Publications: H. Chen

  • Barcia G, Fleming MR, Deligniere A, Gazula VR, Brown MR, Langouet M, Chen H, Kronengold J,  Abhyankar A, Cilio R, Nitschke P, Kaminska A, Boddaert N, Casanova JL, Desguerre I, Munnich A, Dulac O, Kaczmarek LK, Colleaux L, Nabbout R (2012). De novo gain-of-function KCNT1 channel mutations cause malignant migrating partial seizures of infancy. Nature genetics. 2012;44(11):1255-9.
  • Ma L, Zhang X, Zhou M, Chen H (2012) Acid-sensitive TWIK and TASK potassium channels change ion selectivity and become permeable to sodium in extracellular acidification. Journal of Biological Chemistry 287: 37145-37153.
  • Ma L, Xie Y, Zhou M,Chen H (2012) Silent TWIK-1 potassium channels conduct monovalent cation currents. Biophysical Journal 102:L34-L36.
  • Ma, L., Zhang, X. and Chen, H. (2011) TWIK-1 Two-Pore Domain Potassium Channels Change Ion Selectivity and Conduct Inward Leak Sodium Currents in Hypokalemia. Science Signaling, 4(176), ra37. [abstract] [full text] [pdf reprint][featured in]
  • Gazula VR, Strumbos JG, Mei X, Chen H, Rahner C, Kaczmarek LK (2010). Localization of Kv1.3 channels in presynaptic terminals of brainstem auditory neurons. Journal of Comparative Neurology. 518(16):3205-20.
  • Zhou, M., Xu,G., Xie, M, Zhang, X., Schools, G.P., Ma, L., Kimelberg, H.K., and Chen, H. (2009) TWIK-1 and TREK-1 are potassium channels contributing significantly to astrocyte passive conductance in rat hippocampal slices. Journal of Neuroscience 29(26): 8551-8564
  • Chen, H., Kronengold, J., Yan, J., Gazula, V.R., Ferreira, G., Yang, Y., Bhattacharjee, A., Sigworth, F.J., Salkoff, L., and Kaczmarek, L.K. (2009) The N-terminal domain of Slack determines the formation and functional expression of Slick/Slack heteromeric sodium-activated potassium channels. Journal of Neuroscience. 29(17): 5654-5665
  • Chen H. and Goldstein S. A. (2007) Serial perturbation of MinK in IKs implies an α-helical transmembrane span traversing the channel corpus. Biophysical Journal, 93(7): 2332-40.
  • Chen H., C. von Hehn, L.K. Kaczmarek, L. R. Ment, B.R. Pober, and F.M. Hisama. (2007) Functional Analysis of a Novel Potassium Channel (KCNA1) Mutation in Hereditary Myokymia. Neurogenetics 8(2):131-5.
  • Sun, A.-Q., Balasubramaniyan N., Chen H., M. Shahid M., Suchy FJ. (2006). Identification of functionally relevant residues of the rat ileal apical sodium dependent bile acid cotransporter (rASBT). Journal of Biological Chemistry 281, 16410-8.
  • Barbier, J., Lamthanh, H., Le Gall F., Favreau P., Benoit E., Chen, H., Gilles N., Ilan N., Heinemann, S.H., Gurevitz M., Gordon D., Ménez A., and Molgó, J. (2004). A δ-conotoxin from Conus ermineus venom inhibits inactivation in vertebrate neuronal Na+ channels, but not in skeletal and cardiac muscles. Journal of Biological Chemistry 279, 4680-4685.
  • Chen H. Kim, L.A., Rajan S., Xu S., and Goldstein, S. A. (2003). Charybdotoxin binding in the IKs pore demonstrates two MinK subunits in each channel complex. Neuron 40, 15-23.
  • Chen, H., Sesti, F., and Goldstein, S. A. (2003). Pore- and State-Dependent Cadmium Block of IKs Channels Formed with MinK-55C and Wild-Type KCNQ1 Subunits. Biophysical Journal 84, 3679-3689.
  • Chen, H., Lu, S., Leipold, E., Gordon, D., Hansel, A., and Heinemann, S. H. (2002). Differential sensitivity of sodium channels from the central and peripheral nervous system to the scorpion toxins Lqh-2 and Lqh-3. European Journal of Neuroscience 16, 767-770.
  • Chen, H., and Heinemann, S. H. (2001). Interaction of scorpion alpha-toxins with cardiac sodium channels: binding properties and enhancement of slow inactivation. Journal of General Physiology 117, 505-518.
  • Gilles, N., Leipold, E., Chen, H., Heinemann, S. H., and Gordon, D. (2001). Effect of depolarization on binding kinetics of scorpion alpha-toxin highlights conformational changes of rat brain sodium channels. Biochemistry 40, 14576-14584.
  • Chen, H., Gordon, D., and Heinemann, S. H. (2000). Modulation of cloned skeletal muscle sodium channels by the scorpion toxins Lqh II, Lqh III, and Lqh alphaIT. Pflugers Arch: European Journal of Physiology 439, 423-432.
  • Gilles, N., Chen, H., Wilson, H., Le Gall, F., Montoya, G., Molgo, J., Schonherr, R., Nicholson, G., Heinemann, S. H., and Gordon, D. (2000). Scorpion alpha and alpha-like toxins differentially interact with sodium channels in mammalian CNS and periphery. European Journal of Neuroscience 12, 2823-2832.
  • Chen, H., Kubo, Y., Hoshi, T., and Heinemann, S.H. (1998). Cyclosporin A selectively reduces functional expression of Kir2.1 potassium channels in Xenopus oocytes. FEBS letters 422, 307-310.