Use of a Bulky Base

A bulky base can minimize substitution reactions by hindering the approach to attack at carbon. Yet, they can easily abstract a proton giving the elimination product. Some commonly used strong bulky bases are t-butoxide, triethylamine, diisopropyl amine, and 2,6 dimethylpyridine.

A bulky base can minimize substitution reactions by hindering the approach to attack at carbon. Yet, they can easily abstract a proton giving the elimination product. Some commonly used strong bulky bases are t-butoxide, triethylamine, diisopropyl amine, and 2,6 dimethylpyridine.