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Department of Biological Sciences
  Faculty
Sho-Ya Wang
Publications
  • Wang, S-Y., Roguska, M.A. and Gudas, L.J. Defective post-translational modification of collagen IV in a mutant F9 teratocarcinoma cell line is associated with delayed differentiation and growth arrest in response to retinoic acid. J. Biol. Chem. 264:15556-15564 (1989).


  • Wang, S-Y. and Gudas, L.J. A retinoic acid inducible mRNA from F9 teratocarcinoma cells encodes a novel protease inhibitor homologue. J. Biol. Chem. 265:15818-15822 (1990).


  • Wang, G.K. and Wang, S-Y. Inactivation of batrachotoxin-modified Na+ channels in GH3 cells: characterization and pharmacological modification. J. Gen. Physiol. 99:1-20 (1992).


  • Wang, S-Y. Structure of the gene and its retinoic acid regulatory region for murine J6 serpin - a F9 teratocarcinoma cell retinoic acid inducible protein. J. Biol. Chem. 267:15362-15366 (1992).


  • Wang, G.K., and Wang, S-Y. Altered stereoselectivity of cocaine and bupivacaine isomers in normal and batrachotoxin-modified Na+ channels. J. Gen. Physiol. 100:1003-1020 (1992).


  • Wang, S-Y. A retinoid acid inducible GATA binding protein binds to the regulatory region of J6 serpin gene, J. Biological Chemistry. 269:607-613 (1994)


  • Wang, G.K. & Wang, S-Y. Binding of Banzocaine in Batrachotoxin Modified Na+ channels: State Dependent Interaction. J. Gen. Physiol. 103:501-518 (1994)


  • Henle, K. J., Wang, S-Y., Nagle, W. A., and Lumpkin, C. K. Heat shock glycoprotein GP50: Product of the Retinoic Acid-Inducible J6 Gene. Exptl. Cell Res. (1994). 210:185-191.


  • Wang, S.-Y. And Wang, G. K. A mutation in segment I-S6 alters the C-type inactivation of sodium channels. Biophysical J. 2:11633-11640 (1997).


  • Wang, S.-Y. And Wang, G. K. Point Mutations in Segment I-s6 Render Voltage-gated Na+ Channels Resistant to Batrachotoxin. Proc. Natl. Acad. Si. USA 95:2653-2658 (1998).


  • Wang, G. K., c. Quan and Wang S.-Y., Local Anesthetic Block of Batrachotoxin-resistant Muscle Na Channels. Molecular Pharmacology, 54:389-396 (1998).


  • Wright, S.,. Wang S.-Y, & G. K. Wang, State Dependant Cocaine Block of Na Channel Isoforms, Chimeras and Channels Coexpressed with the Betal Subunit, Biophysical J. 76:233-245 (1999)


  • Wang, S-Y, G. K. Wang, Batrachotoxin-resistant Na+ Channels Derived From Point Mutations in Transmembrane Segment D4-S6. Biophys J. 76:3141-3149 (1999).


  • Nau,C. Wang S.-Y., G. R. Strichartz, G. K. Wang. Point Mutations at N434 in D1-S6 of µl Na+ Channels Modulate Binding Affinity and Stereoselectivity of Local Anesthetic Enantiomers. Mol. Pharmacol. 56:404-413 (1999)


  • O'Reilly, J.P., Wang S-Y. and G. K. Wang. A point mutation in domain 4-segment 6 of the skeletal muscle sodium channel produces an atypical inactivation state. Biophys J. 78:773-784 (2000).


  • Nau, C., M. Seaver, Wang S-Y., and G. K. Wang. Block of human heart hH1 sodium channels by amitriptyline. J. Pharmacology & Experimental Therapeutics 292:1015-1023 (2000)


  • Wang, G. K., Quan, C., Seaver, M. and Wang, S-Y. Modificaiton of wild-type and batrachotoxin resistant muscle µ1 Na+ channels by veratridine. Pflügers Archiv 439:705-713 (2000)


  • Wang, S-Y., C. Nau, G. K. Wang. Residues in Na+ channel D3-S6 segment modulate both batrachotoxin and local anesthetic affinities. Biophys J. 79:1379-1387 (2000).


