David Frank
Senior Research Support Specialist
DNA Microarray Core Facility
Academic Background
- B.S. (Biology) 1989, SUNY Cortland, NY
- A.S. (Liberal Arts) 1987 Tompkins-Cortland Community College Dryden, NY
Professional Background
- Research Associate/Bioinformatics at Myriad Genetics, Inc., Salt Lake City, UT (1996-2005)
- Biomedical Research Technician at Naval Medical Research Institute, Bethesda, MD (1992-1995)
- Research Assistant II at Boyce Thompson Institute for Plant Research at Cornell University, Ithaca, NY (1989-1991)
Research Experience
- In silico analysis of genes identified as interesting by RNA expression profiling experiments or by genotyping. Maintained/administered sequence databases used for mutation screening in prostate cancer, obesity and pharmacogenomics projects. Scouted and tested new sequence analysis software.
- Developed and implemented PCR based assays for detection of various agents of bio-warfare as part of a biological warfare defense program; measuring the incidence of Mycoplasma spp. infection in patients with and without HIV infection; and the rapid diagnosis of bacterial meningitis.
- Conducted biochemical and molecular biology research on the growth and differentiation of the fungal entomopathogen Metarhizium anisopliae.
Selected Publications
Stone S, Abkevich V, Russell DL, Riley R, Timms K, Tran T, Trem D, Frank D, Jammulapati S, Neff CD, Iliev D, Gress R, He G, Frech GC, Adams TD, Skolnick MH, Lanchbury JS, Gutin A, Hunt SC, Shattuck D.
TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition.
Hum Mol Genet. 2006 Sep 15;15(18):2709-20Martine Dumont, David Frank, Anne-Marie Moisan, Martine Tranchant, Penny Soucy, Rock Breton, Fernand Labrie, Sean V. Tavtigian and Jacques Simard.
Structure of primate and rodent orthologs of the prostate cancer susceptibility gene ELAC2.
Biochim Biophys Acta. 2004 Sep 17;1679(3):230-47Victor Abkevich, Andrey Zharkikh, Amie M. Deffenbaugh, David Frank, Yuan Chen, Donna Shattuck, Mark H. Skolnick, Alexander Gutin, Sean V. Tavtigian.
Analysis of missense variation in human BRCA1 in context of interspecific sequence variation.
Journal of Medical Genetics 2004 July 41:492-507,Tavtigian SV, Simard J, Teng DH, Abtin V, Baumgard M, Beck A, Camp NJ, Carillo AR, Chen Y, Dayananth P, Desrochers M, Dumont M, Farnham JM, Frank D, Frye C, Ghaffari S, Gupte JS, Hu R, Iliev D, Janecki T, Kort EN, Laity KE, Leavitt A, Leblanc G, McArthur-Morrison J, Pederson A, Penn B, Peterson KT, Reid JE, Richards S, Schroeder M, Smith R, Snyder SC, Swedlund B, Swensen J, Thomas A, Tranchant M, Woodland AM, Labrie F, Skolnick MH, Neuhausen S, Rommens J, Cannon-Albright LA.
A candidate prostate cancer susceptibility gene at chromosome 17p.
Nature Genetics 2001 Feb; 27(2):172-80.Teng DH, Perry WL 3rd, Hogan JK, Baumgard M, Bell R, Berry S, Davis T, Frank D, Frye C, Hattier T, Hu R, Jammulapati S, Janecki T, Leavitt A, Mitchell JT, Pero R, Sexton D, Schroeder M, Su PH, Swedlund B, Kyriakis JM, Avruch J, Bartel P, Wong AK, Tavtigian SV.
Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor.
Cancer Research 1997 Oct 1;57(19):4177-4182.St. Leger, R.J., Frank, D.C., Roberts, D.W., and Staples, R.C.
Molecular cloning and regulatory analysis of the cuticle-degrading-protease structural gene from the entomopathogenic fungus Metarhizium anisopliae.
European Journal of Biochemistry 1991 204:991-1001St. Leger, R.J., May, B., Allee, L.L., Frank, D.C., and Roberts, D.W.
Genetic differences in allozymes and in formation of infection structures among isolates of the entomopathogenic fungus Metarhizium anisopliae.
Journal of Invertebrate Pathology 60:89-101