Chemistry Faculty


Jayanti Pande

Ph.D., University at Albany, SUNY, 1980

LS 2093
Phone: (518) 591-8842
Fax: (518) 442-3462
Email: jpande@albany.edu

Research Interests

Recent Publications

Campus News Stories

Teaching/Training Highlights

 

 

Research Interests:

Our goal is to determine the molecular mechanisms by which genetic mutations and aging alter the proteins in the human eye and lead to eye diseases such as cataract, glaucoma and macular degeneration. Using a number of biophysical and biochemical methods we investigate how soluble proteins and other molecules form insoluble materials that impede normal function and lead to pathology. We expect our findings to lead to the development of novel therapeutic strategies. 

 

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Recent Publications (2011-2008): The following 10 papers highlight our recent findings:

For a complete listing of publications, see here

1.  Banerjee, P. R., Puttamadappa, S. S., Pande, A., Shekhtman, A. and Pande, J. (2011) Increased Hydrophobicity and Decreased Backbone Flexibility Explain the Lower Solubility of a Cataract-Linked Mutant of γD-Crystallin.  J. Mol. Biol. 412,647-659. (http://www.sciencedirect.com/science/article/pii/S0022283611008369)

 

2. Ghosh KS, Pande A, Pande J. (2011) Binding of γ-crystallin substrate prevents the binding of copper and zinc ions to the molecular chaperone α-crystallin. Biochemistry. 50, 3279-81. (http://pubs.acs.org/doi/abs/10.1021/bi200091q)

3. Banerjee, P. R., Pande, A., Patrosz, J., Thurston, G. and Pande, J. (2010) Cataract-associated mutant E107A of human gammaD-crystallin shows increased attraction to alpha-crystallin and enhanced light scattering. Proc. Natl. Acad. Sci. U.S.A., 50, 3279-3281.(Cover article, Epub. December 20, 2010),

(http://www.pnas.org/content/108/2/574.long)

 

For commentaries that provide a broader perspective of this work, see the following:

  • Commentary on the PNAS article: Asherie, N. (2010) Proc. Natl. Acad. Sci. (Early Edition), Dec. 28, doi/10.1073/pnas.1017543108. 

(http://www.pnas.org/content/108/2/437.full)

  • Science and Technology article: Borman, S. (2011) Chemical & Engineering News, 89 (3), Jan. 17, 36.

(http://pubs.acs.org/cen/email/html/8903sci2.html)

4. Pande A, Ghosh KS, Banerjee PR, Pande J. (2010)Increase in surface hydrophobicity of the cataract-associated P23T mutant of human gammaD-crystallin is responsible for its dramatically lower, retrograde solubility. Biochemistry, 49, 6122-9. (http://pubs.acs.org/doi/abs/10.1021/bi100664s) 

5. Danysh BP, Patel TP, Czymmek KJ, Edwards DA, Wang L, Pande J, Duncan MK.(2010) Characterizing molecular diffusion in the lens capsule. Matrix Biol., 29, 228-36. (http://www.ncbi.nlm.nih.gov/pubmed/20026402)

6. Xie,L., Chou, S.-G., Pande, A., Pande, J., Zhang, J.,  Dresselhaus, M. S., Kong, J. and Liu, Z. (2010) Single-Walled Carbon Nanotubes Probing the Denaturation of Lysozyme.  J. Phys. Chem. C, 114,7717–7720.  

7. Pande A, Gillot D, Pande J. (2009) The cataract-associated R14C mutant of human gamma  D-crystallin shows a variety of intermolecular disulfide cross-links: a Raman  spectroscopic study. Biochemistry, 48, 4937-45. (http://pubs.acs.org/doi/abs/10.1021/bi9004182)

8. Pande A, Zhang J, Banerjee PR, Puttamadappa SS, Shekhtman A, Pande J. (2009) NMR study of the cataract-linked P23T mutant of human gammaD-crystallin shows minor changes in hydrophobic patches that reflect its retrograde solubility. Biochem Biophys Res Commun. 382, 196-9. 

9. Wu,Y., Fishkin, N. E., Pande, A., Pande, J. and Sparrow, J. R. (2009)Novel Lipofuscin Bisretinoids Prominent in Human Retina and in a Model of Recessive Stargardt Disease, J. Biol. Chem. 284, 20155-20166.

10. McManus, J., Lomakin, A., Ogun, O., Pande, A., Basan, M., Pande, J. and Benedek,G. B. (2007) "Altered Phase Diagram Due to a Single Point Mutation in Human Gamma-D Crystallin", Proc Natl. Acad. Sci., U.S.A., 104, 16856-61, (Referenced on the cover, Epub. Oct 8, 2007).

 

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Campus News Stories:

UAlbany Chemist Eyes the Role of Proteins Behind Cataracts.             June 21, 2010  (http://www.albany.edu/news/campus_news_9719.php)

Scholarly Success: Going for the Goldwater                                              May 27, 2008
(http://www.albany.edu/news/feature_2615.shtml)

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Teaching/Training Highlights:

University at Albany sophomore Julita Ewa Patrosz won the prestigious Barry M. Goldwater Scholarship in 2008. The scholarship is the nation's premier undergraduate award for outstanding students in the fields of science, engineering and mathematics.

http://www.albany.edu/cas/student_julita_patrosz.shtml

Above: Julita Patrosz and faculty mentor, Jayanti Pande, in the Life Sciences Research Building courtyard.

Julita was a Biochemistry and Molecular Biology major and worked in the lab of her adviser, Associate Professor of Chemistry Dr. Jayanti Pande, engaged in researching the use of biophysical techniques to understand mutations in lens proteins leading to the formation of cataracts. Julita‘s research was included in the well-received PNAS article described above.

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