University at Albany
 

Physics Faculty

Alexander Khmaladze

Assistant Professor
Office: Physics 111
Telephone: (518) 442-4520
Email: akhmaladze@albany.edu

Academic History:
  • Ph.D. in Applied Physics, University of South Florida (2008)
  • Postdoctoral Researcher, University of Michigan (2008 – 2013)
  • Assistant Professor, University at Albany (2014-present)
Research Areas:
  • Raman spectroscopy and microscopy, three-dimensional digital holographic imaging, scanning microscope design, hyperspectral imaging of live cells via Coherent Anti-Stocks Raman Scattering (CARS) microscopy and biological tissue imaging.
Current Research:
The non-invasive nature of optical techniques enables researchers to study a great variety of materials under conditions approaching or similar to their "natural" environment. This is especially relevant to live biological specimens, which can be studied both in-vitro and in-vivo, providing a unique insight into the dynamic processes occurring in live organisms. In recent years, the emphasis has been shifting towards the technologies that combine several different imaging techniques to study a particular biological system. Each technique then allows measuring a partially overlapping set of parameters, leading to deeper understanding of the processes occurring within that system. Having been trained as physicist who specializes in microscopic imaging and spectroscopy, I have gradually expanded my work into the domains of chemistry and biology. Due to interdisciplinary nature of this work, it is particularly well-suited for involving students from various scientific backgrounds and interests. Thus, my research provides rich opportunities to explore and gain practical skills in optical design, software programming, mathematics and biology.
Publications
  • Khmaladze , S. Kuo, R. Y. Kim, R. V. Matthews, C. L. Marcelo, S. E. Feinberg, M. D. Morris "Human Oral Mucosa Tissue-Engineered Constructs Monitored by Raman Fiber-Optic Probe", Tissue Eng. C ahead of print, (July 2014)

  • Khmaladze , J. Jasensky, E. Price, C. Zhang, A. Boughton, X. Han, E. Seeley, X. Liu, M. M. Banaszak Holl, Z. Chen, "Hyperspectral Imaging and Characterization of Live Cells by Broadband Coherent Anti-Stokes Raman Scattering (CARS) Microscopy with Singular Value Decomposition (SVD) Analysis", Appl. Spectrosc. 68, 10 (2014)

  • J.-D. McElderry, G. Zhao, A. Khmaladze, C. Wilson, R. Franceschi, M. Morris, "Tracking Circadian Rhythms of Bone Mineral Deposition in Murine Calvarial Organ Cultures", Journal of Bone and Mineral Research, Vol. 28, No. 8, (2013).

  • A. Khmaladze , A. Ganguly, S. Kuo, M. Raghavan, R. M. Kainkaryam, J. H. Cole, C. L. Marcelo, S. E. Feinberg, K. Izumi, M. D. Morris, "Examination of Human Tissue Engineered Oral Mucosa Constructs by Raman Spectroscopy", Tissue Engineering C Vol. 19, No. 4 (2013).

  • A. Khmaladze , A. Ganguly, M. Raghavan, S. Kuo, J. H. Cole, C. L. Marcelo, S. E. Feinberg, K. Izumi, M. D. Morris, "Raman spectroscopic analysis of human tissue engineered oral mucosa constructs (EVPOME) perturbed by physical and biochemical methods", Proc. SPIE 8219, 82190J (2012)

  • A. Khmaladze , R. L. Matz, J. Jasensky, E. Seeley, M. M. Banaszak Holl, Z. Chen, "Dual-Wavelength Digital Holographic Imaging with Phase Background Subtraction", Optical Engineering Vol. 51, No. 5, 055801-055801-8 (2012).

  • A. Khmaladze , R. L. Matz, T. Epstein, J. Jasensky, M. M. Banaszak Holl, Z. Chen, "Cell Volume Changes During Apoptosis Monitored in Real Time Using Digital Holographic Microscopy", Journal of Structural Biology Vol. 178, No. 3, 270–278 (2012).

  • A. Khmaladze , J. Jasensky, C. Zhang, X. Han, J. Ding, E. Seeley, X. Liu, G. D. Smith, Z. Chen, "Hyperspectral microscopic imaging by multiplex coherent anti-Stokes Raman scattering (CARS)", Proc. SPIE 8158, 815805 (2011)

  • C. Zhang, J. Wang, A. Khmaladze, Y. Liu, B. Ding, J. Jasensky, Z. Chen, "Examining Surface and Bulk Structures Using Combined Nonlinear Vibrational Spectroscopies," Optics Letters Vol. 36 No. 12, 2272-2274 (2011).

  • T. Wang, D. Li, X. Lu, A. Khmaladze, X. Han, S. Ye, P. Yang, Z. Chen, N. He, "Single Lipid Bilayers Constructed on Polymer Cushion Studied by Sum Frequency Generation Vibrational Spectroscopy," Journal of Physical Chemistry C Vol. 115, No 15, 7613–7620 (2011).

  • A. Khmaladze , R. L. Matz, C. Zhang, T. Wang, M. M. Banaszak Holl, Z. Chen, "Dual-Wavelength Linear Regression Phase Unwrapping in Three-Dimensional Microscopic Images of Cancer Cells", Optics Letters Vol. 36, No.6, 912-914 (2011).

