Anwar Y. Dunbar, Ph.D.


Academic Appointment Title:
Adjunct Assistant Professor
Environmental Health Sciences

Contact Information:
Address: 
1200 Pennsylvania Ave, NW
Washington, DC 20460

Phone Number:    (734)330-1710
Additional Phone: (703) 603-0611      
Fax Number:         (703) 305-0871            
Email Address:     dunbar.anwar@epa.gov

Education:
Ph.D. Pharmacology
University of Michigan 2005
B.S. General Biology
Johnson C. Smith University

Research Interests:
Dr. Dunbar’s dissertation defense project was titled the “Labilization and Proteasomal Degradation of Neuronal Nitric Oxide Synthase.”  His project involved determining the chemical specific mechanisms by which heme-based proteins are selectively targeted for proteolysis within the cell.  As a postdoctoral scientist, Dr. Dunbar worked on the characterization of the then orphan Cytochrome P450, 2S1.  He also gained considerable experience performing airway inhalation exposure toxicity studies.  Dr. Dunbar currently works as pharmacologist/toxicologist within the Environmental Protection Agency’s Office of Pesticide Programs/Human Health Effects Division.  There he plays an important role in the registration of pesticides by evaluating and characterizing the hazard profiles of various active ingredients.  These characterizations serve as the basis for the risk assessment of pesticides which are used throughout the United States and the world.

Select Publications:
Dunbar AY, Jenkins GJ, Jianmongkol S, Nakatsuka M, Lowe ER, Lau M and Osawa Y (2006)  Tetrahydrobiopterin protects against Guanabenz-mediated inactivation of neuronal nitric oxide synthase in vivo and in vitro. Drug Metab Dispos 34: 1448-1456.
http://dmd.aspetjournals.org/content/34/9/1448.long

Dunbar AY, Kamada Y, Jenkins GJ, Lowe ER, Billecke SS and Osawa Y (2004)  Ubiquitination and degradation of neuronal NO-synthase in vitro: Dimer stabilization protects the enzyme from proteolysis. Mol Pharmacol 66: 964-969.
http://molpharm.aspetjournals.org/content/66/4/964.long