The RNA Institute Staff: Ken Halvorsen
Senior Research Scientist
- Single-molecule biophysics
- Instrument and method development
- Optical micromanipulation
Ken Halvorsen joins the RNA Institute as the Lab Manager for the Advanced Instrumentation Facility. In addition to managing the facilities and training users on equipment, Ken will work with academic and industrial affiliates to develop new technologies for RNA research. Ken has a decade of expertise in single-molecule biophysics and a track record of developing innovative new technologies and experiments to investigate biology at the nanoscale. He spent the last 6 years as a postdoctoral fellow and research associate in Wesley Wong's lab at Boston Children's Hospital, Harvard Medical School, and formerly the Rowland Institute at Harvard University. Ken's major accomplishments include co-inventing and developing the Centrifuge Force Microscope (CFM) for highly multiplexed single-molecule manipulation, elucidating the role of force on the regulation of blood clotting, and developing a DNA-based nanoswitch for analyzing biomolecular interactions. His work has resulted in 12 publications and 4 pending patents.
BS in Mechanical Engineering and Physics, Clarkson University
PhD in Biomedical Engineering, Boston University
- W. Zhao, C.H. Cui, S. Bose, D. Guo, C. Shen, W.P. Wong, K. Halvorsen, O.C. Farokhzad, G.S.L. Teo, J.A. Phillips, D.M. Dorfman, R. Karnik, and J.M. Karp, “A bioinspired multivalent DNA network for capture and release of cells,” PNAS 109, 19626-19631.
- J. Pelletier*, K. Halvorsen*, B.-Y. Ha, R. Paparcone, S. Sandler, C. Woldringh, W.P. Wong, and S. Jun, “Physical manipulation of the Escherichia coli chromosome reveals its soft nature,” PNAS 109, E2649-E2656 (2012).
- K. Halvorsen and W.P. Wong, “Binary DNA nanostructures for data encryption,” PLoS ONE 7, e44212 (2012).
- K. Halvorsen, D. Schaak, and W.P. Wong, “Nanoengineering a single-molecule mechanical switch using DNA self-assembly,” Nanotechnology 22, 494005 (2011).
- K. Halvorsen and W.P. Wong, “Massively parallel single-molecule manipulation using centrifugal force,” Biophysical Journal 98, L53-L55 (2010).
- D. Cheng, K. Halvorsen, and W.P. Wong, “High precision microsphere sorting with velocity sedimentation,” Review of Scientific Instruments 81, 026106 (2010).
- X. Zhang*, K. Halvorsen*, W.P. Wong, and T.A. Springer, “Mechanoenzymatic cleavage of the ultralarge vascular protein, von Willebrand Factor,” Science 324, 1330-1334 (2009).
- E. Evans, K. Halvorsen, K. Kinoshita, and W.P. Wong, "A New Approach to Analysis of Single Molecule Force Measurements." Handbook of Single-Molecule Biophysics, P. Hinterdorfer, ed., Springer (2009).
- W.P. Wong* and K. Halvorsen*, "Beyond the frame rate: Measuring high-frequency fluctuations with light intensity modulation," Optics Letters 34, 277-279 (2009).
- V. Heinrich, W.P. Wong, K. Halvorsen, and E. Evans, “Imaging Biomolecular Interactions by Fast Three-Dimensional Tracking of Laser-Confined Carrier Particles,” Langmuir 24, 1194-1203 (2008)
- K. Halvorsen, “Probing weak single-molecule interactions: development and demonstration of a new instrument,” Ph. D Thesis, Department of Biomedical Engineering, Boston University, USA (2007).
- W.P. Wong* and K. Halvorsen*, "The effect of integration time on fluctuation measurements: calibrating an optical trap in the presence of motion blur," Optics Express 14, 12517-12531 (2006).
- W.P. Wong and K. Halvorsen, Nucleic acid-based linkers for detecting and measuring interactions.” US Patent Provisional 61556194 (2011).
- W.P. Wong and K. Halvorsen, Spinning force apparatus.” US Patent Provisional 61350088 (2010).
- W.P. Wong and K. Halvorsen, “Methods, apparatus, and systems for determining power spectral density of a signal via modulation of the signal.” US Patent Application 61086336 (2008).
- W.P. Wong and K. Halvorsen, “Spinning force apparatus.” US Patent Application 12326279 (2008).