  • Wang, S-Y., Barile, M., and Wang, G. K., Disparate role of Na+ channel D2-S6 residues in batrachotoxin and local anesthetic binding. Mole. Pharmacol. 59;1-8 (2001).


  • Xiao, Y. F., Ke. O., Wang, S-Y., Auktor, K. Yang, Y., Wang, G. K., Morgan, J. P. and Leaf, A. Single point mutations affect fatty acid block of human myocardial sodium channel alpha subunit Na+ channels. Proc. Natl. Acad. Sci. USA, 98:(6);3606-3611 (2001)


Recent Publications:
  • Wang, S-Y., Barile M, and Wang GK, A phenylalanine residue at segment D3-S6 in Nav1 voltage-gated Na channels is critical for Pyrethroid action. Mol Pharmacology 60: 620-628, September (2001).


  • O'Reilly J, Wang GK, and Wang S-Y. Residue-specific effects at V787 in D2-S6 on slow activation in Na v 1.4 sodium channels. Biophysical J. 81:2100-2111 (2001).


  • Rathee, P.K., Distler, C., Obreja, O., Neuhuber, W., Wang, GK, Wang, S-Y., Nau, C., and Kress, M. PKA/AKAP/VR-1 module: a common link of Gs-mediated signaling to thermal hyperalgesia. J. Neuroscience 22, 4740-4745 (2002).


  • Mujtaba, M.G., Wang, S-Y, and Wang , G.K. Prenylamine block of Nav 1.5 channel is mediated via a receptor distinct form that of local anesthetics. Molecular Pharmacology 62, 415-422 August ( 2002).

  • Wang, G.K. and Wang, S-Y. Modification of Human Cardiac Sodium Channel Gating by UVA light: Via an oxidative pathway. J. Membrane Biology 189, 153-165 September (2002).

  • Wang, S-Y. and Wang, G.K. Voltage-Gated Sodium Channels as Primary Targets of Diverse Lipid-Soluble Neurotoxins. Cellular Signalling 15, 151-159 March (2003).

  • Nau C., S-Y. Wang, G.K. Wang. Point mutations at L1280 in Nav1.4 channel D3-S6 modulate binding affinity and stereoselectivity of bupivacaine enantiomers. Mol Pharmaco 63:1398-1406 (2003).

  • O'Reilly J.P., S-Y. Wang, G.K. Wang. Methanethiosulfonate-modification in rNav1.4 wild-type and cysteine-substituted mutants S1276C and L1280C alters local anesthetic affinity. J Memb Biol .193:47-55 May (2003).

  • Wang G.K., S-Y. Wang. 2003. Veratridine block of voltage-gated rNav1.4 sodium channels in the inner vestibule. J Physiol 548: 667-675 (2003).

  • Wang S-Y., K. Bonner, C. Russell, G.K. Wang. Tryptophan scanning of D1S6 and D4S6 C-termini in voltage-gated sodium channels. Biophys. J. 85:911-920 August (2003).

  • Mohapatra, D.P., Wang, S.-Y., Wang, GK., and Nau, C. A tyrosine residue in TM6 of the vanilloid receptor TRPV1 involved in desensitization and calcium permeability of capsaicin-activated currents. Molecular and Cellular Neuroscience 23, 314-324 (2003).

  • Wang, G.K., Russell, C., and Wang, S-Y. State-dependent block of rNav1.4 wild-type and inactivation-deficient mutant sodium channels by flecainide. J. General Physiol. 122: 1-11 (2003).