  • A. Khmaladze , T. Epstein, Z Chen "Phase Unwrapping by Varying the Reconstruction Distance in Digital Holographic Microscopy", Optics Letters Vol. 35, No. 7, 1040-1042 (2010).

  • A. Khmaladze , M. K. Kim, C-M. Lo "Phase Imaging of Cells by Simultaneous Dual-Wavelength Reflection Digital Holography", Optics Express Vol. 16, No. 15, 10900-10911 (2008).

  • A. Khmaladze , A. Restrepo-Martínez, M. K. Kim, R. Castañeda, A. Blandón, "Simultaneous Dual-Wavelength Reflection Digital Holography Applied to the Study of the Porous Coal Samples", Applied Optics Vol. 47, No. 17 3203-3210 (2008).

  • A. Khmaladze , M. Kim, "Design and Imaging Properties of a Laser Scanning Microscope with a Position-Sensitive Detector", Journal of Modern Optics Vol. 55 No. 17, 2785-2796 (2008)

  • A. Khmaladze , M.K. Kim "Use of Bessel Beams and Position-Sensitive Detectors in Scanning Photon Microscope for Improved Field Depth and Contrast", Proc. SPIE, 6090, 173-180 (2006).

  • A. Khmaladze , M.K. Kim "Scanning Photon Microscope", Proc. SPIE, 5873, 156-162 (2005).

Book Chapters

  • A. Khmaladze "Phase unwrapping problems in phase microscopy of biological cells ", in Biomedical Optical Phase Microscopy and Nanoscopy, (Elsevier, 2012).

  • A. Khmaladze "The analysis of hyperspectral broadband coherent anti-Stokes Raman scattering (CARS) microscopic images", in Current microscopy contributions to advances in science and technology (Formatex, 2012).

Conference proceedings

  • A. Khmaladze , R. L. Matz, J. Jasensky, E. Seeley, M. M. Banaszak Holl, Z. Chen, "Dual wavelength digital holographic imaging of cells with phase background subtraction", in Digital Holography and Three Dimensional Imaging Topical Meeting, (Optical Society of America, 2012), paper DSu3C.2

  • A. Khmaladze , R. L. Matz, J. Jasensky, T. Epstein, C. Zhang, M. M. Banaszak Holl, Z. Chen, "Dynamic Cellular Volume Measurements by Single and Dual-Wavelength Digital Holographic Microscopy", in Digital Holography and Three Dimensional Imaging Topical Meeting, (Optical Society of America, 2011), paper DWD4

  • A. Khmaladze , R. L. Matz, C. Zhang, M. M. Banaszak Holl, Z. Chen "Dual wavelength digital holography phase unwrapping by linear regression", Proc. SPIE 8043, 80430X (2011);

  • A. Khmaladze , R. L. Matz, J. Jasensky, T. Epstein, C. Zhang, M. M. Banaszak Holl, Z. Chen, "The Study of Apoptotic Morphological Changes by Dual-Wavelength Digital Holographic Microscopy", in CLEO: Applications and Technology & Science and Innovations, (Optical Society of America, 2011) Paper JWA101

  • A. Khmaladze , R. L. Matz, T. Epstein, C Zhang, M. M. Banaszak Holl, R Kopelman, Z Chen "Phase unwrapping by varying the reconstruction distance in digital holographic microscopy", in Digital Holography and Three-Dimensional Imaging (DH), Technical Digest (CD), (Optical Society of America, 2010), paper JMA8.

  • T. Wang, A. Khmaladze, H. Xu, G. Kim, N. Y. He, Z. Chen, M. Philbert, "Interactions between nanoparticles and cell membranes", Abstracts of Papers of the American Chemical Society, Vol. 238, Meeting Abstract: 459-COLL (2009)

  • A. Khmaladze , A. Restrepo-Martínez, M.K. Kim, R. Castañeda, A. Blandón, "The Application of Dual-Wavelength Reflection Digital Holography for Detection of Pores in Coal Samples", in Digital Holography and Three-Dimensional Imaging (DH), (Optical Society of America, 2008), paper DMB5.

  • A. Khmaladze , C.J. Mann, M.K. Kim "Phase Contrast Movies of Cell Migration by Multi-Wavelength Digital Holography", in Digital Holography and Three-Dimensional Imaging (DH), (Optical Society of America, 2007), paper DMB3.

  • A. Khmaladze , M. Kim, "Quantitative Phase Contrast Imaging of Cells by Multi-Wavelength Digital Holography", in Conference on Lasers and Electro-Optics (CLEO), (Optical Society of America, 2007), paper JTuA52.

  • C. Mann, A. Khmaladze, M.K. Kim "Phase Contrast Movies of Cell Migration by Multi-Wavelength Digital Holography", in Conference on Lasers and Electro-Optics (CLEO), (Optical Society of America, 2006), paper CTuG5.

  • A. Khmaladze , M.K. Kim "Imaging Properties of Scanning Photon Microscope", in Biomedical Topical Meeting (BIO), (Optical Society of America, 2006), paper TuI74.