for breast cancer cells with the ERBB2 signature.                                                                                                                                       Cancer Res. 70(5):1783-92
  • Kourtidis, A., R. Srinivasaiah, R.D. Carkner, M.J. Brosnan and D.S. Conklin, 2009. PPARgamma protects ERBB2-positive breast cancer cells from palmitate toxicity.                                                                                                                   Breast Cancer Res.11(2):R16
  • Adam, A.P., A. George, D. Schewe, P. Bragado, B.V. Iglesias, A.C. Ranganathan, A. Kourtidis, D.S. Conklin and J.A. Aguirre-Ghiso, 2009. Computational identification of a p38SAPK-regulated transcription factor network required for tumor cell quiescence.                                                 Cancer Res. 69(14):5664-72
  • Ranganathan, A.C., A. Kourtidis, S. Ojha, A. Kourtidis, D. S. Conklin and J. A. Aguirre-Ghiso. 2008. Dual function of pancreatic endoplasmic reticulum kinase in tumor cell growth arrest and survival.
    Cancer Res. 68(9):3260-8
  • Evans, S., A. Kourtidis, T. S. Markham, J. Miller, D. S. Conklin and A. Torres, 2007. microRNA target detection and analysis for genes related to breast cancer using MDLcompress.
    EURASIP Journal on Bioinformatics and Systems Biology vol. 2007, Article ID 43670


  • Lastro, M.L., A. Kourtidis, K. Farley, and D.S. Conklin, 2008.
    xCT expression reduces the early cell cycle requirement for calcium.
    Cell. Signal. 20:390-399
  • O'Connell, C. B., J. Loncarek, P. Hergert, A.Kourtidis, D.S. Conklin, and A. Khodjakov, 2008. The spindle assembly checkpoint monitors attachment and not tension during mitosis with an unreplicated genome (MUG).
    J Cell Biol. 183(1):29-36


  • Paddison, PJ, Silva, JM, Conklin, DS, Schlabach, M., Li, M., Aruleba, S., Balija, V., O Shaughnessy, A., Gnoj, L., Scobie, K., Chang,K., Westbrook,T., Sachidanandam, R., McCombie, WR, Elledge SJ and Hannon, GJ, 2004. A resource for large-scale RNAi based screens in mammals.
    Nature 428, 427 - 431
  • Carmell, M.A., L. Zhang, D.S. Conklin, G.J. Hannon, and T.A. Rosenquist, 2003.
    Germline transmission of RNAi in mice.
    Nat Struct Biol 10:91-2
  • McCaffrey, A.P., L Meuse, T-T T. Pham, D.S. Conklin, G.J. Hannon, and M.A. Kay, 2002. RNA interference in adult mice.
    Nature 418:38-9
  • Paddison P. J. , A. A. Caudy, E. Bernstein, G.J. Hannon and D.S. Conklin, 2002.
    Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells.
    Genes Dev. 16:948-58
  • Hannon, G.J., P.Q. Sun, A. Carnero, L. Xie, R. Maestro, D.S. Conklin, and D. Beach, 1999. MaRX: An approach to genetics in animal cells.
    Science 283:1129-1130


  • Rooney, J. P., A. George, A. Patil, U. Begley, E. Bessette, M. Zappala, X. Huang, D.S. Conklin, R.P. Cunningham and T.J. Begley, 2009. Systems based mapping demonstrates that recovery from alkylation damage requires DNA repair, RNA processing, and translation associated networks.
    Genomics 93:42-51
  • Rooney, J. P., A. Patil, D.S. Conklin, R.P. Cunningham and T.J. Begley, 2008. A molecular bar-coded DNA repair resource for pooled toxicogenomic screens.
    DNA Repair 7:1855-68
  • Begley, U., M. Dyavaiah, A. Patil, J. P. Rooney, D. DiRenzo, C.M. Young, D.S. Conklin, R.S. Zitomer and T.J. Begley, 2007. Trm9 catalyzed tRNA modifications link translation to the DNA damage response.
    Mol. Cell 28:860-870