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Study Links High Manganese Levels with IQ Scores in Children

ALBANY, N.Y. (September 28, 2017) -- Can a chemical element critical for brain growth and development cause lower IQ and memory problems when found in excessive amounts? That appears to be the case according to a new study involving researchers from UAlbany's School of Public Health.

The study, led by environmental health researchers at the University of Cincinnati (UC) College of Medicine finds that children in East Liverpool, Ohio with higher levels of Manganese (Mn) had lower IQ scores. The research appears online in the journal NeuroToxicology.

The study analyzed blood and hair samples of 106 children 7 to 9 years of age from East Liverpool, Ohio, and surrounding communities, who enrolled in the study from March 2013 to June 2014. Working with a trained registered nurse from East Liverpool, participants and their caregivers were also given cognitive assessments and questionnaires at the time the samples were taken.

The study found that increased Mn in hair samples was significantly associated with declines in full-scale IQ, processing speed and working memory.

Manganese is an element generally found in combination with iron and many minerals. It plays a vital role in brain growth and development, but excessive exposure can result in neurotoxicity. Manganese is used widely in the production of steel, alloys, batteries and fertilizers and is added to unleaded gasoline.

Erin Haynes, DrPH, associate professor in the Department of Environmental Health and lead author of the study, was approached by East Liverpool school district officials in 2013, prompted by concerns of students' academic performance, paired with the knowledge that Mn concentrations in the area have exceeded U.S. Environmental Protection Agency (EPA) reference levels for more than a decade.

"There are socioeconomic issues at play, however, they are also compounded by potentially significant environmental exposures," says Haynes, who collaborated with the Kent State East Liverpool Campus and the community group Save our County Inc., formed in 1982 by East Liverpool residents in response to the proposed construction of a hazardous waste incinerator in their community. "Children may be particularly susceptible to the neurotoxic effects of ambient Mn exposure, as their brains are undergoing a dynamic process of growth and development."

Patrick J. Parsons
Professor and Chair of Environmental Health Sciences Patrick J. Parsons

After concerns of elevated airborne levels of Mn, the school district superintendent in East Liverpool requested testing students for manganese along with neuropsychological tests. A pilot study overseen by Haynes found levels of Mn at double the level in children from the other CARES study cohort, and further investigation was pursued to examine the association between Mn exposure and child cognition.

Located in northeast Ohio along the Ohio River, East Liverpool has a demonstrated history of environmental exposures, with EPA records showing elevated levels of manganese concentrations since 2000. In 2005, East Liverpool was deemed by the EPA to be a potential environmental justice area, afflicted with major environmental exposures, and a 2010 EPA report noted manganese concentrations detected by all monitors in East Liverpool had "consistently exceeded" health-based guidelines set by the agency.

With a declining population of just 11,000, just 7.3 percent of East Liverpool residents have a college degree. The East Liverpool school district reports a higher than average percentage of students in special education (19 percent) versus the Ohio state average of 13 percent.

Patrick J. Parsons, professor and chair of Environmental Health Sciences at the School of Public Health coauthored the study along with Haynes and researchers from Cincinnati Children's Hospital Medical Center, Icahn School of Medicine at Mount Sinai, and Kent State University East Liverpool Campus.

Parsons also serves as the director of the Inorganic and Nuclear Chemistry Laboratory at the New York State Department of Health's Wadsworth Center.

The research was supported by the National Institute of Environmental Health Sciences (R01ES016531, R21ES021106, and P30-ES06096) and NIH/NCRR8UL1TR000077.

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