Drug Discovery & Therapeutics

Faculty in this concentration use a variety of computational and experimental approaches directed at advancing therapeutic interventions against various diseases. These approaches include virtual screening to identify potential inhibitors for specific enzyme targets, development of both traditional biochemical assays and high-throughput screening assays for inhibitor identification, synthetic drug design, identification of drug resistance mutations, design and discovery of novel antibodies, pathogen inhibition studies, and inhibitor toxicity studies. These efforts are typically pursued in close collaboration with leading external research groups in academia and industry. The areas targeted, which include cancer, neurological diseases, Zika virus, dengue virus, West Nile virus, tuberculosis, Lyme disease, and ricin toxin, are of major concern for public health or biodefense.