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Course Description Discussion will address
theoretical foundations of current research at the interface of evolutionary
ecology and epidemiology. Students will complete assigned reading and
organize its analysis. Specific topics may include between-host transmission
processes, within-host pathogen dynamics, free-living pathogens, disease
virulence, models of immune response, and evolution of antibiotic resistance.
The first two meetings will address alternative (competing) mathematical
formulations for transmission of infection.
Grading will be S/U, 2 credit hours.
Class will meet once pre week; day and time will be arranged during the initial
week of the Fall 08 semester.
Rob de Boer, U Utrech (NL), provides a free,
on-line textbook for students of
theoretical biology. This semester's version of Bio 612 will not address models explicity presented in
Modeling Population Dynamics: a Graphical Approach, but we shall draw on general principles
included in the text.
As class meetings begin, links to assigned papers will appear below.
| Modeling Infection Transmission |
Mart De Jong et al., 1995 |
Hans Heesterbeek et al., 1995 |
| Print the paper by De Jong et al. before reading. |
| Considering Transmission Dynamics |
Lloyd-Smith et al., 2005 |
van der Goot et al., 2005 |
| |
| Schedule of Class Meetings |
| |
| 4 September, Speaker: T. Caraco
|
Infectious Disease Dynamics |
| 11 September, Speaker: T. Caraco
|
Adaptive Dynamics: Evolution of Virulence |
| 11 September, Papers
|
van Baalen and Sabelis, 1995 |
Caraco et al., 2006 |
| 18 September, Speaker: A. Alstadt
|
Paper: Wearing et al., 2005 |
| 25 September, Speaker: A. Alstadt
|
Paper: Jeger et al., 2007 |
| 2 October, Speaker: S. Morgan
|
Paper: Choisy and Rohani, 2006 |
| 16 October, Speaker: S. Morgan
|
Paper: Ausubel et al., 2001 |
| 23 October, Speaker: P. Lathrop
|
Paper: Bonhoeffer et al., 1996 |
| 30 October, Speaker: P. Lathrop
|
Paper: Tanaka et al., 2002 |
| 6 November, Speaker: M. Stone
|
Paper: de Roode et al., 2005 |
| 13 November, Speaker: M. Stone
|
Paper: Read and Keeling, 2003 |
| 20 November, Speaker: H. Wilson
|
Paper: Ebert and Bull, 2003 |
|
A folder of papers on virulence tradeoffs |
| 4 December, Speaker: H. Wilson
|
Paper: Lipsitch, 2001 |
|