Li Niu

Patent

  • Nucleic Acid Ligands Specific for Glutamate Receptors (2006, pending at USPTO     Niu, L., Huang, Z., Shi, H., & Lis, J. T.

Publications

  • Pei, W.M., Huang, Z., Wang, C.Z., Han, Y., Park, J.S. & Niu, L. (2009) Biochemistry 48, 3767-3777. Epub 2009 March 10. Flip and Flop: a Molecular Determinant for AMPA Receptor Channel Opening
  • Huang, Z., Pei, W.M., Han, Y., Jayaseelan, S., Shekhtman, A., Shi, H. & Niu, L. (2009) Nucleic Acids Research, in press. One RNA aptamer sequence, two structures: a collaborating pair that inhibits AMPA receptors
  • Ritz, M., Micale, N., Li, G., Grasso, S. & Niu, L. (2008) Biochemistry 47, 1061-1069. Epub 2007 Dec 28. A Laser-Pulse Photolysis Study of the Mechanism of Inhibition of the GluR2 AMPA Receptor by 2,3-Benzodiazepine Derivatives
  • Huang, Z., Pei, W.M., Shi, H. & Niu, L. (2007) Biochemistry 46, 12648-12655. Epub 2007 Oct 12. RNA aptamers selected against the GluR2 AMPA receptor expressed in HEK-293 cells
  • Pei, W.M., Ritz, M., McCarthy, M., Huang, Z. & Niu, L. (2007) J Biol Chem. 282, 22731-22736. Epub 2007 Jun 1. Receptor occupancy and channel-opening kinetics: a study of GluR1 L497Y AMPA receptor
  • Pei, W.M., Huang, Z., & Niu, L. (2007) Biochemistry 46, 2027-2036. GluR3 Flip and Flop: Differences in Channel-Opening Kinetics
  • Kornreich, B. G., Niu, L., Roberson, M. S. & Oswald, R. E. (2007) Neuroscience 146, 1158-1168. Epub 2007 Mar 26. Identification of C-terminal domain residues involved in protein kinase A-mediated potentiation of GluR6
  • Li, G., Sheng, Z. Y, Huang, Z. & Niu, L. (2005) Biochemistry 44, 5835-41. Kinetic Mechanism of the Channel Opening of GluRDflip AMPA Receptor
  • Huang, Z., Li, G., Pei, W.M., Sosa, L. A. & Niu, L. (2005) J. Neurosci. Methods. 142, 159-166. Enhancing Protein Expression in Single HEK-293 Cells
  • Li, G. & Niu, L. (2004) J. Biol. Chem. 279, 3990-3997. How Fast Does the GluR1Qflip AMPA Receptor Channel Open?
  • Li, G., Oswald, R. E. & Niu, L. (2003) Biochemistry 42, 12367-12375. Channel-Opening Kinetics of the GluR6 Kainate Receptor
  • Li, G., Pei, W. M. & Niu, L. (2003) Biochemistry 42, 12358-12366. Channel-Opening Kinetics of GluR2Qflip AMPA Receptor: A Laser Pulse Photolysis Study
  • Niu L, Kim, J. M. & Khorana, H. G. (2002) Proc. Natl. Acad. Sci. USA 99, 13409-13412. Structure and function in rhodopsin: Asymmetric reconstitution of rhodopsin in liposomes
  • Bruel, C., Cha, K., Niu, L. & Khorana, H. G. (2000) Proc. Natl. Acad. Sci. USA, 97, 3010-3015. Rhodopsin Kinase: Two mAbs Binding Near the Carboxyl Terminus Cause Time-dependent Inactivation
  • Hess, G. P., Ulrich, A. H., Bretinger, H.-G., Niu, L., Armanda, G., Grewer, C., Ippolito, J. E., Lee, S., Jayaraman, V., Srivastava, S. & Coombs, S. E. (2000) Proc. Natl. Acad. Sci. USA 97, 13895-13900. Mechanism-based Discovery of Ligands that Prevent Inhibition of the Nicotinic Acetylchoine Receptor by Cocaine and MK-801
  • Gee, K. R., Niu, L., Schaper, K., Jayaraman, V. & Hess, G. P. (1999) Biochemistry 38, 3140-3147. Synthesis and Photochemistry of a Photolabile Precursor of N-Methyl-D-Aspartate (NMDA) That Is Photolyzed in the Microsecond Time Region and Is Suitable for Chemical Kinetic Investigations of the NMDA receptor
  • Niu, L., Gee, K. R., Schaper, K. & Hess, G. P. (1996) Biochemistry 35, 2030-3036. Synthesis and Photochemical Properties of a Kainate Precursor, and Activation of Kainate and AMPA Receptor-channels on a Microsecond Time Scale
  • Niu, L., Wieboldt, R., Ramesh, D., Carpenter, B. K. & Hess, G. P. (1996) Biochemistry 35, 8136-8142. Synthesis and Characterization of a Caged Receptor Ligand Suitable for Chemical Kinetic Investigations of the Glycine Receptor in the 3 μs Time Domain
  • Niu, L., Vazquez, R. W., Nagel, G., Friedrich, T., Bamberg, E., Oswald, R. E. & Hess, G. P. (1996) Proc. Natl. Acad. Sci. USA, 93, 12964-12968. Rapid Chemical Kinetic Techniques for Investigations of Neurotransmitter Receptors Expressed in Xenopus Oocytes
  • Gee, K. R., Niu, L., Schaper, K., & Hess, G. P. (1995) J. Org. Chemistry 60, 4260-4263. Caged Bioactive Carboxylates. Synthesis, Photolysis Studies, and Biological Characterization of a New Caged N-methyl-D-Aspartate Acid (NMDA)
  • Hess, G. P., Niu, L., & Wieboldt, R. (1995) In Annals New York Acad. Sci. 757, 23-39. Determination of the Chemical Mechanism of Neurotransmitter Receptor-mediated Reactions by Rapid Chemical Kinetic Methods
  • Niu, L., Abood, L. G., & Hess, G. P. (1995) Proc. Natl. Acad. Sci. USA 92, 12008-12012. Cocaine: Mechanism of Inhibition of a Muscle Acetylcholine Receptor Studied by Laser-pulse Photolysis Technique
  • Wieboldt, R., Gee, K. R., Niu, L., Ramesh, D., Carpenter, B. K., & Hess, G. P. (1994) Proc. Natl. Acad. Sci. USA 91, 8752-8756. Photolabile Precursors of Glutamate: Synthesis, Photochemical Properties and Activation of Glutamate Receptors on a Microsecond Time Scale
  • Ramesh, D., Wieboldt, R., Niu, L., Carpenter, B. K., & Hess, G. P. (1993) Proc. Natl. Acad. Sci. USA 90, 11074-11078. Photolysis of a New Protecting Group for the Carboxyl Function of Neurotransmitters within 3 μs and with Product Quantum Yield of 0.2
  • Niu, L., & Hess, G. P. (1993) Biochemistry 32, 3831-3835. An Acetylcholine Receptor Regulatory Site in BC3H1 cells: Characterization by Laser-pulse Photolysis in the Microsecond-to-millisecond Time Domain