  • Wang, G.K., Russell, C., and Wang, S-Y., Mexiletine block of wild-type and inactivation-deficient human skeletal muscle hNav1.4 Na+ channels. J. Physiol. 554:621-633. (2004)

  • Wang,G.K., C.Russell, and S.Y.Wang. State-dependent block of voltage-gated Na+ channels by amitriptyline via the local anesthetic receptor and its implication for neuropathic pain. Pain 110:166-17(2004)

  • Xiao,Y.F., Q.Ke, S.Y.Wang, Y.Yang, Y.Chen, G.K.Wang, J.P.Morgan, B.Cox, and A.Leaf. Electrophysiologic properties of lidocaine, cocaine, and n-3 fatty-acids block of cardiac Na+ channels. Eur J Pharmacol 485:31-41. (2004)

  • Wang,S.Y., J.Mitchell, E.Moczydlowski, and G.K.Wang. Block of inactivation-deficient Na+ channels by local anesthetics in stably transfected mammalian cells: evidence for drug binding along the activation pathway. J Gen Physiol 124:691-701. (2004)

  • Wang,S.Y. and G.K.Wang.. Block of inactivation-deficient cardiac Na(+) channels by acetyl- KIFMK-amide. Biochem Biophys Res Commun. 329:780-788. (2005)
  • Wang,S.Y., C.Russell, and G.K.Wang. Tryptophan substitution of a putative D4S6 gating hinge alters slow inactivation in cardiac sodium channels. Biophys J. 88(6):3991-9. (2005).

  • Xiao YF, Ma F, Wang. SY, Josephson ME, Wang GK, Morgan JP, and Leaf A. Potent block of inactivation-deficient Na channels by N-3 polyunsaturated fatty acids. Am. J. Physiol. Cell Physiol. (2005)

  • Edrich T, Wang S Y and Wang G K State-Dependent Block of Human Cardiac hNav1.5 Sodium Channels by Propafenone. J Membr Biol 207:35-43. (2005)

  • Wang, S.Y., Jane Mitchell, Denis B. Tikhonov, Boris S. Zhorov, and Ging Kuo Wang. How batrachotoxin modifies the sodium channel permeation pathway: computer modeling and site-directed mutagenesis. Mol. Pharmacol. 69:788-795 (2006)

  • Wang GK, T Edrich, and Wang S. Y. Time-dependent block and resurgent tail currents induced by mouse β4154-167 peptide in cardiac Na+ channels. J Gen Physiol 127:277-89. (2006)

  • Sheets, P. L., P. Gerner, C. F. Wang, S. Y. Wang, G. K. Wang, and T. R. Cummins. Inhibition of Nav1.7 and Nav1.4 sodium channels by trifluoperazine involves the local anesthetic receptor. J Neurophysiol. 96:1848-1859 (2006).

  • Wang, S. Y., J. Mitchell, and G. K. Wang. .Preferential block of inactivation-deficient Na+ currents by capsaicin reveals a non-TRPV1 receptor within the Na+ channel. Pain 127:73-83. (2007)

  • Wang, S. Y., D. B. Tikhonov, B. S. Zhorov, J. Mitchell, and G. K. Wang.. Serine-401 as a batrachotoxin- and local anesthetic-sensing residue in the human cardiac Na (+) channel. Pflugers Arch.454 (2): 277-87 (2007)

  • Wang , C-F, P. Gerner, S. Y Wang, G. K. Wang. An alkaloid isolated from Aconitum bulleyanum roots, bulleyaconitine A, displays long-acting local anesthetic properties in vitro and in vivo Anesthesiology 107:82-90 (2007)

  • Wang, S. Y, Tikhonov, D.B., Mitchell, J., Zhorov, B.S., and Wang, G.K. Irreversible block of cardiac mutant Na+ channels by batrachotoxin Channels 1:179-188 (2007)

  • Wang, G.K., Calderon J., and Wang S. Y. State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine. Mol Pharmacol 73 (3):940-8 (2007)

  • Wang, C.F., Gerner, P., Schmidt, B., Xu, Z.Z., Nau, C., Wang, S-Y, Ji, R-R, and Wang, G.K. Use of bulleyaconitine A as an adjuvant for prolonged cutaneous analgesia in the rat. Anesthetics & Analgesia (2008)

  • Wang, G.K., Mitchell, J., and Wang, S. Y. Block of persistent late Na+ currents by antidepressant sertraline and paroxetine. J. Membr. Biol. 222:79-90 (2008)

  • Wang, C.F., Gerner, P., Schmidt, B., Wang, S.Y., and Wang, G. K. Prolonged Cutaneous Analgesia in Rats Induced by 3-Acetylaconitine as an Additive. Drug Development Research 69:1-6 (2008)

 

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