Publications
 

Publications

Intron and Intein Endonucleases

DNA

Belfort M, Bonocora RP.  Homing endonucleases: from genetic anomalies to programmable genomic clippers.  Methods Mol Biol. 2014;1123:1-26.

Bonocora RP, Belfort M.  Mapping homing endonuclease cleavage sites using in vitro generated protein.  Methods Mol Biol. 2014;1123:55-67.   

Robbins, J.B., Smith, D and Belfort, M. Redox-responsive zinc-finger is fidelity switch in homing endonuclease, promoting intron promiscuity under oxidative stress. Current Biol. (2011) 21, 243-248.   

Edgell, D.R., Gibb, E.A., Shub, D.A. and Belfort, M. Mobile DNA elements in T4 and related phages. BMC Virology J. (2010) 7, 290-305.  

Liu, Q.Q., Dansereau, J.T., Puttamadappa, S,S, Shekhtman, A., Derbyshire, V. and Belfort, M. Role of the interdomain linker in distance determination for remote cleavage by homing endonuclease I-TevI . J. Mol. Biol. (2008) 379, 1094-1106.  

Robbins, J.B., Stapleton, M., Stanger, M.J., Smith, D., Dansereau, J.T., Derbyshire, V., and Belfort, M. Homing endonuclease I-TevIII: dimerization as a means to a double-strand break. Nucleic Acids Res. (2007) 35, 1589-1600.  

Liu, Q.Q., Derbyshire, V., Belfort, M. and Edgell, D.R. Distance determination by GIY-YIG intron endonucleases: Discrimination between repression and cleavage functions. Nucleic Acids Res. (2006) 34, 1755-1764.  

Silva, G.H., Belfort, M., Wende, W. and Pingoud, A. From Monomeric to Homodimeric Endonucleases and Back: Engineering Novel Specificity of LAGLIDADG Enzymes. J. Mol. Biol. (2006) 361, 744-754.  

Van Roey, P., Belfort, M., Derbyshire, V. Homing endonuclease I-TevI: an atypical zinc finger with a novel function. In: Iuchi S, Kuldell N, eds. Zinc finger proteins: from atomic contact to cellular function. Georgetown: Landes Bioscience, New York: Kluwer Academic / Plenum Publishers (2005) 35-38.  

Belfort, M. Back to basics: structure, function, evolution and application of homing endonucleases and inteins, in Homing Endonucleases and Inteins, Eds. Belfort, M., Derbyshire, V., Stoddard, B.L. and Wood, D.W., Springer-Verlag (2005) pp. 1-10.  

Silva, G.H. and Belfort, M. Analysis of the LAGLIDADG interface of the monomeric homing endonuclease I-DmoI. Nucleic Acids Res. (2004) 32, 3156-3168.  

NGEC

Edgell, D.R., Derbyshire, V., Van Roey, P., LaBonne, S., Stanger, M.J., Li, Z., Boyd, T.M., Shub, D.A., and Belfort, M. Intron-encoded homing endonuclease I-TevI also functions as a transcriptional autorepressor. Nat. Struct. Mol. Biol. (2004) 11, 936-944. 

Edgell, D.R., Stanger, M.J., and Belfort, M. Coincidence of cleavage sites of intron endonuclease I-TevI and critical sequences of the host thymidylate synthase gene. J. Mol. Biol. (2004) 343, 1231-1241.  

Roberts, R.J., Belfort, M. et al. A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes. Nucleic Acids Res. (2003) 31, 1805-1812.  

Edgell, D.R., Stanger, M.J. and M. Belfort. Importance of a single base pair for discrimination between intron-containing and intronless alleles by endonuclease I-BmoI. Curr. Biol. (2003) 13, 973-978.  

Liu, Q., Belle, A., Shub, D.A., Belfort, M. and Edgell, D.R. SegG endonuclease promotes marker exclusion and mediates co-conversion from a distant cleavage site. J. Mol. Biol. (2003) 334, 13-23. 

Belfort, M. Two for the price of one: a bifunctional intron-encoded DNA endonuclease-RNA maturase. Genes Dev. (2003) 17, 2860-2863.


Reviews

Belfort, M. and Lambowitz, A. Mobile bacterial group II introns at the crux of eurkaryotic evolution. Microbiol Spectr. (2015) 3, 1209-1236.

Novikova O, Topilina N, Marlene B.  Enigmatic distribution, evolution and function of inteins.  J Biol Chem. 2014;289 (21).

Belfort M, Bonocora RP.  Homing endonucleases: from genetic anomalies to programmable genomic clippers.  Methods Mol Biol. 2014;1123:1-26.   

Edgell, D.R., Chalamcharla, V.R. and Belfort, M. Learning to live together: mutualism between self-splicing introns and host genomes. BMC Biology (2011) 9, 22.   

Belfort, M., Curcio, M.J., and Lue, N.F. Telomerase and retrotransposons: Reverse transcriptases that shaped genomes. Proc. Natl. Acad. Sci. USA (2011) 108, 20304-20310.  

Stoddard, B. and Belfort, M. Social networking between mobile introns and their host genes. Mol. Micro. (2010) 78, 1-4.  

Edgell, D.R., Gibb, E.A. and Belfort, M. Mobile DNA elements in T-even phage. BMC Virology J. (2010) 7, 290-305.  

Belfort, M. Scientific serendipity initiates an intron odyssey. J. Biol. Chem. (2009) 284, 29997-30003.  

Beauregard, A., Curcio, M.J. and Belfort, M. The take and give between retrotransposable elements and their hosts. Annu. Rev. Genetics. (2008) 42, 587-617.  

Van Roey, P., Belfort, M., Derbyshire, V. Homing endonuclease I-TevI: an atypical zinc finger with a novel function. In: Iuchi S, Kuldell N, eds. Zinc finger proteins: from atomic contact to cellular function. Georgetown: Landes Bioscience, New York: Kluwer Academic / Plenum Publishers (2005) 35-38.  

Belfort, M. Back to basics: structure, function, evolution and application of homing endonucleases and inteins, in Homing Endonucleases and Inteins, Eds. Belfort, M., Derbyshire, V., Stoddard, B.L. and Wood, D.W., Springer-Verlag (2005) pp. 1-10.  

Roberts, R.J., Belfort, M. et al. A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes. Nucleic Acids Res. (2003) 31, 1805-1812.  

Belfort, M. Two for the price of one: a bifunctional intron-encoded DNA endonuclease-RNA maturase. Genes Dev. (2003) 17, 2860-2863.