Research

The Pager lab is interested in the interaction and mechanisms by which RNA viruses subvert the cellular RNA metabolism pathways.

 

We are particularly intrigued by how flaviviruses such as hepatitis C virus and Dengue virus commandeer the host’s mRNA storage and decay machinery to successfully establish an infection.

 

We have identified specific components found in RNA granules that interact with the viral RNA to manipulate the shape of the viral RNA to affect translation and replication of the viral RNA, as well as virus assembly.

 

By understanding the molecular biology of these viruses, our goal is to identify novel targets for antiviral treatments.