Li Niu

Publications & Patents


Patents:

  • (1) US patent 7601823, issued by the US Patent and Trademark Office (USPTO) on 10/13/2009. Nucleic Acid Ligands Specific for Glutamate Receptors. Niu, L., Huang, Z., Shi, H., & Lis, J. T.
  • (2) A divisional patent application has been submitted at the USPTO (with the priority date of Oct 24, 2005). This patent is for the target preparation methodology developed during our initial work for evolving AMPA receptor aptamers (serial number: US 11/256726). Niu, L., Huang, Z., Shi, H., & Lis, J. T.
  • (3) A provisional patent application (US 12/900,636) was submitted to the US Patent and Trademark Office (USPTO) on October 13, 2010. Conformation-selective nucleic acid inhibitors of AMPA glutamate receptors. Niu, L. & Huang, Z. (2010).

Publications:

  • Ritz, M., Wang, C., Micale, N., Ettari, R. & Niu, L. (2011) Mechanism of Inhibition of the GluA2 AMPA Receptor Channel Opening: the Role of 4-Methyl vs. 4-Carbonyl Group on the Diazepine Ring of 2,3-Benzodiazepine Derivatives. Manuscript submitted.
  • Park, J.S., Wang, C.Z., Han, Y., Huang, Z. & Niu, L. (2011) Potent and selective inhibition of a single AMPA receptor subunit by an RNA aptamer. J. Biol. Chem. In press. Epub 2011 March 14.
  • Han, Y., Wang, C.Z., Park, J.S. & Niu, L. (2010) Biochemistry 49, 9207-9216 Epub 2010 October 8. Channel-Opening Kinetic Mechanism for a Human Wild-Type GluK2 and a C-terminal Mutant Kainate Receptor
  • Huang, Z., Han, Y., Wang, C.Z., & Niu, L. (2010) Biochemistry 49, 5790-5798. Epub 2010 June 21. Potent and Selective Inhibition of the Open-Channel Conformation of AMPA Receptors by an RNA Aptamer
  • Huang, Z., Pei, W.M., Han, Y., Jayaseelan, S., Shekhtman, A., Shi, H. & Niu, L. (2009) Nucleic Acids Research 37, 4022-4032. Epub 2009 May 5. One RNA aptamer sequence, two structures: a collaborating pair that inhibits AMPA receptors. This article is ranked by Faculty of 1000 as a must-read article
  • Pei, W.M., Huang, Z., Wang, C.Z., Han, Y., Park, J.S. & Niu, L. (2009) Biochemistry 48, 3767-3777. Epub 2009 March 10. Flip and Flop: a Molecular Determinant for AMPA Receptor Channel Opening
  • Huang, Z., Pei, W.M., Han, Y., Jayaseelan, S., Shekhtman, A., Shi, H. & Niu, L. (2009) Nucleic Acids Research, in press. One RNA aptamer sequence, two structures: a collaborating pair that inhibits AMPA receptors
  • Ritz, M., Micale, N., Li, G., Grasso, S. & Niu, L. (2008) Biochemistry 47, 1061-1069. Epub 2007 Dec 28. A Laser-Pulse Photolysis Study of the Mechanism of Inhibition of the GluR2 AMPA Receptor by 2,3-Benzodiazepine Derivatives
  • Huang, Z., Pei, W.M., Shi, H. & Niu, L. (2007) Biochemistry 46, 12648-12655. Epub 2007 Oct 12. RNA aptamers selected against the GluR2 AMPA receptor expressed in HEK-293 cells
  • Pei, W.M., Ritz, M., McCarthy, M., Huang, Z. & Niu, L. (2007) J Biol Chem. 282, 22731-22736. Epub 2007 Jun 1. Receptor occupancy and channel-opening kinetics: a study of GluR1 L497Y AMPA receptor
  • Pei, W.M., Huang, Z., & Niu, L. (2007) Biochemistry 46, 2027-2036. GluR3 Flip and Flop: Differences in Channel-Opening Kinetics
  • Kornreich, B. G., Niu, L., Roberson, M. S. & Oswald, R. E. (2007) Neuroscience 146, 1158-1168. Epub 2007 Mar 26. Identification of C-terminal domain residues involved in protein kinase A-mediated potentiation of GluR6
  • Li, G., Sheng, Z. Y, Huang, Z. & Niu, L. (2005) Biochemistry 44, 5835-41. Kinetic Mechanism of the Channel Opening of GluRDflip AMPA Receptor
  • Huang, Z., Li, G., Pei, W.M., Sosa, L. A. & Niu, L. (2005) J. Neurosci. Methods. 142, 159-166. Enhancing Protein Expression in Single HEK-293 Cells
  • Li, G. & Niu, L. (2004) J. Biol. Chem. 279, 3990-3997. How Fast Does the GluR1Qflip AMPA Receptor Channel Open?
  • Li, G., Oswald, R. E. & Niu, L. (2003) Biochemistry 42, 12367-12375. Channel-Opening Kinetics of the GluR6 Kainate Receptor
  • Li, G., Pei, W. M. & Niu, L. (2003) Biochemistry 42, 12358-12366. Channel-Opening Kinetics of GluR2Qflip AMPA Receptor: A Laser Pulse Photolysis Study
  • Niu L, Kim, J. M. & Khorana, H. G. (2002) Proc. Natl. Acad. Sci. USA 99, 13409-13412. Structure and function in rhodopsin: Asymmetric reconstitution of rhodopsin in liposomes
  • Bruel, C., Cha, K., Niu, L. & Khorana, H. G. (2000) Proc. Natl. Acad. Sci. USA, 97, 3010-3015. Rhodopsin Kinase: Two mAbs Binding Near the Carboxyl Terminus Cause Time-dependent Inactivation
  • Hess, G. P., Ulrich, A. H., Bretinger, H.-G., Niu, L., Armanda, G., Grewer, C., Ippolito, J. E., Lee, S., Jayaraman, V., Srivastava, S. & Coombs, S. E. (2000) Proc. Natl. Acad. Sci. USA 97, 13895-13900. Mechanism-based Discovery of Ligands that Prevent Inhibition of the Nicotinic Acetylchoine Receptor by Cocaine and MK-801
  • Gee, K. R., Niu, L., Schaper, K., Jayaraman, V. & Hess, G. P. (1999) Biochemistry 38, 3140-3147. Synthesis and Photochemistry of a Photolabile Precursor of N-Methyl-D-Aspartate (NMDA) That Is Photolyzed in the Microsecond Time Region and Is Suitable for Chemical Kinetic Investigations of the NMDA receptor
  • Niu, L., Gee, K. R., Schaper, K. & Hess, G. P. (1996) Biochemistry 35, 2030-3036. Synthesis and Photochemical Properties of a Kainate Precursor, and Activation of Kainate and AMPA Receptor-channels on a Microsecond Time Scale
  • Niu, L., Wieboldt, R., Ramesh, D., Carpenter, B. K. & Hess, G. P. (1996) Biochemistry 35, 8136-8142. Synthesis and Characterization of a Caged Receptor Ligand Suitable for Chemical Kinetic Investigations of the Glycine Receptor in the 3 μs Time Domain
  • Niu, L., Vazquez, R. W., Nagel, G., Friedrich, T., Bamberg, E., Oswald, R. E. & Hess, G. P. (1996) Proc. Natl. Acad. Sci. USA, 93, 12964-12968. Rapid Chemical Kinetic Techniques for Investigations of Neurotransmitter Receptors Expressed in Xenopus Oocytes
  • Gee, K. R., Niu, L., Schaper, K., & Hess, G. P. (1995) J. Org. Chemistry 60, 4260-4263. Caged Bioactive Carboxylates. Synthesis, Photolysis Studies, and Biological Characterization of a New Caged N-methyl-D-Aspartate Acid (NMDA)
  • Hess, G. P., Niu, L., & Wieboldt, R. (1995) In Annals New York Acad. Sci. 757, 23-39. Determination of the Chemical Mechanism of Neurotransmitter Receptor-mediated Reactions by Rapid Chemical Kinetic Methods
  • Niu, L., Abood, L. G., & Hess, G. P. (1995) Proc. Natl. Acad. Sci. USA 92, 12008-12012. Cocaine: Mechanism of Inhibition of a Muscle Acetylcholine Receptor Studied by Laser-pulse Photolysis Technique
  • Wieboldt, R., Gee, K. R., Niu, L., Ramesh, D., Carpenter, B. K., & Hess, G. P. (1994) Proc. Natl. Acad. Sci. USA 91, 8752-8756. Photolabile Precursors of Glutamate: Synthesis, Photochemical Properties and Activation of Glutamate Receptors on a Microsecond Time Scale
  • Ramesh, D., Wieboldt, R., Niu, L., Carpenter, B. K., & Hess, G. P. (1993) Proc. Natl. Acad. Sci. USA 90, 11074-11078. Photolysis of a New Protecting Group for the Carboxyl Function of Neurotransmitters within 3 μs and with Product Quantum Yield of 0.2
  • Niu, L., & Hess, G. P. (1993) Biochemistry 32, 3831-3835. An Acetylcholine Receptor Regulatory Site in BC3H1 cells: Characterization by Laser-pulse Photolysis in the Microsecond-to-millisecond Time Domain
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